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UniProtKB/Swiss-Prot entry P14543


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NID1_HUMAN
Primary accession number P14543
Secondary accession numbers Q14942 Q59FL2 Q5TAF2 Q5TAF3 Q86XD7
Integrated into Swiss-Prot on January 1, 1990
Sequence was last modified on February 7, 2006 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 105)
Name and origin of the protein
Protein name Nidogen-1 [Precursor]
Synonym Entactin
Gene name
Name: NID1
Synonyms: NID
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=2574658 [NCBI, ExPASy, EBI, Israel, Japan]
Nagayoshi T., Sanborn D., Hickok N.J., Olsen D.R., Fazio M.J., Chu M.-L., Knowlton R., Mann K., Deutzmann R., Timpl R., Uitto J.;
"Human nidogen: complete amino acid sequence and structural domains deduced from cDNAs, and evidence for polymorphism of the gene.";
DNA 8:581-594(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.1995.1038; PubMed=7557988 [NCBI, ExPASy, EBI, Israel, Japan]
Zimmermann K., Hoischen S., Hafner M., Nischt R.;
"Genomic sequences and structural organization of the human nidogen gene (NID).";
Genomics 27:245-250(1995).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
DOI=10.1111/1523-1747.ep12480380; PubMed=1906509 [NCBI, ExPASy, EBI, Israel, Japan]
Fazio M.J., O'Leary J., Kahari V.M., Chen Y.Q., Saitta B., Uitto J.;
"Human nidogen gene: structural and functional characterization of the 5'-flanking region.";
J. Invest. Dermatol. 97:281-285(1991).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1247 (ISOFORM 2).
TISSUE=Brain;
Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno F.R.;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 667-1247 (ISOFORM 1).
TISSUE=Placenta;
PubMed=2471408 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen D.R., Nagayoshi T., Fazio M., Mattei M.-G., Passage E., Weil D., Timpl R., Chu M.-L., Uitto J.;
"Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome 1q43.";
Am. J. Hum. Genet. 44:876-885(1989).
[8]
VARIANT [LARGE SCALE ANALYSIS] SER-1036.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M30269; AAA59932.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X82245; CAA57709.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84819; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84820; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84821; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84822; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84823; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84824; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84825; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84826; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84827; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84828; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84829; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84830; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84831; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84832; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84833; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84834; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84835; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84836; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X84837; CAA57709.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL122018; CAI22680.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL139161; CAI22680.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL122018; CAI22681.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL139161; CAI22681.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL139161; CAI23421.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL122018; CAI23421.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL139161; CAI23422.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL122018; CAI23422.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC045606; AAH45606.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB209448; BAD92685.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M27445; AAA57261.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A33322; MMHUND.
RefSeq NP_002499.2; -.
UniGene Hs.356624
3D structure databases
PDB
1NDX; Model; -; A=941-1206.[ExPASy / RCSB / EBI]
PDBsum 1NDX; -.
SMR P14543; 389-661.
ModBase P14543.
Organism-specific databases
HGNC HGNC:7821; NID1.
GenAtlas NID1.
HPA CAB010044; -.
MIM 131390; gene. [NCBI / EBI]
PharmGKB PA31625; -.
GeneCards P14543.
Gene expression databases
ArrayExpress P14543; -.
CleanEx HS_NID1; -.
GermOnline ENSG00000116962; Homo sapiens.
Family and domain databases
InterPro IPR011042; 6-blade_b-propeller_TolB-like.
IPR006210; EGF.
IPR000152; EGF-type_Asp/Asn_hydroxyl_CS.
IPR000742; EGF_3.
IPR001881; EGF_Ca_bd.
IPR013091; EGF_Ca_bd_2.
IPR006209; EGF_like.
IPR013032; EGF_like_reg_CS.
IPR006605; G2F.
IPR000033; LDLR.
IPR003886; NIDO.
IPR000716; Thyroglobulin_1.
Graphical view of domain structure.
Gene3D G3DSA:2.120.10.30; 6-blade_b-propeller_TolB-like; 1.
G3DSA:4.10.800.10; Thyroglobulin_1; 1.
Pfam PF00008; EGF; 2.
PF07645; EGF_CA; 2.
PF07474; G2F; 1.
PF00058; Ldl_recept_b; 3.
PF06119; NIDO; 1.
PF00086; Thyroglobulin_1; 1.
Pfam graphical view of domain structure.
SMART SM00181; EGF; 4.
SM00179; EGF_CA; 2.
SM00682; G2F; 1.
SM00135; LY; 5.
SM00539; NIDO; 1.
SM00211; TY; 1.
SMART graphical view of domain structure.
PROSITE PS00010; ASX_HYDROXYL; 3.
PS00022; EGF_1; 1.
PS01186; EGF_2; 5.
PS50026; EGF_3; 5.
PS01187; EGF_CA; 2.
PS51120; LDLRB; 4.
PS51220; NIDO; 1.
PS50993; NIDOGEN_G2; 1.
PS00484; THYROGLOBULIN_1_1; 1.
PS51162; THYROGLOBULIN_1_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P14543.
Genome annotation databases
Ensembl ENSG00000116962; Homo sapiens. [Contig view]
GeneID 4811; -.
KEGG hsa:4811; -.
Phylogenomic databases
HOGENOM P14543; -.
HOVERGEN P14543; -.
Other
DrugBank DB00102; Becaplermin.
DB00013; Urokinase.
SOURCE NID1; Homo sapiens.
ProtoNet P14543.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; Basement membrane; Calcium; Cell adhesion; EGF-like domain; Extracellular matrix; Glycoprotein; Polymorphism; Repeat; Secreted; Signal; Sulfation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     28  28      
CHAIN   29   1247  1219     Nidogen-1. PRO_0000007669
DOMAIN   106    268  163     NIDO. 
DOMAIN   386    426  41     EGF-like 1. 
DOMAIN   430    667  238     Nidogen G2 beta-barrel. 
DOMAIN   668    709  42     EGF-like 2. 
DOMAIN   710    751  42     EGF-like 3; calcium-binding (Potential). 
DOMAIN   758    801  44     EGF-like 4. 
DOMAIN   802    840  39     EGF-like 5; calcium-binding (Potential). 
DOMAIN   846    919  74     Thyroglobulin type-1. 
REPEAT   990   1032  43     LDL-receptor class B 1. 
REPEAT   1033   1075  43     LDL-receptor class B 2. 
REPEAT   1076   1120  45     LDL-receptor class B 3. 
REPEAT   1121   1162  42     LDL-receptor class B 4. 
DOMAIN   1208   1244  37     EGF-like 6. 
MOTIF   702    704  3     Cell attachment site. 
MOD_RES   289    289        Sulfotyrosine (Potential). 
MOD_RES   296    296        Sulfotyrosine (Potential). 
CARBOHYD   1137   1137        N-linked (GlcNAc...) (Potential). 
DISULFID   390    403        By similarity. 
DISULFID   397    412        By similarity. 
DISULFID   411    618        By similarity. 
DISULFID   414    425        By similarity. 
DISULFID   672    685        By similarity. 
DISULFID   679    695        By similarity. 
DISULFID   697    708        By similarity. 
DISULFID   714    727        By similarity. 
DISULFID   721    736        By similarity. 
DISULFID   738    750        By similarity. 
DISULFID   762    777        By similarity. 
DISULFID   769    787        By similarity. 
DISULFID   789    800        By similarity. 
DISULFID   806    817        By similarity. 
DISULFID   811    826        By similarity. 
DISULFID   828    839        By similarity. 
DISULFID   849    878        By similarity. 
DISULFID   889    896        By similarity. 
DISULFID   898    919        By similarity. 
DISULFID   1212   1223        By similarity. 
DISULFID   1219   1232        By similarity. 
DISULFID   1234   1243        By similarity. 
VAR_SEQ   710    842        Missing (in isoform 2). VSP_017254
VARIANT   246    246  1     I -> V (in dbSNP:rs10733133 [NCBI]). VAR_024264 
VARIANT   669    669  1     Q -> R (in dbSNP:rs3738534 [NCBI]). VAR_021904 
VARIANT   1036   1036  1     F -> S (in a colorectal cancer sample; somatic mutation). VAR_035835 
CONFLICT   33     34        EL -> SS (in Ref. 2; CAA57709). 
CONFLICT   37     42        FGPGQG -> SAPDR (in Ref. 2; CAA57709). 
CONFLICT   60     60        S -> R (in Ref. 4; AAH45606). 
CONFLICT   653    653        F -> L (in Ref. 3, 4; AAH45606 and 6). 
CONFLICT   807    807        Q -> H (in Ref. 6; BAD92685). 
CONFLICT   1115   1115        T -> H (in Ref. 1 and 2). 
CONFLICT   1246   1246        R -> Q (in Ref. 3, 4; AAH45606 and 6). 
STRAND   945    950  6      
STRAND   953    958  6      
STRAND   971    974  4      
STRAND   978    985  8      
STRAND   989    996  8      
STRAND   1001   1009  9      
STRAND   1012   1017  6      
STRAND   1023   1030  8      
TURN   1031   1033  3      
STRAND   1034   1039  6      
TURN   1040   1042  3      
STRAND   1045   1049  5      
TURN   1050   1053  4      
STRAND   1054   1058  5      
STRAND   1066   1071  6      
STRAND   1075   1082  8      
STRAND   1089   1094