ID CMPA_BACSU Reviewed; 214 AA. AC P14204; DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1990, sequence version 1. DT 10-JUN-2008, entry version 75. DE Competence protein A. GN Name=comA; Synonyms=comA1, comAA; OrderedLocusNames=BSU31680; OS Bacillus subtilis. OC Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus. OX NCBI_TaxID=1423; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=90008771; PubMed=2507523; RA Weinrauch Y., Guillen N., Dubnau D.; RT "Sequence and transcription mapping of Bacillus subtilis competence RT genes comB and comA, one of which is related to a family of bacterial RT regulatory determinants."; RL J. Bacteriol. 171:5362-5375(1989). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=168; RX MEDLINE=97419515; PubMed=9274030; RA Oudega B., Koningstein G., Rodrigues L., de Sales Ramon M., RA Hilbert H., Duesterhoeft A., Pohl T.M., Weitzenegger T.; RT "Analysis of the Bacillus subtilis genome: cloning and nucleotide RT sequence of a 62 kb region between 275 degrees (rrnB) and 284 degrees RT (pai)."; RL Microbiology 143:2769-2774(1997). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=168; RX MEDLINE=98044033; PubMed=9384377; DOI=10.1038/36786; RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., RA Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., RA Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., RA Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M., RA Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., RA Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., RA Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., RA Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., RA Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., RA Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., RA Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., RA Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., RA Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., RA Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., RA Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., RA Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., RA Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., RA Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., RA Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., RA Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., RA Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., RA Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., RA Yoshikawa H., Danchin A.; RT "The complete genome sequence of the Gram-positive bacterium Bacillus RT subtilis."; RL Nature 390:249-256(1997). RN [4] RP FUNCTION. RX PubMed=16091051; DOI=10.1111/j.1365-2958.2005.04749.x; RA Comella N., Grossman A.D.; RT "Conservation of genes and processes controlled by the quorum response RT in bacteria: characterization of genes controlled by the quorum- RT sensing transcription factor ComA in Bacillus subtilis."; RL Mol. Microbiol. 57:1159-1174(2005). CC -!- FUNCTION: Response regulator in the two-component regulatory CC system comP/comA involved in a major quorum response pathway that CC regulates the development of genetic competence. Regulates CC directly the expression of over 20 genes, including genes of the CC srfA operon, degQ, rapA, rapC, rapE, rapF, etc. Regulates CC indirectly, through the regulation of comK transcription, the CC expression of late competence genes. CC -!- PTM: Phosphorylated by comP. CC -!- SIMILARITY: Contains 1 HTH luxR-type DNA-binding domain. CC -!- SIMILARITY: Contains 1 response regulatory domain. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M22856; AAA22320.1; -; Genomic_DNA. DR EMBL; Z93932; CAB07904.1; -; Genomic_DNA. DR EMBL; Z99120; CAB15156.1; -; Genomic_DNA. DR PIR; A33591; RGBSCA. DR RefSeq; NP_391046.1; -. DR GeneID; 937179; -. DR GenomeReviews; AL009126_GR; BSU31680. DR KEGG; bsu:BSU31680; -. DR SubtiList; BG10381; comA. DR HOGENOM; P14204; -. DR BioCyc; BSUB224308:BSU3163-MON; -. DR InterPro; IPR000792; HTH_LuxR. DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver. DR InterPro; IPR011991; Wing_hlx_DNA_bd. DR Gene3D; G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1. DR Pfam; PF00196; GerE; 1. DR Pfam; PF00072; Response_reg; 1. DR PRINTS; PR00038; HTHLUXR. DR ProDom; PD000307; HTH_LuxR; 1. DR ProDom; PD000039; Response_reg; 1. DR SMART; SM00421; HTH_LUXR; 1. DR SMART; SM00448; REC; 1. DR PROSITE; PS00622; HTH_LUXR_1; 1. DR PROSITE; PS50043; HTH_LUXR_2; 1. DR PROSITE; PS50110; RESPONSE_REGULATORY; 1. PE 3: Inferred from homology; KW Activator; Competence; Complete proteome; DNA-binding; Phosphoprotein; KW Transcription; Transcription regulation; KW Two-component regulatory system. FT CHAIN 1 214 Competence protein A. FT /FTId=PRO_0000081075. FT DOMAIN 1 121 Response regulatory. FT DOMAIN 147 212 HTH luxR-type. FT DNA_BIND 171 190 H-T-H motif (By similarity). FT MOD_RES 55 55 4-aspartylphosphate (By similarity). SQ SEQUENCE 214 AA; 24129 MW; 52D01A9740759072 CRC64; MKKILVIDDH PAVMEGTKTI LETDSNLSVD CLSPEPSEQF IKQHDFSSYD LILMDLNLGG EVNGMELSKQ ILQENPHCKI IVYTGYEVED YFEEAIRAGL HGAISKTESK EKITQYIYHV LNGEILVDFA YFKQLMTQQK TKPAPSSQKE QDVLTPRECL ILQEVEKGFT NQEIADALHL SKRSIEYSLT SIFNKLNVGS RTEAVLIAKS DGVL //