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UniProtKB/Swiss-Prot entry P14056

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ARAF_RAT
Primary accession number P14056
Secondary accession numbers None
Integrated into Swiss-Prot on January 1, 1990
Sequence was last modified on January 1, 1990 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 82)
Name and origin of the protein
Protein name A-Raf proto-oncogene serine/threonine-protein kinase
Synonym EC 2.7.11.1
Gene name
Name: Araf
Synonyms: A-raf, Araf1
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Fischer;
TISSUE=Liver;
PubMed=3449797 [NCBI, ExPASy, EBI, Israel, Japan]
Ishikawa F., Takaku F., Nagao M., Sugimura T.;
"The complete primary structure of the rat A-raf cDNA coding region: conservation of the putative regulatory regions present in rat c-raf.";
Oncogene Res. 1:243-253(1987).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X06942; CAA30023.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S00726; S00726.
RefSeq NP_071977.1; -.
UniGene Rn.1714
3D structure databases
HSSP P04049; 1FAR. [HSSP ENTRY / PDB]
SMR P14056; 20-91, 96-146, 301-574.
ModBase P14056.
PTM databases
PhosphoSite P14056; -.
Organism-specific databases
RGD 2148; Araf.
Gene expression databases
ArrayExpress P14056; -.
GermOnline ENSRNOG00000010838; Rattus norvegicus.
Family and domain databases
InterPro IPR002219; DAG_PE_bd.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR003116; Raf_like_ras_bd.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.
Pfam PF00130; C1_1; 1.
PF00069; Pkinase; 1.
PF02196; RBD; 1.
Pfam graphical view of domain structure.
PRINTS PR00008; DAGPEDOMAIN.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00109; C1; 1.
SM00455; RBD; 1.
SMART graphical view of domain structure.
PROSITE PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P14056.
Genome annotation databases
Ensembl ENSRNOG00000010838; Rattus norvegicus. [Contig view]
GeneID 64363; -.
Phylogenomic databases
HOVERGEN P14056; -.
Other
ProtoNet P14056.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Kinase; Metal-binding; Nucleotide-binding; Phorbol-ester binding; Phosphoprotein; Proto-oncogene; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   604  604     A-Raf proto-oncogene serine/threonine-protein kinase. PRO_0000085625
DOMAIN   19    91  73     RBD. 
DOMAIN   308   568  261     Protein kinase. 
ZN_FING   98   144  47     Phorbol-ester/DAG-type. 
NP_BIND   314   322  9     ATP (By similarity). 
ACT_SITE   427   427        Proton acceptor (By similarity). 
METAL   99    99        Zinc 1 (By similarity). 
METAL   112   112        Zinc 2 (By similarity). 
METAL   115   115        Zinc 2 (By similarity). 
METAL   125   125        Zinc 1 (By similarity). 
METAL   128   128        Zinc 1 (By similarity). 
METAL   133   133        Zinc 2 (By similarity). 
METAL   136   136        Zinc 2 (By similarity). 
METAL   144   144        Zinc 1 (By similarity). 
BINDING   334   334        ATP (By similarity). 
MOD_RES   213   213        Phosphothreonine (By similarity). 
MOD_RES   215   215        Phosphothreonine (By similarity). 
MOD_RES   255   255        Phosphoserine (By similarity). 
MOD_RES   580   580        Phosphoserine (By similarity). 
Sequence information
Length: 604 AA [This is the length of the unprocessed precursor] Molecular weight: 67551 Da [This is the MW of the unprocessed precursor] CRC64: FF24FB2170B0B115 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEPPRGPPAS GAEPSRAVGT VKVYLPNKQR TVVTVRDGMS VYDSLDKALK VRGLNQDCCV 

        70         80         90        100        110        120 
VYRLIKGRKT VTAWDTAIAP LDGEELIVEV LEDVPLTMHN FVRKTFFSLA FCDFCLKFLF 

       130        140        150        160        170        180 
HGFRCQTCGY KFHQHCSSKV PTVCVDMSTN RRQFYHSIQD LSGGSRQQEV PSNLSVNELL 

       190        200        210        220        230        240 
TPQGPSPFTQ QRDQEHFSFP APANPPLQRI RSTSTPNVHM VSTTAPMDSS LMQFTAQSFS 

       250        260        270        280        290        300 
TDAAGRGGDG APRGSPSPAS VSSGRKSPHS KLPAEQRERK SLADEKKKVK NLGYRDSGYY 

       310        320        330        340        350        360 
WEVPPSEVQL LKRIGTGSFG TVFRGRWHGD VAVKVLKVAQ PTAEQAQAFK NEMQVLRKTR 

       370        380        390        400        410        420 
HVNILLFMGF MTRPGFAIIT QWCEGSSLYH HLHVADTRFD MVQLIDVARQ TAQGMDYLHA 

       430        440        450        460        470        480 
KNIIHRDLKS NNIFLHEGLT VKIGDFGLAT VKTRWSGAQP LEQPSGSVLW MAAEVIRMQD 

       490        500        510        520        530        540 
PNPYSFQSDV YAYGVVLYEL MTGSLPYSHI GSRDQIIFMV GRGYLSPDLS KIFSNCPKAM 

       550        560        570        580        590        600 
RRLLTDCLKF QREERPLFPQ ILATIELLQR SLPKIERSAS EPSLHRTQAD ELPACLLSAA 


RLVP
P14056 in FASTA format

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