[1]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
DOI=10.1016/0022-2836(88)90122-2; PubMed=3210246 [NCBI, ExPASy, EBI, Israel, Japan]
Bestor T.H.,
Laudano A.,
Mattaliano R.,
Ingram V.;
"Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases.";
J. Mol. Biol. 203:971-983(1988).
|
[2]
|
SEQUENCE REVISION TO N-TERMINUS.
TISSUE=Embryo;
DOI=10.1074/jbc.271.49.31092; PubMed=8940105 [NCBI, ExPASy, EBI, Israel, Japan]
Yoder J.A.,
Yen R.-W.C.,
Vertino P.M.,
Bestor T.H.,
Baylin S.B.;
"New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase.";
J. Biol. Chem. 271:31092-31097(1996).
|
[3]
|
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
STRAIN=C57BL/6;
TISSUE=Skeletal muscle;
PubMed=11063128 [NCBI, ExPASy, EBI, Israel, Japan]
Aguirre-Arteta A.M.,
Grunewald I.,
Cardoso M.C.,
Leonhardt H.;
"Expression of an alternative Dnmt1 isoform during muscle differentiation.";
Cell Growth Differ. 11:551-559(2000).
|
[4]
|
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
STRAIN=C57BL/6;
DOI=10.1006/jmbi.2000.3588; PubMed=10715201 [NCBI, ExPASy, EBI, Israel, Japan]
Margot J.B.,
Aguirre-Arteta A.M.,
Di Giacco B.V.,
Pradhan S.,
Roberts R.J.,
Cardoso M.C.,
Leonhardt H.;
"Structure and function of the mouse DNA methyltransferase gene: Dnmt1 shows a tripartite structure.";
J. Mol. Biol. 297:293-300(2000).
|
[5]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6;
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
|
[6]
|
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-27 AND 119-1619 (ISOFORMS 1 AND 2).
PubMed=9449671 [NCBI, ExPASy, EBI, Israel, Japan]
Mertineit C.,
Yoder J.A.,
Taketo T.,
Laird D.W.,
Trasler J.M.,
Bestor T.H.;
"Sex-specific exons control DNA methyltransferase in mammalian germ cells.";
Development 125:889-897(1998).
|
[7]
|
NUCLEOTIDE SEQUENCE OF 1-144 (ISOFORMS 1 AND 2), AND PROTEIN SEQUENCE OF 3-6.
STRAIN=129/Sv, and BALB/c;
TISSUE=Embryonic stem cell;
DOI=10.1074/jbc.273.49.32725; PubMed=9830015 [NCBI, ExPASy, EBI, Israel, Japan]
Gaudet F.,
Talbot D.,
Leonhardt H.,
Jaenisch R.;
"A short DNA methyltransferase isoform restores methylation in vivo.";
J. Biol. Chem. 273:32725-32729(1998).
|
[8]
|
NUCLEOTIDE SEQUENCE [MRNA] OF 1-119 (ISOFORM 1).
STRAIN=129/Sv;
TISSUE=Embryonic stem cell, and Kidney;
DOI=10.1073/pnas.93.23.12920; PubMed=8917520 [NCBI, ExPASy, EBI, Israel, Japan]
Tucker K.L.,
Talbot D.,
Lee M.A.,
Leonhardt H.,
Jaenisch R.;
"Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene.";
Proc. Natl. Acad. Sci. U.S.A. 93:12920-12925(1996).
|
[9]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-272 (ISOFORM 1).
STRAIN=C57BL/6J;
TISSUE=Embryo;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P.,
Kasukawa T.,
Katayama S.,
Gough J.,
Frith M.C.,
Maeda N.,
Oyama R.,
Ravasi T.,
Lenhard B.,
Wells C.,
Kodzius R.,
Shimokawa K.,
Bajic V.B.,
Brenner S.E.,
Batalov S.,
Forrest A.R.,
Zavolan M.,
Davis M.J.,
Wilming L.G., ![]()
Aidinis V.,
Allen J.E.,
Ambesi-Impiombato A.,
Apweiler R.,
Aturaliya R.N.,
Bailey T.L.,
Bansal M.,
Baxter L.,
Beisel K.W.,
Bersano T.,
Bono H.,
Chalk A.M.,
Chiu K.P.,
Choudhary V.,
Christoffels A.,
Clutterbuck D.R.,
Crowe M.L.,
Dalla E.,
Dalrymple B.P.,
de Bono B.,
Della Gatta G.,
di Bernardo D.,
Down T.,
Engstrom P.,
Fagiolini M.,
Faulkner G.,
Fletcher C.F.,
Fukushima T.,
Furuno M.,
Futaki S.,
Gariboldi M.,
Georgii-Hemming P.,
Gingeras T.R.,
Gojobori T.,
Green R.E.,
Gustincich S.,
Harbers M.,
Hayashi Y.,
Hensch T.K.,
Hirokawa N.,
Hill D.,
Huminiecki L.,
Iacono M.,
Ikeo K.,
Iwama A.,
Ishikawa T.,
Jakt M.,
Kanapin A.,
Katoh M.,
Kawasawa Y.,
Kelso J.,
Kitamura H.,
Kitano H.,
Kollias G.,
Krishnan S.P.,
Kruger A.,
Kummerfeld S.K.,
Kurochkin I.V.,
Lareau L.F.,
Lazarevic D.,
Lipovich L.,
Liu J.,
Liuni S.,
McWilliam S.,
Madan Babu M.,
Madera M.,
Marchionni L.,
Matsuda H.,
Matsuzawa S.,
Miki H.,
Mignone F.,
Miyake S.,
Morris K.,
Mottagui-Tabar S.,
Mulder N.,
Nakano N.,
Nakauchi H.,
Ng P.,
Nilsson R.,
Nishiguchi S.,
Nishikawa S.,
Nori F.,
Ohara O.,
Okazaki Y.,
Orlando V.,
Pang K.C.,
Pavan W.J.,
Pavesi G.,
Pesole G.,
Petrovsky N.,
Piazza S.,
Reed J.,
Reid J.F.,
Ring B.Z.,
Ringwald M.,
Rost B.,
Ruan Y.,
Salzberg S.L.,
Sandelin A.,
Schneider C.,
Schoenbach C.,
Sekiguchi K.,
Semple C.A.,
Seno S.,
Sessa L.,
Sheng Y.,
Shibata Y.,
Shimada H.,
Shimada K.,
Silva D.,
Sinclair B.,
Sperling S.,
Stupka E.,
Sugiura K.,
Sultana R.,
Takenaka Y.,
Taki K.,
Tammoja K.,
Tan S.L.,
Tang S.,
Taylor M.S.,
Tegner J.,
Teichmann S.A.,
Ueda H.R.,
van Nimwegen E.,
Verardo R.,
Wei C.L.,
Yagi K.,
Yamanishi H.,
Zabarovsky E.,
Zhu S.,
Zimmer A.,
Hide W.,
Bult C.,
Grimmond S.M.,
Teasdale R.D.,
Liu E.T.,
Brusic V.,
Quackenbush J.,
Wahlestedt C.,
Mattick J.S.,
Hume D.A.,
Kai C.,
Sasaki D.,
Tomaru Y.,
Fukuda S.,
Kanamori-Katayama M.,
Suzuki M.,
Aoki J.,
Arakawa T.,
Iida J.,
Imamura K.,
Itoh M.,
Kato T.,
Kawaji H.,
Kawagashira N.,
Kawashima T.,
Kojima M.,
Kondo S.,
Konno H.,
Nakano K.,
Ninomiya N.,
Nishio T.,
Okada M.,
Plessy C.,
Shibata K.,
Shiraki T.,
Suzuki S.,
Tagami M.,
Waki K.,
Watahiki A.,
Okamura-Oho Y.,
Suzuki H.,
Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
|
[10]
|
PROTEIN SEQUENCE OF 1108-1154, AND ENZYME REGULATION.
PubMed=1628623 [NCBI, ExPASy, EBI, Israel, Japan]
Bestor T.H.;
"Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.";
EMBO J. 11:2611-2617(1992).
|
[11]
|
PHOSPHORYLATION AT SER-515, AND MASS SPECTROMETRY.
TISSUE=Erythroleukemia;
DOI=10.1074/jbc.272.28.17851; PubMed=9211941 [NCBI, ExPASy, EBI, Israel, Japan]
Glickman J.F.,
Pavlovich J.G.,
Reich N.O.;
"Peptide mapping of the murine DNA methyltransferase reveals a major phosphorylation site and the start of translation.";
J. Biol. Chem. 272:17851-17857(1997).
|
[12]
|
INTERACTION WITH HDAC1.
DOI=10.1038/71750; PubMed=10615135 [NCBI, ExPASy, EBI, Israel, Japan]
Fuks F.,
Burgers W.A.,
Brehm A.,
Hughes-Davies L.,
Kouzarides T.;
"DNA methyltransferase Dnmt1 associates with histone deacetylase activity.";
Nat. Genet. 24:88-91(2000).
|
[13]
|
INTERACTION WITH HDAC2 AND DMAP1.
DOI=10.1038/77023; PubMed=10888872 [NCBI, ExPASy, EBI, Israel, Japan]
Rountree M.R.,
Bachman K.E.,
Baylin S.B.;
"DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.";
Nat. Genet. 25:269-277(2000).
|
[14]
|
FUNCTION, AND SUBCELLULAR LOCATION.
DOI=10.1016/S0092-8674(01)00280-X; PubMed=11290321 [NCBI, ExPASy, EBI, Israel, Japan]
Howell C.Y.,
Bestor T.H.,
Ding F.,
Latham K.E.,
Mertineit C.,
Trasler J.M.,
Chaillet J.R.;
"Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.";
Cell 104:829-838(2001).
|
[15]
|
ALLOSTERIC REGULATION.
DOI=10.1006/jmbi.2001.4709; PubMed=11399088 [NCBI, ExPASy, EBI, Israel, Japan]
Fatemi M.,
Hermann A.,
Pradhan S.,
Jeltsch A.;
"The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA.";
J. Mol. Biol. 309:1189-1199(2001).
|
[16]
|
INTERACTION WITH THE PRC2 COMPLEX.
DOI=10.1038/nature04431; PubMed=16357870 [NCBI, ExPASy, EBI, Israel, Japan]
Vire E.,
Brenner C.,
Deplus R.,
Blanchon L.,
Fraga M.,
Didelot C.,
Morey L.,
Van Eynde A.,
Bernard D.,
Vanderwinden J.-M.,
Bollen M.,
Esteller M.,
Di Croce L.,
de Launoit Y.,
Fuks F.;
"The Polycomb group protein EZH2 directly controls DNA methylation.";
Nature 439:871-874(2006).
|
[17]
|
ERRATUM.
Vire E.,
Brenner C.,
Deplus R.,
Blanchon L.,
Fraga M.,
Didelot C.,
Morey L.,
Van Eynde A.,
Bernard D.,
Vanderwinden J.-M.,
Bollen M.,
Esteller M.,
Di Croce L.,
de Launoit Y.,
Fuks F.;
Nature 446:824-824(2006).
|
|
ExPASy Home page
