[1]	NUCLEOTIDE SEQUENCE [GENOMIC RNA]. PubMed=3045120 [NCBI, ExPASy, EBI, Israel, Japan] Gorman J.J., Nestorowicz A., Mitchell S.J., Corino G.L., Selleck P.W.; "Characterization of the sites of proteolytic activation of Newcastle disease virus membrane glycoprotein precursors."; J. Biol. Chem. 263:12522-12531(1988).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC RNA]. DOI=10.1016/0042-6822(89)90151-7; PubMed=2705297 [NCBI, ExPASy, EBI, Israel, Japan] Sakaguchi T., Toyoda T., Gotoh B., Inocencio N.M., Kuma K., Miyata T., Nagai Y.; "Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene."; Virology 169:260-272(1989).

Comments

FUNCTION: Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).
FUNCTION: Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).
CATALYTIC ACTIVITY: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
SUBCELLULAR LOCATION: Virion membrane; Single-pass type II membrane protein (Potential). Cell membrane; Single-pass type II membrane protein (Potential).
SIMILARITY: Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

J03911; AAA46654.1; -; Genomic_RNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M24706; AAA46656.1; -; Genomic_RNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A31110; HNNZQD.
B46328; B46328.

3D structure databases

SMR

P13850; 124-572.

ModBase

P13850.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0019031;	Cellular component: viral envelope (inferred from electronic annotation from InterPro).
GO:0055036;	Cellular component: virion membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004308;	Molecular function: exo-alpha-sialidase activity (inferred from electronic annotation from InterPro).
GO:0046789;	Molecular function: host cell surface receptor binding (inferred from electronic annotation from InterPro).
GO:0019058;	Biological process: viral infectious cycle (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000665; Hemagglutn-neuramid_glycoprot.
IPR016285; Hemagglutn-neuramid_paramyxo.
Graphical view of domain structure.

Pfam

PF00423; HN; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF001072; Hemagglut-neuramid_paramyxoV; 1.

ProtoNet

P13850.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Envelope protein; Glycoprotein; Hemagglutinin; Hydrolase; Membrane; Signal-anchor; Transmembrane; Virion.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 616`	`616`	`Hemagglutinin-neuraminidase.`	`PRO_0000142617`
`TOPO_DOM`	`1 26`	`26`	`Cytoplasmic (Potential).`
`TRANSMEM`	`27 47`	`21`	`Potential.`
`TOPO_DOM`	`48 616`	`569`	`Extracellular (Potential).`
`CARBOHYD`	`119 119`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`341 341`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`433 433`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`481 481`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`538 538`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`600 600`		`N-linked (GlcNAc...) (Potential).`
`VARIANT`	`87 87`	`1`	`Q -> H.`
`VARIANT`	`113 113`	`1`	`R -> Q.`
`VARIANT`	`151 151`	`1`	`Y -> F.`
`VARIANT`	`432 432`	`1`	`S -> G.`
`VARIANT`	`495 495`	`1`	`K -> E.`

Sequence information

Length: 616 AA [This is the length of the unprocessed precursor]

Molecular weight: 67656 Da [This is the MW of the unprocessed precursor]

CRC64: CBF556EB3B8C060F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MDRAVSQVAL ENDEREAKNT WRLVFRIAIL LSTVVTLAIS AAALAYSMEA STPSDLVGIP 

        70         80         90        100        110        120 
TAISRAEEKI TSALGSNQDV VDRIYKQVAL ESPLALLNTE STIMNAITSL SYRINGAANS 

       130        140        150        160        170        180 
SGCGAPIHDP DYIGGIGKEL IVDDASDVTS YYPSAFQEHL NFIPAPTTGS GCTRIPSFDM 

       190        200        210        220        230        240 
SATHYCYTHN VILSGCRDHS HSHQYLALGV LRTSATGRVF FSTLRSINLD DTQNRKSCSV 

       250        260        270        280        290        300 
SATPLGCDML CSKVTETEEE DYNSAIPTSM VHGRLGFDGQ YHEKDLDVTT LFEDWVANYP 

       310        320        330        340        350        360 
GVGGGSFIDN RVWFPVYGGL KPNSPSDTAQ EGKYVIYKRY NDTCPDEQDY QIQMAKSSYK 

       370        380        390        400        410        420 
PGRFGGKRVQ QAILSIKVST SLGEDPVLTV PPNTVTLMGA EGRVLTVGTS HFLYQRGSSY 

       430        440        450        460        470        480 
FSPALLYPMI VSNKTATLHS PYTFNAFTRP GSVPCQASAR CPNSCVTGVY TDPYPLVFYR 

       490        500        510        520        530        540 
NHTLRGVFGT MLDDKQARLN PVSAVFDSIS RSRITRVSSS STKAAYTTST CFKVVKTNKT 

       550        560        570        580        590        600 
YCLSIAEISN TLFGEFRIVP LLVEILKDDG VREARSSRLS QLREGWKDDI VSPIFCDAKN 

       610 
QTEYRRELES YAASWP

P13850 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools