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UniProtKB/Swiss-Prot entry P13711


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACOX_YEAST
Primary accession number P13711
Secondary accession numbers None
Integrated into Swiss-Prot on January 1, 1990
Sequence was last modified on October 1, 1996 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 84)
Name and origin of the protein
Protein name Acyl-coenzyme A oxidase
Synonyms Acyl-CoA oxidase
EC 1.3.3.6
Gene name
Name: POX1
Synonyms: FOX1
OrderedLocusNames: YGL205W
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(90)90038-S; PubMed=2189786 [NCBI, ExPASy, EBI, Israel, Japan]
Dmochowska A., Dignard D., Maleszka R., Thomas D.Y.;
"Structure and transcriptional control of the Saccharomyces cerevisiae POX1 gene encoding acyl-coenzyme A oxidase.";
Gene 88:247-252(1990).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
PubMed=9169869 [NCBI, ExPASy, EBI, Israel, Japan]
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
Nature 387:81-84(1997).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-327.
DOI=10.1002/(SICI)1097-0061(199704)13:5<475::AID-YEA101>3.3.CO;2-S; PubMed=9153757 [NCBI, ExPASy, EBI, Israel, Japan]
Feuermann M., Simeonava L., Souciet J.-L., Potier S.;
"Analysis of 21.7 kb DNA sequence from the left arm of chromosome VII reveals 11 open reading frames: two correspond to new genes.";
Yeast 13:475-477(1997).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-6 AND SER-11, AND MASS SPECTROMETRY.
DOI=10.1038/nbt849; PubMed=12872131 [NCBI, ExPASy, EBI, Israel, Japan]
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D., Marsischky G., Roelofs J., Finley D., Gygi S.P.;
"A proteomics approach to understanding protein ubiquitination.";
Nat. Biotechnol. 21:921-926(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M27515; AAA34891.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z72727; CAA96918.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z72726; CAA96917.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S64224; S64224.
RefSeq NP_011310.1; -.
3D structure databases
HSSP P07872; 1IS2. [HSSP ENTRY / PDB]
ModBase P13711.
Protein-protein interaction databases
DIP DIP:6592N; -.
IntAct P13711; -.
Organism-specific databases
CYGD YGL205w; -.
SGD S000003173; POX1.
Yeast-GFP YGL205W.
Gene expression databases
ArrayExpress P13711; -.
GermOnline YGL205W; Saccharomyces cerevisiae.
Ontologies
GO
GO:0005777; Cellular component: peroxisome (inferred from electronic annotation from InterPro).
GO:0003995; Molecular function: acyl-CoA dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0003997; Molecular function: acyl-CoA oxidase activity (inferred from electronic annotation from InterPro).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0006635; Biological process: fatty acid beta-oxidation (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006091; Acyl-CoA_DHase/Oxase_M.
IPR012258; Acyl-CoA_oxidase.
IPR002655; Acyl_CoA_ox_C.
IPR013786; AcylCoA_DH/ox_N.
IPR013764; AcylCoA_oxidase/DH_1/2_C.
Graphical view of domain structure.
Gene3D G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 2.
PANTHER PTHR10909:SF11; Acyl-CoA_oxidase; 1.
Pfam PF01756; ACOX; 1.
PF02770; Acyl-CoA_dh_M; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000168; Acyl-CoA_oxidase; 1.
ProtoNet P13711.
Proteomic databases
PeptideAtlas P13711; -.
Genome annotation databases
Ensembl YGL205W; Saccharomyces cerevisiae. [Contig view]
GeneID 852667; -.
GenomeReviews Y13135_GR; YGL205W.
KEGG sce:YGL205W; -.
NMPDR fig|4932.3.peg.2413; -.
Phylogenomic databases
HOGENOM P13711; -.
Other
LinkHub P13711; -.
NextBio 971963; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Oxidoreductase; Peroxisome; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   748  748     Acyl-coenzyme A oxidase. PRO_0000204704
MOD_RES   6     6        Phosphothreonine. 
MOD_RES   11    11        Phosphoserine. 
CONFLICT   443   443        S -> T (in Ref. 1; AAA34891). 
Sequence information
Length: 748 AA [This is the length of the unprocessed precursor] Molecular weight: 84042 Da [This is the MW of the unprocessed precursor] CRC64: 5C0664455A050BDA [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTRRTTINPD SVVLNPQKFI QKERADSKIK VDQVNTFLES SPERRTLTHA LIDQIVNDPI 

        70         80         90        100        110        120 
LKTDTDYYDA KKMQEREITA KKIARLASYM EHDIKTVRKH FRDTDLMKEL QANDPDKASP 

       130        140        150        160        170        180 
LTNKDLFIFD KRLSLVANID PQLGTRVGVH LGLFGNCIKG NGTDEQIRYW LQERGATLMK 

       190        200        210        220        230        240 
GIYGCFAMTE LGHGSNVAQL QTRAVYDKQN DTFVIDTPDL TATKWWIGGA AHSATHAAVY 

       250        260        270        280        290        300 
ARLIVEGKDY GVKTFVVPLR DPSTFQLLAG VSIGDIGAKM GRDGIDNGWI QFRNVVIPRE 

       310        320        330        340        350        360 
FMLSRFTKVV RSPDGSVTVK TEPQLDQISG YSALLSGRVN MVMDSFRFGS KFATIAVRYA 

       370        380        390        400        410        420 
VGRQQFAPRK GLSETQLIDY PLHQYRVLPQ LCVPYLVSPV AFKLMDNYYS TLDELYNASS 

       430        440        450        460        470        480 
SAYKAALVTV SKKLKNLFID SASLKATNTW LIATLIDELR QTCGGHGYSQ YNGFGKGYDD 

       490        500        510        520        530        540 
WVVQCTWEGD NNVLSLTSAK SILKKFIDSA TKGRFDNTLD VDSFSYLKPQ YIGSVVSGEI 

       550        560        570        580        590        600 
KSGLKELGDY TEIWSITLIK LLAHIGTLVE KSRSIDSVSK LLVLVSKFHA LRCMLKTYYD 

       610        620        630        640        650        660 
KLNSRDSHIS DEITKESMWN VYKLFSLYFI DKHSGEFQQF KIFTPDQISK VVQPQLLALL 

       670        680        690        700        710        720 
PIVRKDCIGL TDSFELPDAM LNSPIGYFDG DIYHNYFNEV CRNNPVEADG AGKPSYHALL 

       730        740 
SSMLGRGFEF DQKLGGAANA EILSKINK 

P13711 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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