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UniProtKB/Swiss-Prot entry P13591


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NCAM1_HUMAN
Primary accession number P13591
Secondary accession numbers A8K8T8 P13592 P13593 Q05C58 Q15829 Q16180 Q16209 Q59FL7 Q86X47 Q96CJ3
Integrated into Swiss-Prot on January 1, 1990
Sequence was last modified on July 22, 2008 (Sequence version 3)
Annotations were last modified on    June 16, 2009 (Entry version 107)
Name and origin of the protein
Protein name Neural cell adhesion molecule 1 [Precursor]
Synonyms NCAM-1
N-CAM-1
CD56 antigen
Gene name
Name: NCAM1
Synonyms: NCAM
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
TISSUE=Skeletal muscle;
PubMed=3253057 [NCBI, ExPASy, EBI, Israel, Japan]
Barton C.H., Dickson G., Gower H.J., Rowett L.H., Putt W., Elsom V., Moore S.E., Goridis C., Walsh F.S.;
"Complete sequence and in vitro expression of a tissue-specific phosphatidylinositol-linked N-CAM isoform from skeletal muscle.";
Development 104:165-173(1988).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
PubMed=1710251 [NCBI, ExPASy, EBI, Israel, Japan]
Lanier L.L., Chang C., Azuma M., Ruitenberg J.J., Hemperly J.J., Phillips J.H.;
"Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56).";
J. Immunol. 146:4421-4426(1991).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
DOI=10.1016/0169-5002(94)90660-2; PubMed=8075973 [NCBI, ExPASy, EBI, Israel, Japan]
Saito S., Tanio Y., Tachibana I., Hayashi S., Kishimoto T., Kawase I.;
"Complementary DNA sequence encoding the major neural cell adhesion molecule isoform in a human small cell lung cancer cell line.";
Lung Cancer 10:307-318(1994).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Testis;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
TISSUE=Brain;
Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.;
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6), AND VARIANT ASP-679.
TISSUE=Brain, Kidney, and Ovary;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 347-369.
DOI=10.1002/ijc.2910500124; PubMed=1339414 [NCBI, ExPASy, EBI, Israel, Japan]
van Duijnhoven H.L., Helfrich W., de Leij L., Roebroek A.J., van de Ven W.J., Healey K., Culverwell A., Rossell R.J., Kemshead J.T., Patel K.;
"Splicing of the VASE exon of neural cell adhesion molecule (NCAM) in human small-cell lung carcinoma (SCLC).";
Int. J. Cancer 50:118-123(1992).
[8]
NUCLEOTIDE SEQUENCE [MRNA] OF 501-858 (ISOFORM 1/2 AND ISOFORM 3).
TISSUE=Skeletal muscle;
DOI=10.1016/0092-8674(87)90178-4; PubMed=2887295 [NCBI, ExPASy, EBI, Israel, Japan]
Dickson G., Gower H.J., Barton C.H., Prentice H.M., Elsom V.L., Moore S.E., Cox R.D., Quinn C., Putt W., Walsh F.S.;
"Human muscle neural cell adhesion molecule (N-CAM): identification of a muscle-specific sequence in the extracellular domain.";
Cell 50:1119-1130(1987).
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 501-858 (ISOFORM 5).
DOI=10.1016/0092-8674(88)90241-3; PubMed=3203385 [NCBI, ExPASy, EBI, Israel, Japan]
Gower H.J., Barton C.H., Elsom V.L., Thompson J., Moore S.E., Dickson G., Walsh F.S.;
"Alternative splicing generates a secreted form of N-CAM in muscle and brain.";
Cell 55:955-964(1988).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-784, AND MASS SPECTROMETRY.
TISSUE=Brain cortex;
DOI=10.1021/pr0498436; PubMed=15822905 [NCBI, ExPASy, EBI, Israel, Japan]
DeGiorgis J.A., Jaffe H., Moreira J.E., Carlotti C.G. Jr., Leite J.P., Pant H.C., Dosemeci A.;
"Phosphoproteomic analysis of synaptosomes from human cerebral cortex.";
J. Proteome Res. 4:306-315(2005).
[11]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-459, AND MASS SPECTROMETRY.
TISSUE=Plasma;
DOI=10.1021/pr0502065; PubMed=16335952 [NCBI, ExPASy, EBI, Israel, Japan]
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.;
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.";
J. Proteome Res. 4:2070-2080(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X16841; CAA34739.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U63041; AAB04558.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S71824; AAB31836.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK292453; BAF85142.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB209443; BAD92680.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC014205; AAH14205.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC029119; AAH29119.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC047244; AAH47244.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S73101; AAB20698.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M17410; AAA59913.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M17409; AAA59912.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M22094; AAA59910.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M22092; AAA59911.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M22091; AAA59911.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00220737; -.
IPI00411478; -.
IPI00435020; -.
IPI00795918; -.
IPI00900302; -.
IPI00900340; -.
PIR A31635; A31635.
I54773; I54773.
S07784; IJHUNG.
RefSeq NP_000606.3; -.
NP_001070150.1; -.
NP_851996.2; -.
UniGene Hs.503878
3D structure databases
PDB
2E3V; X-ray; 1.95 A; A/B/C=510-608.[ExPASy / RCSB / EBI]
2HAZ; X-ray; 1.70 A; A=508-608.[ExPASy / RCSB / EBI]
2VKW; X-ray; 2.30 A; A/B=506-702.[ExPASy / RCSB / EBI]
2VKX; X-ray; 2.70 A; A/B/C/D/E/F=506-702.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 2E3V; -.
2HAZ; -.
2VKW; -.
2VKX; -.
SMR P13591; 20-307, 602-695.
ModBase P13591.
PTM databases
PhosphoSite P13591; -.
Enzyme and pathway databases
Pathway_Interaction_DB fgf_pathway; FGF signaling pathway.
Organism-specific databases
GeneCards GC11P112337; -.
H-InvDB HIX0010129; -.
HGNC HGNC:7656; NCAM1.
GenAtlas NCAM1.
HPA CAB000142; -.
CAB018071; -.
MIM 116930; gene. [NCBI / EBI]
PharmGKB PA31459; -.
Gene expression databases
ArrayExpress P13591; -.
Bgee P13591; -.
GermOnline ENSG00000149294; Homo sapiens.
Ontologies
GO
GO:0031225; Cellular component: anchored to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021; Cellular component: integral to membrane (traceable author statement from ProtInc).
GO:0005886; Cellular component: plasma membrane (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from electronic annotation from UniProtKB-KW).
GO:0007155; Biological process: cell adhesion (non-traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR008957; Fibronectin_typ-III-like_fold.
IPR003961; FN_III.
IPR013151; Ig.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR009138; Neural_cell_adh.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.30; FN_III-like; 2.
G3DSA:2.60.40.10; Ig-like_fold; 4.
Pfam PF00041; fn3; 2.
PF07679; I-set; 3.
PF00047; ig; 2.
Pfam graphical view of domain structure.
PRINTS PR01838; NCAMFAMILY.
SMART SM00060; FN3; 2.
SM00408; IGc2; 4.
SMART graphical view of domain structure.
PROSITE PS50853; FN3; 2.
PS50835; IG_LIKE; 5.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSG00000149294; Homo sapiens. [Contig view]
GeneID 4684; -.
KEGG hsa:4684; -.
Phylogenomic databases
HOVERGEN P13591; -.
Other
NextBio 18060; -.
SOURCE NCAM1; Homo sapiens.
ProtoNet P13591.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain; Lipoprotein; Membrane; Phosphoprotein; Polymorphism; Repeat; Secreted; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    19  19     By similarity. 
CHAIN   20   858  839     Neural cell adhesion molecule 1. PRO_0000015009
TOPO_DOM   20   718  699     Extracellular (Potential). 
TRANSMEM   719   739  21     Potential. 
TOPO_DOM   740   858  119     Cytoplasmic (Potential). 
DOMAIN   20   111  92     Ig-like C2-type 1. 
DOMAIN   116   205  90     Ig-like C2-type 2. 
DOMAIN   212   301  90     Ig-like C2-type 3. 
DOMAIN   308   413  106     Ig-like C2-type 4. 
DOMAIN   416   501  86     Ig-like C2-type 5. 
DOMAIN   506   605  100     Fibronectin type-III 1. 
DOMAIN   608   702  95     Fibronectin type-III 2. 
MOD_RES   784   784        Phosphoserine. 
CARBOHYD   222   222        N-linked (GlcNAc...) (Potential). 
CARBOHYD   315   315        N-linked (GlcNAc...) (Potential). 
CARBOHYD   347   347        N-linked (GlcNAc...) (Potential). 
CARBOHYD   433   433        N-linked (GlcNAc...) (Potential). 
CARBOHYD   459   459        N-linked (GlcNAc...). 
CARBOHYD   488   488        N-linked (GlcNAc...) (Potential). 
DISULFID   41    96        Probable. 
DISULFID   139   189        Probable. 
DISULFID   235   287        Probable. 
DISULFID   329   395        Probable. 
DISULFID   436   489        Probable. 
VAR_SEQ   354   363        Missing (in isoform 2, isoform 3 and isoform 4). VSP_034818
VAR_SEQ   364   364        T -> V (in isoform 6). VSP_034819
VAR_SEQ   365   858        Missing (in isoform 6). VSP_034820
VAR_SEQ   609   665        QGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVR YRALSSEWKPEIRLPSG -> HSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAKNIAQ NHCCNMFQAGLHNALMK (in isoform 5). VSP_034821
VAR_SEQ   609   609        Q -> HSPPPPASASSSTPVPLSPPDTTWPLPALATTEPAK (in isoform 3). VSP_034822
VAR_SEQ   666   858        Missing (in isoform 5). VSP_034823
VAR_SEQ   712   736        NGSPTSGLSTGAIVGILIVIFVLLL -> TLGGNSASYTFVSLLFSAVTLLLLC (in isoform 3 and isoform 4). VSP_034824
VAR_SEQ   737   858        Missing (in isoform 3 and isoform 4). VSP_034825
VARIANT   260   260  1     D -> N (in dbSNP:rs17115160 [NCBI]). VAR_049960 [3D]
VARIANT   679   679  1     E -> D (in dbSNP:rs17115280 [NCBI]). VAR_049961 
VARIANT   834   834  1     T -> M (in dbSNP:rs17174409 [NCBI]). VAR_049962 
CONFLICT   215   215        Q -> R (in Ref. 2; AAB04558). 
CONFLICT   239   239        G -> R (in Ref. 2; AAB04558). 
CONFLICT   500   500        L -> F (in Ref. 2; AAB04558). 
CONFLICT   560   560        Y -> H (in Ref. 4; BAF85142). 
CONFLICT   609   610        QG -> R (in Ref. 8; AAA59913). 
CONFLICT   730   731        Missing (in Ref. 8; AAA59913). 
CONFLICT   821   821        G -> A (in Ref. 8; AAA59913). 
CONFLICT   856   856        S -> N (in Ref. 6; AAH47244). 
STRAND   504   510  7      
STRAND   515   520  6      
STRAND   532   541  10      
STRAND   546   551  6      
HELIX   552   558  7      
STRAND   559   563  5      
STRAND   571   580  10      
STRAND   591   594  4      
STRAND   606   611  6      
STRAND   618   623  6      
STRAND   634   641  8      
STRAND   650   652  3      
STRAND   658   661  4      
STRAND   669   678  10      
STRAND   686   691  6      
Sequence information
Length: 858 AA [This is the length of the unprocessed precursor] Molecular weight: 94574 Da [This is the MW of the unprocessed precursor] CRC64: FD3B9DE80D802554 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLQTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK DISWFSPNGE 

        70         80         90        100        110        120 
KLTPNQQRIS VVWNDDSSST LTIYNANIDD AGIYKCVVTG EDGSESEATV NVKIFQKLMF 

       130        140        150        160        170        180 
KNAPTPQEFR EGEDAVIVCD VVSSLPPTII WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK 

       190        200        210        220        230        240 
KTDEGTYRCE GRILARGEIN FKDIQVIVNV PPTIQARQNI VNATANLGQS VTLVCDAEGF 

       250        260        270        280        290        300 
PEPTMSWTKD GEQIEQEEDD EKYIFSDDSS QLTIKKVDKN DEAEYICIAE NKAGEQDATI 

       310        320        330        340        350        360 
HLKVFAKPKI TYVENQTAME LEEQVTLTCE ASGDPIPSIT WRTSTRNISS EEKASWTRPE 

       370        380        390        400        410        420 
KQETLDGHMV VRSHARVSSL TLKSIQYTDA GEYICTASNT IGQDSQSMYL EVQYAPKLQG 

       430        440        450        460        470        480 
PVAVYTWEGN QVNITCEVFA YPSATISWFR DGQLLPSSNY SNIKIYNTPS ASYLEVTPDS 

       490        500        510        520        530        540 
ENDFGNYNCT AVNRIGQESL EFILVQADTP SSPSIDQVEP YSSTAQVQFD EPEATGGVPI 

       550        560        570        580        590        600 
LKYKAEWRAV GEEVWHSKWY DAKEASMEGI VTIVGLKPET TYAVRLAALN GKGLGEISAA 

       610        620        630        640        650        660 
SEFKTQPVQG EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVRYR ALSSEWKPEI 

       670        680        690        700        710        720 
RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF RTSAQPTAIP ANGSPTSGLS 

       730        740        750        760        770        780 
TGAIVGILIV IFVLLLVVVD ITCYFLNKCG LFMCIAVNLC GKAGPGAKGK DMEEGKAAFS 

       790        800        810        820        830        840 
KDESKEPIVE VRTEEERTPN HDGGKHTEPN ETTPLTEPEK GPVEAKPECQ ETETKPAPAE 

       850 
VKTVPNDATQ TKENESKA 

P13591 in FASTA format

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