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UniProtKB/Swiss-Prot entry P13586


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATC1_YEAST
Primary accession number P13586
Secondary accession numbers None
Integrated into Swiss-Prot on January 1, 1990
Sequence was last modified on January 1, 1990 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 93)
Name and origin of the protein
Protein name Calcium-transporting ATPase 1
Synonyms EC 3.6.3.8
Golgi Ca(2+)-ATPase
Gene name
Name: PMR1
Synonyms: BSD1, SCC1
OrderedLocusNames: YGL167C
ORFNames: G1666
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0092-8674(89)90410-8; PubMed=2526682 [NCBI, ExPASy, EBI, Israel, Japan]
Rudolph H.K., Antebi A., Fink G.R., Buckley C.M., Dorman T.E., Levitre J., Davidow L.S., Mao J.-I., Moir D.T.;
"The yeast secretory pathway is perturbed by mutations in PMR1, a member of a Ca2+ ATPase family.";
Cell 58:133-145(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
DOI=10.1002/(SICI)1097-0061(199609)12:10B<1033::AID-YEA983>3.3.CO;2-M; PubMed=8896267 [NCBI, ExPASy, EBI, Israel, Japan]
Klima R., Coglievina M., Zaccaria P., Bertani I., Bruschi C.V.;
"A putative helicase, the SUA5, PMR1, tRNALys1 genes and four open reading frames have been detected in the DNA sequence of an 8.8 kb fragment of the left arm of chromosome VII of Saccharomyces cerevisiae.";
Yeast 12:1033-1040(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
PubMed=9169869 [NCBI, ExPASy, EBI, Israel, Japan]
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
Nature 387:81-84(1997).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 863-950.
PubMed=1325384 [NCBI, ExPASy, EBI, Israel, Japan]
Na J.G., Pinto I., Hampsey M.;
"Isolation and characterization of SUA5, a novel gene required for normal growth in Saccharomyces cerevisiae.";
Genetics 131:791-801(1992).
[5]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[6]
TOPOLOGY [LARGE SCALE ANALYSIS].
DOI=10.1073/pnas.0604075103; PubMed=16847258 [NCBI, ExPASy, EBI, Israel, Japan]
Kim H., Melen K., Oesterberg M., von Heijne G.;
"A global topology map of the Saccharomyces cerevisiae membrane proteome.";
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M25488; AAA34884.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X85757; CAA59762.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z72690; CAA96880.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X64319; CAA45599.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A30990; PWBYR1.
RefSeq NP_011348.1; -.
3D structure databases
HSSP P04191; 1EUL. [HSSP ENTRY / PDB]
ModBase P13586.
Protein-protein interaction databases
DIP DIP:7899N; -.
Organism-specific databases
CYGD YGL167c; -.
SGD S000003135; PMR1.
Yeast-GFP YGL167C.
Gene expression databases
ArrayExpress P13586; -.
GermOnline YGL167C; Saccharomyces cerevisiae.
Ontologies
GO
GO:0000139; Cellular component: Golgi membrane (inferred from direct assay from SGD).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005388; Molecular function: calcium-transporting ATPase activity (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0015410; Molecular function: manganese-transporting ATPase activity (inferred from direct assay from SGD).
GO:0006816; Biological process: calcium ion transport (inferred from electronic annotation from InterPro).
GO:0006887; Biological process: exocytosis (inferred from genetic interaction from SGD).
GO:0006828; Biological process: manganese ion transport (inferred from direct assay from SGD).
GO:0006486; Biological process: protein amino acid glycosylation (inferred from mutant phenotype from SGD).
GO:0015992; Biological process: proton transport (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR006413; ATPase-IIA2_Ca.
IPR001757; ATPase_P.
IPR006068; ATPase_P_cat_C.
IPR004014; ATPase_P_cat_N.
IPR005834; Dehalogen-like_hydro.
IPR008250; E1-E2_ATPase_reg.
IPR000695; H_ATPase.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00689; Cation_ATPase_C; 1.
PF00690; Cation_ATPase_N; 1.
PF00122; E1-E2_ATPase; 1.
PF00702; Hydrolase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
PR00120; HATPASE.
TIGRFAMs TIGR01522; ATPase-IIA2_Ca; 1.
TIGR01494; ATPase_P-type; 3.
PROSITE PS00154; ATPASE_E1_E2; 1.
ProtoNet P13586.
Proteomic databases
PeptideAtlas P13586; -.
Genome annotation databases
Ensembl YGL167C; Saccharomyces cerevisiae. [Contig view]
GeneID 852709; -.
GenomeReviews Y13135_GR; YGL167C.
KEGG sce:YGL167C; -.
NMPDR fig|4932.3.peg.2452; -.
Phylogenomic databases
HOGENOM P13586; -.
Other
LinkHub P13586; -.
NextBio 972070; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Calcium; Calcium transport; Complete proteome; Golgi apparatus; Hydrolase; Ion transport; Magnesium; Membrane; Nucleotide-binding; Phosphoprotein; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   950  950     Calcium-transporting ATPase 1. PRO_0000046231
TOPO_DOM   1    92  92     Cytoplasmic (Potential). 
TRANSMEM   93   111  19     Potential. 
TOPO_DOM   112   116  5     Lumenal (Potential). 
TRANSMEM   117   133  17     Potential. 
TOPO_DOM   134   288  155     Cytoplasmic (Potential). 
TRANSMEM   289   309  21     Potential. 
TOPO_DOM   310   323  14     Lumenal (Potential). 
TRANSMEM   324   344  21     Potential. 
TOPO_DOM   345   814  470     Cytoplasmic (Potential). 
TRANSMEM   815   835  21     Potential. 
TOPO_DOM   836   844  9     Lumenal (Potential). 
TRANSMEM   845   862  18     Potential. 
TOPO_DOM   863   884  22     Cytoplasmic (Potential). 
TRANSMEM   885   905  21     Potential. 
TOPO_DOM   906   909  4     Lumenal (Potential). 
TRANSMEM   910   930  21     Potential. 
TOPO_DOM   931   950  20     Cytoplasmic (Potential). 
ACT_SITE   371   371        4-aspartylphosphate intermediate (By similarity). 
Sequence information
Length: 950 AA [This is the length of the unprocessed precursor] Molecular weight: 104571 Da [This is the MW of the unprocessed precursor] CRC64: 0A88271FBD6870B8 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSDNPFNASL LDEDSNRERE ILDATAEALS KPSPSLEYCT LSVDEALEKL DTDKNGGLRS 

        70         80         90        100        110        120 
SNEANNRRSL YGPNEITVED DESLFKKFLS NFIEDRMILL LIGSAVVSLF MGNIDDAVSI 

       130        140        150        160        170        180 
TLAIFIVVTV GFVQEYRSEK SLEALNKLVP AECHLMRCGQ ESHVLASTLV PGDLVHFRIG 

       190        200        210        220        230        240 
DRIPADIRII EAIDLSIDES NLTGENEPVH KTSQTIEKSS FNDQPNSIVP ISERSCIAYM 

       250        260        270        280        290        300 
GTLVKEGHGK GIVVGTGTNT SFGAVFEMMN NIEKPKTPLQ LTMDKLGKDL SLVSFIVIGM 

       310        320        330        340        350        360 
ICLVGIIQGR SWLEMFQISV SLAVAAIPEG LPIIVTVTLA LGVLRMAKRK AIVRRLPSVE 

       370        380        390        400        410        420 
TLGSVNVICS DKTGTLTSNH MTVSKLWCLD SMSNKLNVLS LDKNKKTKNS NGNLKNYLTE 

       430        440        450        460        470        480 
DVRETLTIGN LCNNASFSQE HAIFLGNPTD VALLEQLANF EMPDIRNTVQ KVQELPFNSK 

       490        500        510        520        530        540 
RKLMATKILN PVDNKCTVYV KGAFERILEY STSYLKSKGK KTEKLTEAQK ATINECANSM 

       550        560        570        580        590        600 
ASEGLRVFGF AKLTLSDSST PLTEDLIKDL TFTGLIGMND PPRPNVKFAI EQLLQGGVHI 

       610        620        630        640        650        660 
IMITGDSENT AVNIAKQIGI PVIDPKLSVL SGDKLDEMSD DQLANVIDHV NIFARATPEH 

       670        680        690        700        710        720 
KLNIVRALRK RGDVVAMTGD GVNDAPALKL SDIGVSMGRI GTDVAKEASD MVLTDDDFST 

       730        740        750        760        770        780 
ILTAIEEGKG IFNNIQNFLT FQLSTSVAAL SLVALSTAFK LPNPLNAMQI LWINILMDGP 

       790        800        810        820        830        840 
PAQSLGVEPV DHEVMKKPPR KRTDKILTHD VMKRLLTTAA CIIVGTVYIF VKEMAEDGKV 

       850        860        870        880        890        900 
TARDTTMTFT CFVFFDMFNA LACRHNTKSI FEIGFFTNKM FNYAVGLSLL GQMCAIYIPF 

       910        920        930        940        950 
FQSIFKTEKL GISDILLLLL ISSSVFIVDE LRKLWTRKKN EEDSTYFSNV 

P13586 in FASTA format

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