ID   NEU1_SHEEP              Reviewed;         125 AA.
AC   P13389; P01188;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   10-JUN-2008, entry version 61.
DE   Oxytocin-neurophysin 1 precursor (OT-NPI) [Contains: Oxytocin
DE   (Ocytocin); Neurophysin 1].
GN   Name=OXT;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Corpus luteum;
RX   MEDLINE=90016886; PubMed=2798140; DOI=10.1093/nar/17.19.7990;
RA   Jones D.S.C., Flint A.P.F.;
RT   "Nucleotide sequence of a full length cDNA clone encoding the
RT   oxytocin-neurophysin I precursor isolated from the ovine corpus
RT   luteum.";
RL   Nucleic Acids Res. 17:7990-7990(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Ovary;
RX   MEDLINE=91252497; PubMed=2095591;
RA   Ivell R., Hunt N., Abend N., Brackman B., Nollmeyer D., Lamsa J.C.,
RA   McCracken J.A.;
RT   "Structure and ovarian expression of the oxytocin gene in sheep.";
RL   Reprod. Fertil. Dev. 2:703-711(1990).
RN   [3]
RP   PROTEIN SEQUENCE OF 20-28.
RA   Acher R., Chauvet J., Lenci M.T.;
RT   "Purification and structure of sheep oxytocin and vasopressin.";
RL   C.R. Hebd. Seances Acad. Sci., D, Sci. Nat. 248:1435-1438(1959).
CC   -!- FUNCTION: Neurophysin 1 specifically binds oxytocin.
CC   -!- FUNCTION: Oxytocin causes contraction of the smooth muscle of the
CC       uterus and of the mammary gland.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family.
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DR   EMBL; X16052; CAA34184.1; -; mRNA.
DR   EMBL; X16052; CAA34185.1; ALT_SEQ; mRNA.
DR   EMBL; X16052; CAA34186.1; ALT_INIT; mRNA.
DR   EMBL; X55131; CAA38924.1; -; Genomic_DNA.
DR   PIR; S06086; NFSH1.
DR   UniGene; Oar.444; -.
DR   SMR; P13389; 32-123.
DR   HOVERGEN; P13389; -.
DR   LinkHub; P13389; -.
DR   InterPro; IPR000981; Neurhyp_horm.
DR   InterPro; IPR016321; Nonapeptide_hormone_prcur.
DR   Gene3D; G3DSA:2.60.9.10; Neurhyp_horm; 1.
DR   Pfam; PF00220; Hormone_4; 1.
DR   Pfam; PF00184; Hormone_5; 1.
DR   PIRSF; PIRSF001815; Nonapeptide_hormone_precursor; 1.
DR   PRINTS; PR00831; NEUROPHYSIN.
DR   ProDom; PD001676; Neurhyp_horm; 1.
DR   SMART; SM00003; NH; 1.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Hormone; Signal.
FT   SIGNAL        1     19
FT   PEPTIDE      20     28       Oxytocin.
FT                                /FTId=PRO_0000020505.
FT   CHAIN        32    125       Neurophysin 1.
FT                                /FTId=PRO_0000020506.
FT   MOD_RES      28     28       Glycine amide.
FT   DISULFID     20     25
FT   DISULFID     41     85       By similarity.
FT   DISULFID     44     58       By similarity.
FT   DISULFID     52     75       By similarity.
FT   DISULFID     59     65       By similarity.
FT   DISULFID     92    104       By similarity.
FT   DISULFID     98    116       By similarity.
FT   DISULFID    105    110       By similarity.
FT   CONFLICT     48     48       G -> A (in Ref. 1; CAA34184/CAA34186).
FT   CONFLICT    110    110       C -> S (in Ref. 1; CAA34184/CAA34186).
SQ   SEQUENCE   125 AA;  12635 MW;  3B4C05141422E432 CRC64;
     MAGSSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDVRT CLPCGPGGKG RCFGPSICCG
     DELGCFVGTA EALRCREENY LPSPCQSGQK PCGSGGRCAA AGICCSPDGC HADPACDPEA
     AFSQH
//