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UniProtKB/Swiss-Prot entry P13073


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name COX41_HUMAN
Primary accession number P13073
Secondary accession numbers None
Integrated into Swiss-Prot on January 1, 1990
Sequence was last modified on January 1, 1990 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 98)
Name and origin of the protein
Protein name Cytochrome c oxidase subunit 4 isoform 1, mitochondrial [Precursor]
Synonyms Cytochrome c oxidase subunit IV isoform 1
COX IV-1
Cytochrome c oxidase polypeptide IV
Gene name
Name: COX4I1
Synonyms: COX4
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
DOI=10.1016/0378-1119(87)90281-2; PubMed=2444497 [NCBI, ExPASy, EBI, Israel, Japan]
Zeviani M., Nakagawa M., Herbert J., Lomax M.I., Grossman L.I., Sherbany A.A., Miranda A.F., Dimauro S., Schon E.A.;
"Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase.";
Gene 55:205-217(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0378-1119(90)90281-U; PubMed=2157630 [NCBI, ExPASy, EBI, Israel, Japan]
Lomax M.I., Welch M.D., Darras B.T., Francke U., Grossman L.I.;
"Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV.";
Gene 86:209-216(1990).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Skeletal muscle;
Park S.J., Modica-Napolitano J., Gross A., Ernst S.G., Aprille J.R.;
Submitted (OCT-1990) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.;
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Placenta;
Bachman N.J., Wu W., Grossman L.I., Lomax M.I.;
"The COX4 gene and a linked gene, COX4AL, are controlled by a bidirectional promoter.";
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Poyau A., Godinot C.;
"COX4, the human cytochrome c oxidase subunit IV gene.";
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=B-cell, and Ovary;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-169.
DOI=10.1007/s003359901031; PubMed=10337626 [NCBI, ExPASy, EBI, Israel, Japan]
Bachman N.J., Wu W., Schmidt T.R., Grossman L.I., Lomax M.I.;
"The 5-prime region of the COX4 gene contains a novel overlapping gene, NOC4.";
Mamm. Genome 10:506-512(1999).
[10]
PROTEIN SEQUENCE OF 23-72.
TISSUE=Heart, and Muscle;
DOI=10.1016/0167-4838(92)90395-T; PubMed=1311608 [NCBI, ExPASy, EBI, Israel, Japan]
van Kuilenburg A.B.P., van Beeumen J.J., Demol H., van den Bogert C., Schouten I., Muijsers A.O.;
"Subunit IV of human cytochrome c oxidase, polymorphism and a putative isoform.";
Biochim. Biophys. Acta 1119:218-224(1992).
[11]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M21575; AAA99312.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M34600; AAA52059.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X54802; CAA38573.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U90915; AAB51058.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF005889; AAB94819.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF017115; AAC99578.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF042746; AAB97750.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF042744; AAB97750.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF042745; AAB97750.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT019825; AAV38628.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC008704; AAH08704.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC021236; AAH21236.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00006579; -.
PIR S47012; OLHU4.
RefSeq NP_001852.1; -.
UniGene Hs.433419
3D structure databases
SMR P13073; 26-169.
ModBase P13073.
Protein-protein interaction databases
IntAct P13073; 3.
Protein family/group databases
TCDB 3.D.4.11.1; proton-translocating cytochrome oxidase (COX) superfamily.
PTM databases
PhosphoSite P13073; -.
Enzyme and pathway databases
Reactome REACT_6305; Electron Transport Chain.
Organism-specific databases
GeneCards GC16P084390; -.
H-InvDB HIX0013312; -.
HIX0040518; -.
HGNC HGNC:2265; COX4I1.
GenAtlas COX4I1.
HPA CAB004080; -.
HPA002485; -.
MIM 123864; gene. [NCBI / EBI]
PharmGKB PA26781; -.
Gene expression databases
ArrayExpress P13073; -.
Bgee P13073; -.
CleanEx HS_COX4I1; -.
GermOnline ENSG00000131143; Homo sapiens.
Ontologies
GO
GO:0005743; Cellular component: mitochondrial inner membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005634; Cellular component: nucleus (inferred from direct assay from HPA).
GO:0004129; Molecular function: cytochrome-c oxidase activity (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0006091; Biological process: generation of precursor metabolites and energy (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR004203; Cyt_c_oxidase_su4.
IPR013288; Cyt_c_oxidase_su4_sub.
Graphical view of domain structure.
Gene3D G3DSA:1.10.442.10; COX4; 1.
Pfam PF02936; COX4; 1.
Pfam graphical view of domain structure.
PRINTS PR01873; CYTCOXIDASE4.
Proteomic databases
PeptideAtlas P13073; -.
PRIDE P13073; -.
Genome annotation databases
Ensembl ENSG00000131143; Homo sapiens. [Contig view]
GeneID 1327; -.
KEGG hsa:1327; -.
Phylogenomic databases
HOGENOM P13073; -.
HOVERGEN P13073; -.
OMA P13073; WSSLSID.
Other
NextBio 5407; -.
SOURCE COX4I1; Homo sapiens.
ProtoNet P13073.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Polymorphism; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
TRANSIT   1    22  22     Mitochondrion. 
CHAIN   23   169  147     Cytochrome c oxidase subunit 4 isoform 1, mitochondrial. PRO_0000006084
VARIANT   38    38  1     Y -> F. VAR_002170 [3D]
Sequence information
Length: 169 AA [This is the length of the unprocessed precursor] Molecular weight: 19577 Da [This is the MW of the unprocessed precursor] CRC64: F6382FFDCF3BE4ED [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA HVKHLSASQK 

        70         80         90        100        110        120 
ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW KTVVGGAMFF IGFTALVIMW 

       130        140        150        160 
QKHYVYGPLP QSFDKEWVAK QTKRMLDMKV NPIQGLASKW DYEKNEWKK 

P13073 in FASTA format

View entry in raw text format (no links)
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