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UniProtKB/Swiss-Prot entry P12967


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IAPP_FELCA
Primary accession number P12967
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1989
Sequence was last modified on October 1, 1989 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 60)
Name and origin of the protein
Protein name Islet amyloid polypeptide [Precursor]
Synonym Amylin
Gene name
Name: IAPP
From
Felis silvestris catus (Cat) [TaxID: 9685] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1073/pnas.86.15.5738; PubMed=2668946 [NCBI, ExPASy, EBI, Israel, Japan]
Nishi M., Chan S.J., Nagamatsu S., Bell G.I., Steiner D.F.;
"Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone.";
Proc. Natl. Acad. Sci. U.S.A. 86:5738-5742(1989).
[2]
PROTEIN SEQUENCE OF 34-60.
DOI=10.1073/pnas.84.11.3881; PubMed=3035556 [NCBI, ExPASy, EBI, Israel, Japan]
Westermark P., Wernstedt C., Wilander E., Hayden D.W., O'Brien T.D., Johnson K.H.;
"Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.";
Proc. Natl. Acad. Sci. U.S.A. 84:3881-3885(1987).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 34-70.
PubMed=2210054 [NCBI, ExPASy, EBI, Israel, Japan]
Betsholtz C., Christmanson L., Engstrom U., Rorsman F., Jordan K., O'Brien T.D., Murtaugh M., Johnson K.H., Westermark P.;
"Structure of cat islet amyloid polypeptide and identification of amino acid residues of potential significance for islet amyloid formation.";
Diabetes 39:118-122(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M25388; AAA30813.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A33542; A33542.
RefSeq NP_001036803.1; -.
3D structure databases
ModBase P12967.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005179; Molecular function: hormone activity (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001693; Calcitonin-like.
IPR018360; Calcitonin_CS.
IPR000443; Islet_amyloid_polypep.
Graphical view of domain structure.
PANTHER PTHR10505; Calcitonin-like; 1.
Pfam PF00214; Calc_CGRP_IAPP; 1.
Pfam graphical view of domain structure.
PRINTS PR00818; ISLETAMYLOID.
SMART SM00113; CALCITONIN; 1.
SMART graphical view of domain structure.
PROSITE PS00258; CALCITONIN; 1.
Genome annotation databases
GeneID 751513; -.
Phylogenomic databases
HOVERGEN P12967; -.
Other
ProtoNet P12967.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amidation; Amyloid; Cleavage on pair of basic residues; Direct protein sequencing; Disulfide bond; Hormone; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
SIGNAL   1   22  22     Potential. 
PROPEP   23   31  9      PRO_0000004102
PEPTIDE   34   70  37     Islet amyloid polypeptide. PRO_0000004103
PROPEP   74   89  16      PRO_0000004104
MOD_RES   70   70        Tyrosine amide (By similarity). 
DISULFID   35   40        By similarity. 
Sequence information
Length: 89 AA [This is the length of the unprocessed precursor] Molecular weight: 9832 Da [This is the MW of the unprocessed precursor] CRC64: 0834D783DEAD72A8 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MCLLKLPVVL IVLLVALHHL KATPIESNQV EKRKCNTATC ATQRLANFLI RSSNNLGAIL 

        70         80 
SPTNVGSNTY GKRSTVDILN REPLNYLPF 

P12967 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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NPSA logo NPSA Sequence analysis tools

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