ID   MOTI_HUMAN              Reviewed;         115 AA.
AC   P12872; Q6NSY7;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   01-JUL-2008, entry version 78.
DE   Promotilin precursor [Contains: Motilin; Motilin-associated peptide
DE   (MAP)].
GN   Name=MLN;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=88030048; PubMed=3666144; DOI=10.1016/0014-5793(87)80512-4;
RA   Seino Y., Tanaka K., Takeda J., Takahashi H., Mitani T., Kurono M.,
RA   Kayano T., Koh G., Fukumoto H., Yano H., Fujita J., Inagaki N.,
RA   Yamada Y., Imura H.;
RT   "Sequence of an intestinal cDNA encoding human motilin precursor.";
RL   FEBS Lett. 223:74-76(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=89289989; PubMed=2737284; DOI=10.1016/0014-5793(89)80633-7;
RA   Yano H., Seino Y., Fujita J., Yamada Y., Inagaki N., Takeda J.,
RA   Bell G.I., Eddy R.L., Fan Y.-S., Byers M.G., Shows T.B., Imura H.;
RT   "Exon-intron organization, expression, and chromosomal localization of
RT   the human motilin gene.";
RL   FEBS Lett. 249:248-252(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=90091748; PubMed=2574660;
RA   Daikh D.I., Douglass J.O., Adelman J.P.;
RT   "Structure and expression of the human motilin gene.";
RL   DNA 8:615-621(1989).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=89121385; PubMed=2914635;
RA   Dea D., Boileau G., Poitras P., Lahaie R.G.;
RT   "Molecular heterogeneity of human motilin-like immunoreactivity
RT   explained by the processing of prepromotilin.";
RL   Gastroenterology 96:695-703(1989).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-15.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PROTEIN SEQUENCE OF 26-40.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Plays an important role in the regulation of
CC       interdigestive gastrointestinal motility and indirectly causes
CC       rhythmic contraction of duodenal and colonic smooth muscle.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the motilin family.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Motilin entry;
CC       URL="http://en.wikipedia.org/wiki/Motilin";
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DR   EMBL; Y00695; CAA68690.1; -; mRNA.
DR   EMBL; X15393; CAA33448.1; -; Genomic_DNA.
DR   EMBL; X15396; CAA33448.1; JOINED; Genomic_DNA.
DR   EMBL; X15395; CAA33448.1; JOINED; Genomic_DNA.
DR   EMBL; X15394; CAA33448.1; JOINED; Genomic_DNA.
DR   EMBL; M30281; AAA59860.1; -; Genomic_DNA.
DR   EMBL; M30278; AAA59860.1; JOINED; Genomic_DNA.
DR   EMBL; M30279; AAA59860.1; JOINED; Genomic_DNA.
DR   EMBL; M30280; AAA59860.1; JOINED; Genomic_DNA.
DR   EMBL; BC069675; AAH69675.1; -; mRNA.
DR   PIR; A33323; A33323.
DR   RefSeq; NP_001035198.1; -.
DR   RefSeq; NP_002409.1; -.
DR   UniGene; Hs.2813; -.
DR   PDB; 1LBJ; NMR; -; A=26-47.
DR   PDBsum; 1LBJ; -.
DR   Ensembl; ENSG00000096395; Homo sapiens.
DR   GeneID; 4295; -.
DR   KEGG; hsa:4295; -.
DR   H-InvDB; HIX0032938; -.
DR   HGNC; HGNC:7141; MLN.
DR   MIM; 158270; gene.
DR   PharmGKB; PA30402; -.
DR   HOGENOM; P12872; -.
DR   HOVERGEN; P12872; -.
DR   ArrayExpress; P12872; -.
DR   CleanEx; HS_MLN; -.
DR   GermOnline; ENSG00000096395; Homo sapiens.
DR   GO; GO:0005625; C:soluble fraction; TAS:ProtInc.
DR   GO; GO:0005102; F:receptor binding; TAS:ProtInc.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signalin...; TAS:ProtInc.
DR   InterPro; IPR015662; Motilin.
DR   InterPro; IPR006737; Motilin_assoc.
DR   InterPro; IPR006738; Motilin_ghrelin.
DR   PANTHER; PTHR14156; Motilin; 1.
DR   Pfam; PF04643; Motilin_assoc; 1.
DR   Pfam; PF04644; Motilin_ghrelin; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Hormone; Polymorphism; Secreted; Signal.
FT   SIGNAL        1     25
FT   CHAIN        26    115       Promotilin.
FT                                /FTId=PRO_0000342171.
FT   PEPTIDE      26     47       Motilin.
FT                                /FTId=PRO_0000019184.
FT   PEPTIDE      50    115       Motilin-associated peptide.
FT                                /FTId=PRO_0000019185.
FT   VARIANT      15     15       V -> A (in dbSNP:rs2281820).
FT                                /FTId=VAR_020372.
FT   HELIX        32     46
SQ   SEQUENCE   115 AA;  12920 MW;  30D4BB59B2F42783 CRC64;
     MVSRKAVAAL LVVHVAAMLA SQTEAFVPIF TYGELQRMQE KERNKGQKKS LSVWQRSGEE
     GPVDPAEPIR EEENEMIKLT APLEIGMRMN SRQLEKYPAT LEGLLSEMLP QHAAK
//