Allatostatin-1
     (AST1)
Allatostatin-2
     (AST2)
     (ASB2)
     (ASA5)
Allatostatin-3
     (AST3)
Allatostatin-4
     (AST4)
     (ASA7)
Allatostatin-5
     (AST5)
     (ASA4)
Allatostatin-6
     (AST6)
Allatostatin-7
     (AST7)
     (ASA1)
Allatostatin-8
     (AST8)
     (ASA3)
Allatostatin-9
     (AST9)
     (ASA2)
Allatostatin-10
     (AST10)
Allatostatin-11
     (AST11)
     (ASA6)
Allatostatin-12
     (AST12)
Allatostatin-13
     (AST13)

Gene name

None

From

Diploptera punctata (Pacific beetle cockroach)

[TaxID: 6984]

Taxonomy

Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Orthopteroidea; Dictyoptera; Blattaria; Blaberidae; Diplopterinae; Diploptera.

Protein existence

1: Evidence at protein level;

References

[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Brain; DOI=10.1073/pnas.90.19.8807; PubMed=8415611 [NCBI, ExPASy, EBI, Israel, Japan] Donly B.C., Ding Q., Tobe S.S., Bendena W.G.; "Molecular cloning of the gene for the allatostatin family of neuropeptides from the cockroach Diploptera punctata."; Proc. Natl. Acad. Sci. U.S.A. 90:8807-8811(1993).
[2]	PROTEIN SEQUENCE OF 154-161; 176-188; 192-200 AND 204-213. TISSUE=Brain; DOI=10.1073/pnas.86.15.5997; PubMed=2762309 [NCBI, ExPASy, EBI, Israel, Japan] Woodhead A.P., Stay B., Seidel S.L., Khan M.A., Tobe S.S.; "Primary structure of four allatostatins: neuropeptide inhibitors of juvenile hormone synthesis."; Proc. Natl. Acad. Sci. U.S.A. 86:5997-6001(1989).
[3]	PROTEIN SEQUENCE OF 77-94. TISSUE=Brain; DOI=10.1073/pnas.88.6.2412; PubMed=2006179 [NCBI, ExPASy, EBI, Israel, Japan] Pratt G.E., Farnsworth D.E., Fok K.F., Siegel N.R., McCormack A.L., Shabanowitz J., Hunt D.F., Feyereisen R.; "Identity of a second type of allatostatin from cockroach brains: an octadecapeptide amide with a tyrosine-rich address sequence."; Proc. Natl. Acad. Sci. U.S.A. 88:2412-2416(1991).
[4]	NUCLEOTIDE SEQUENCE [MRNA] OF 77-189. DOI=10.1073/pnas.91.25.11894; PubMed=7991553 [NCBI, ExPASy, EBI, Israel, Japan] Reichwald K., Unnithan G.C., Davis N.T., Agricola H., Feyereisen R.; "Expression of the allatostatin gene in endocrine cells of the cockroach midgut."; Proc. Natl. Acad. Sci. U.S.A. 91:11894-11898(1994).
[5]	PROTEIN SEQUENCE OF 176-188 (AST7). TISSUE=Brain; DOI=10.1016/0006-291X(89)91111-X; PubMed=2783135 [NCBI, ExPASy, EBI, Israel, Japan] Pratt G.E., Farnsworth D.E., Siegel N.R., Fok K.F., Feyereisen R.; "Identification of an allatostatin from adult Diploptera punctata."; Biochem. Biophys. Res. Commun. 163:1243-1247(1989).

Comments

FUNCTION: Neuropeptide inhibitors of juvenile hormone synthesis.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Brain, suboesophageal ganglion and corpus allatum.
SIMILARITY: Belongs to the allatostatin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U00444; AAA18260.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
S74578; AAB32720.2; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A48252; A48252.

3D structure databases

PDB

2JQS; NMR; -; A=154-161.	[ExPASy / RCSB / EBI]
2JQU; NMR; -; A=192-200.	[ExPASy / RCSB / EBI]

Detailed list of linked structures.

PDBsum

2JQS; -.
2JQU; -.

ModBase

P12764.

Ontologies

GO:0005576;	Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005184;	Molecular function: neuropeptide hormone activity (inferred from electronic annotation from InterPro).
GO:0007218;	Biological process: neuropeptide signaling pathway (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR010276; Allatostatin.
Graphical view of domain structure.

Pfam

PF05953; Allatostatin; 14.
Pfam graphical view of domain structure.

Other

ProtoNet

P12764.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Amidation; Cleavage on pair of basic residues; Direct protein sequencing; Neuropeptide; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 27`	`27`	`Potential.`
`PROPEP`	`28 65`	`38`		`PRO_0000001129`
`PEPTIDE`	`68 73`	`6`	`Allatostatin-1.`	`PRO_0000001130`
`PEPTIDE`	`77 94`	`18`	`Allatostatin-2.`	`PRO_0000001131`
`PEPTIDE`	`98 105`	`8`	`Allatostatin-3.`	`PRO_0000001132`
`PEPTIDE`	`109 117`	`9`	`Allatostatin-4.`	`PRO_0000001133`
`PROPEP`	`121 151`	`31`		`PRO_0000001134`
`PEPTIDE`	`154 161`	`8`	`Allatostatin-5.`	`PRO_0000001135`
`PEPTIDE`	`165 172`	`8`	`Allatostatin-6.`	`PRO_0000001136`
`PEPTIDE`	`176 188`	`13`	`Allatostatin-7.`	`PRO_0000001137`
`PEPTIDE`	`192 200`	`9`	`Allatostatin-8.`	`PRO_0000001138`
`PEPTIDE`	`204 213`	`10`	`Allatostatin-9.`	`PRO_0000001139`
`PEPTIDE`	`217 232`	`16`	`Allatostatin-10.`	`PRO_0000001140`
`PROPEP`	`236 251`	`16`		`PRO_0000001141`
`PEPTIDE`	`254 264`	`11`	`Allatostatin-11.`	`PRO_0000001142`
`PROPEP`	`268 345`	`78`		`PRO_0000001143`
`PEPTIDE`	`348 353`	`6`	`Allatostatin-12.`	`PRO_0000001144`
`PEPTIDE`	`357 364`	`8`	`Allatostatin-13.`	`PRO_0000001145`
`PROPEP`	`368 370`	`3`		`PRO_0000001146`
`MOD_RES`	`73 73`		`Leucine amide.`
`MOD_RES`	`94 94`		`Leucine amide.`
`MOD_RES`	`105 105`		`Leucine amide.`
`MOD_RES`	`117 117`		`Leucine amide.`
`MOD_RES`	`161 161`		`Leucine amide.`
`MOD_RES`	`172 172`		`Leucine amide.`
`MOD_RES`	`188 188`		`Leucine amide.`
`MOD_RES`	`200 200`		`Leucine amide.`
`MOD_RES`	`213 213`		`Leucine amide.`
`MOD_RES`	`232 232`		`Leucine amide.`
`MOD_RES`	`264 264`		`Leucine amide.`
`MOD_RES`	`353 353`		`Leucine amide.`
`MOD_RES`	`364 364`		`Isoleucine amide.`
`HELIX`	`157 159`	`3`
`STRAND`	`194 198`	`5`

Sequence information

Length: 370 AA [This is the length of the unprocessed precursor]

Molecular weight: 41562 Da [This is the MW of the unprocessed precursor]

CRC64: A5AA8E7C13DE8ED9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSGPRTCFCL PSALVLVLLS LSTSALGTAP EPSGVHEESP AGGGTDLLPH PEDLSASDNP 

        70         80         90        100        110        120 
DLEFVKRLYD FGLGKRAYSY VSEYKRLPVY NFGLGKRSKM YGFGLGKRDG RMYSFGLGKR 

       130        140        150        160        170        180 
DYDYYGEEDE DDQQAIGDED IEESDVGDLM DKRDRLYSFG LGKRARPYSF GLGKRAPSGA 

       190        200        210        220        230        240 
QRLYGFGLGK RGGSLYSFGL GKRGDGRLYA FGLGKRPVNS GRSSGSRFNF GLGKRSDDID 

       250        260        270        280        290        300 
FRELEEKFAE DKRYPQEHRF SFGLGKREVE PSELEAVRNE EKDNSSVHDK KNNTNDMHSG 

       310        320        330        340        350        360 
ERIKRSLHYP FGIRKLESSY DLNSASSLNS EENDDITPEE FSRMVRRPFN FGLGKRIPMY 

       370 
DFGIGKRSER

P12764 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools