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- FUNCTION: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation; in ovulation it weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4.
- CATALYTIC ACTIVITY: Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.
- ENZYME REGULATION: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin. Activated with catalytic amounts of streptokinase.
- SUBUNIT: Interacts with CSPG4 (By similarity).
- SUBCELLULAR LOCATION: Secreted.
- DOMAIN: Kringle domains mediate interaction with CSPG4 (By similarity).
- PTM: In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide (By similarity).
- MISCELLANEOUS: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot.
- MISCELLANEOUS: In the presence of the inhibitor, the activation involves only cleavage after Arg-580, resulting in 2 chains held together by 2 disulfide bonds. Without the inhibitor, the activation involves also removal of the activation peptide.
- SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily [view classification].
- SIMILARITY: Contains 5 kringle domains.
- SIMILARITY: Contains 1 PAN domain.
- SIMILARITY: Contains 1 peptidase S1 domain [view classification].
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 810 AA [This is the length of the unprocessed precursor] |
Molecular weight: 90255 Da [This is the MW of the unprocessed precursor] |
CRC64: A75E1C51A1A0F24A [This is a checksum on the sequence] |
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10 20 30 40 50 60
MEHKEVVLLL LLFLKSGQGE PLDDYVNTKG ASLFSITKKQ LGAGSIEECA AKCEEEEEFT
70 80 90 100 110 120
CRSFQYHSKE QQCVIMAENR KSSIVFRMRD VVLFEKKVYL SECKTGNGKN YRGTMSKTRT
130 140 150 160 170 180
GITCQKWSST SPHRPTFSPA THPSEGLEEN YCRNPDNDGQ GPWCYTTDPE ERFDYCDIPE
190 200 210 220 230 240
CEDECMHCSG ENYDGKISKT MSGLECQAWD SQSPHAHGYI PSKFPNKNLK KNYCRNPDGE
250 260 270 280 290 300
PRPWCFTTDP NKRWELCDIP RCTTPPPSSG PTYQCLKGTG ENYRGDVAVT VSGHTCHGWS
310 320 330 340 350 360
AQTPHTHNRT PENFPCKNLD ENYCRNPDGE KAPWCYTTNS QVRWEYCKIP SCESSPVSTE
370 380 390 400 410 420
PLDPTAPPEL TPVVQECYHG DGQSYRGTSS TTTTGKKCQS WSSMTPHWHE KTPENFPNAG
430 440 450 460 470 480
LTMNYCRNPD ADKGPWCFTT DPSVRWEYCN LKKCSGTEGS VAAPPPVAQL PDAETPSEED
490 500 510 520 530 540
CMFGNGKGYR GKKATTVTGT PCQEWAAQEP HSHRIFTPET NPRAGLEKNY CRNPDGDVGG
550 560 570 580 590 600
PWCYTTNPRK LFDYCDVPQC AASSFDCGKP QVEPKKCPGR VVGGCVAYPH SWPWQISLRT
610 620 630 640 650 660
RLGMHFCGGT LISPEWVLTA AHCLEKSSRP SFYKVILGAH REVHLEPHVQ EIEVSKMFSE
670 680 690 700 710 720
PARADIALLK LSSPAIITDK VIPACLPSPN YVVADRTECF ITGWGETQGT YGAGLLKEAR
730 740 750 760 770 780
LPVIENKVCN RYEFLNGTVK TTELCAGHLA GGTDSCQGDS GGPLVCFEKD KYILQGVTSW
790 800 810
GLGCARPNKP GVYVRVSRFV TWIEGVMRNN
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P12545 in FASTA format |
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ExPASy Home page
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