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UniProtKB/Swiss-Prot entry P12263

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FA8_PIG
Primary accession number P12263
Secondary accession number Q95243
Integrated into Swiss-Prot on October 1, 1989
Sequence was last modified on November 1, 1997 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 71)
Name and origin of the protein
Protein name Coagulation factor VIII [Precursor]
Synonym Procoagulant component
Gene name
Name: F8
Synonyms: CF8
From
Sus scrofa (Pig) [TaxID: 9823] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
Healey J.F., Lubin I.M., Lollar P.;
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [MRNA] OF 705-1573.
PubMed=3016730 [NCBI, ExPASy, EBI, Israel, Japan]
Toole J.J., Pittman D.D., Orr E.C., Murtha P., Wasley L.C., Kaufman R.J.;
"A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for in vitro procoagulant activity.";
Proc. Natl. Acad. Sci. U.S.A. 83:5939-5942(1986).
[3]
 NUCLEOTIDE SEQUENCE [MRNA] OF 392-759.
PubMed=7510693 [NCBI, ExPASy, EBI, Israel, Japan]
Lubin I.M., Healey J.F., Scandella D., Runge M.S., Lollar P.;
"Elimination of a major inhibitor epitope in factor VIII.";
J. Biol. Chem. 269:8639-8641(1994).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U49517; AAB06705.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A25945; A25945.
T42763; T42763.
RefSeq NP_999332.1; -.
UniGene Ssc.16043
3D structure databases
HSSP P00451; 1D7P. [HSSP ENTRY / PDB]
ModBase P12263.
Family and domain databases
InterPro IPR000421; Coagulation_factor_5/8-type_C.
IPR001117; Cu-oxidase.
IPR011706; Cu-oxidase_2.
IPR011707; Cu-oxidase_3.
IPR002355; Cu_oxidase_Cu_BS.
IPR008972; Cupredoxin.
IPR014707; Factor_VIII.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.420; Cupredoxin; 6.
PANTHER PTHR10127:SF50; Factor_VIII; 1.
Pfam PF00394; Cu-oxidase; 1.
PF07731; Cu-oxidase_2; 1.
PF07732; Cu-oxidase_3; 1.
PF00754; F5_F8_type_C; 2.
Pfam graphical view of domain structure.
SMART SM00231; FA58C; 2.
SMART graphical view of domain structure.
PROSITE PS01285; FA58C_1; 2.
PS01286; FA58C_2; 2.
PS50022; FA58C_3; 2.
PS00079; MULTICOPPER_OXIDASE1; 3.
PROSITE graphical view of domain structure (profiles).
BLOCKS P12263.
Genome annotation databases
GeneID 397339; -.
KEGG ssc:397339; -.
Phylogenomic databases
HOVERGEN P12263; -.
Other
LinkHub P12263; -.
ProtoNet P12263.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acute phase; Blood coagulation; Calcium; Glycoprotein; Metal-binding; Repeat; Secreted; Signal; Sulfation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     19  19     Potential. 
CHAIN   20   2133  2114     Coagulation factor VIII. PRO_0000002973
DOMAIN   20    357  338     F5/8 type A 1. 
DOMAIN   20    199  180     Plastocyanin-like 1. 
DOMAIN   207    357  151     Plastocyanin-like 2. 
DOMAIN   399    730  332     F5/8 type A 2. 
DOMAIN   399    573  175     Plastocyanin-like 3. 
DOMAIN   583    730  148     Plastocyanin-like 4. 
DOMAIN   1495   1822  328     F5/8 type A 3. 
DOMAIN   1495   1659  165     Plastocyanin-like 5. 
DOMAIN   1669   1822  154     Plastocyanin-like 6. 
DOMAIN   1822   1970  149     F5/8 type C 1. 
DOMAIN   1975   2127  153     F5/8 type C 2. 
REGION   760   1599  840     B. 
SITE   391    392  2     Cleavage; by thrombin (By similarity). 
SITE   759    760  2     Cleavage; by thrombin (By similarity). 
SITE   1449   1450  2     Cleavage (activation) (By similarity). 
SITE   1490   1491  2     Cleavage; by thrombin (By similarity). 
MOD_RES   737    737        Sulfotyrosine (By similarity). 
MOD_RES   738    738        Sulfotyrosine (By similarity). 
MOD_RES   742    742        Sulfotyrosine (By similarity). 
CARBOHYD   233    233        N-linked (GlcNAc...) (Potential). 
CARBOHYD   259    259        N-linked (GlcNAc...) (Potential). 
CARBOHYD   601    601        N-linked (GlcNAc...) (Potential). 
CARBOHYD   929    929        N-linked (GlcNAc...) (Potential). 
CARBOHYD   985    985        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1025   1025        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1111   1111        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1181   1181        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1208   1208        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1245   1245        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1265   1265        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1335   1335        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1408   1408        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1611   1611        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1919   1919        N-linked (GlcNAc...) (Potential). 
DISULFID   173    199        Probable. 
DISULFID   547    573        Probable. 
DISULFID   1633   1659        Probable. 
DISULFID   1822   1970        By similarity. 
DISULFID   1975   2127        By similarity. 
CONFLICT   713    713        N -> M (in Ref. 2). 
CONFLICT   734    734        I -> T (in Ref. 2). 
CONFLICT   792    792        G -> Q (in Ref. 2). 
CONFLICT   1133   1133        E -> F (in Ref. 2). 
CONFLICT   1191   1191        I -> L (in Ref. 2). 
CONFLICT   1209   1209        R -> F (in Ref. 2). 
CONFLICT   1437   1437        C -> G (in Ref. 2). 
CONFLICT   1456   1456        F -> R (in Ref. 2). 
CONFLICT   1539   1539        F -> R (in Ref. 2). 
CONFLICT   1546   1546        Q -> N (in Ref. 2). 
Sequence information
Length: 2133 AA [This is the length of the unprocessed precursor] Molecular weight: 239305 Da [This is the MW of the unprocessed precursor] CRC64: 152BBA8997F570DA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQLELSTCVF LCLLPLGFSA IRRYYLGAVE LSWDYRQSEL LRELHVDTRF PATAPGALPL 

        70         80         90        100        110        120 
GPSVLYKKTV FVEFTDQLFS VARPRPPWMG LLGPTIQAEV YDTVVVTLKN MASHPVSLHA 

       130        140        150        160        170        180 
VGVSFWKSSE GAEYEDHTSQ REKEDDKVLP GKSQTYVWQV LKENGPTASD PPCLTYSYLS 

       190        200        210        220        230        240 
HVDLVKDLNS GLIGALLVCR EGSLTRERTQ NLHEFVLLFA VFDEGKSWHS ARNDSWTRAM 

       250        260        270        280        290        300 
DPAPARAQPA MHTVNGYVNR SLPGLIGCHK KSVYWHVIGM GTSPEVHSIF LEGHTFLVRH 

       310        320        330        340        350        360 
HRQASLEISP LTFLTAQTFL MDLGQFLLFC HISSHHHGGM EAHVRVESCA EEPQLRRKAD 

       370        380        390        400        410        420 
EEEDYDDNLY DSDMDVVRLD GDDVSPFIQI RSVAKKHPKT WVHYISAEEE DWDYAPAVPS 

       430        440        450        460        470        480 
PSDRSYKSLY LNSGPQRIGR KYKKARFVAY TDVTFKTRKA IPYESGILGP LLYGEVGDTL 

       490        500        510        520        530        540 
LIIFKNKASR PYNIYPHGIT DVSALHPGRL LKGWKHLKDM PILPGETFKY KWTVTVEDGP 

       550        560        570        580        590        600 
TKSDPRCLTR YYSSSINLEK DLASGLIGPL LICYKESVDQ RGNQMMSDKR NVILFSVFDE 

       610        620        630        640        650        660 
NQSWYLAENI QRFLPNPDGL QPQDPEFQAS NIMHSINGYV FDSLQLSVCL HEVAYWYILS 

       670        680        690        700        710        720 
VGAQTDFLSV FFSGYTFKHK MVYEDTLTLF PFSGETVFMS MENPGLWVLG CHNSDLRNRG 

       730        740        750        760        770        780 
MTALLKVYSC DRDIGDYYDN TYEDIPGFLL SGKNVIEPRS FAQNSRPPSA SQKQFQTITS 

       790        800        810        820        830        840 
PEDDVELDPQ SGERTQALEE LSVPSGDGSM LLGQNPAPHG SSSSDLQEAR NEADDYLPGA 

       850        860        870        880        890        900 
RERNTAPSAA ARLRPELHHS AERVLTPEPE KELKKLDSKM SSSSDLLKTS PTIPSDTLSA 

       910        920        930        940        950        960 
ETERTHSLGP PHPQVNFRSQ LGAIVLGKNS SHFIGAGVPL GSTEEDHESS LGENVSPVES 

       970        980        990       1000       1010       1020 
DGIFEKERAH GPASLTKDDV LFKVNISLVK TNKARVYLKT NRKIHIDDAA LLTENRASAT 

      1030       1040       1050       1060       1070       1080 
FMDKNTTASG LNHVSNWIKG PLGKNPLSSE RGPSPELLTS SGSGKSVKGQ SSGQGRIRVA 

      1090       1100       1110       1120       1130       1140 
VEEEELSKGK EMMLPNSELT FLTNSADVQG NDTHSQGKKS REEMERREKL VQEKVDLPQV 

      1150       1160       1170       1180       1190       1200 
YTATGTKNFL RNIFHQSTEP SVEGFDGGSH APVPQDSRSL NDSAERAETH IAHFSAIREE 

      1210       1220       1230       1240       1250       1260 
APLEAPGNRT GPGPRSAVPR RVKQSLKQIR LPLEEIKPER GVVLNATSTR WSESSPILQG 

      1270       1280       1290       1300       1310       1320 
AKRNNLSLPF LTLEMAGGQG KISALGKSAA GPLASGKLEK AVLSSAGLSE ASGKAEFLPK 

      1330       1340       1350       1360       1370       1380 
VRVHREDLLP QKTSNVSCAH GDLGQEIFLQ KTRGPVNLNK VNRPGRTPSK LLGPPMPKEW 

      1390       1400       1410       1420       1430       1440 
ESLEKSPKST ALRTKDIISL PLDRHESNHS IAAKNEGQAE TQREAAWTKQ GGPGRLCAPK 

      1450       1460       1470       1480       1490       1500 
PPVLRRHQRD ISLPTFQPEE DKMDYDDIFS TETKGEDFDI YGEDENQDPR SFQKRTRHYF 

      1510       1520       1530       1540       1550       1560 
IAAVEQLWDY GMSESPRALR NRAQNGEVPR FKKVVFREFA DGSFTQPSYR GELNKHLGLL 

      1570       1580       1590       1600       1610       1620 
GPYIRAEVED NIMVTFKNQA SRPYSFYSSL ISYPDDQEQG AEPRHNFVQP NETRTYFWKV 

      1630       1640       1650       1660       1670       1680 
QHHMAPTEDE FDCKAWAYFS DVDLEKDVHS GLIGPLLICR ANTLNAAHGR QVTVQEFALF 

      1690       1700       1710       1720       1730       1740 
FTIFDETKSW YFTENVERNC RAPCHLQMED PTLKENYRFH AINGYVMDTL PGLVMAQNQR 

      1750       1760       1770       1780       1790       1800 
IRWYLLSMGS NENIHSIHFS GHVFSVRKKE EYKMAVYNLY PGVFETVEML PSKVGIWRIE 

      1810       1820       1830       1840       1850       1860 
CLIGEHLQAG MSTTFLVYSK ECQAPLGMAS GRIRDFQITA SGQYGQWAPK LARLHYSGSI 

      1870       1880       1890       1900       1910       1920 
NAWSTKDPHS WIKVDLLAPM IIHGIMTQGA RQKFSSLYIS QFIIMYSLDG RNWQSYRGNS 

      1930       1940       1950       1960       1970       1980 
TGTLMVFFGN VDASGIKHNI FNPPIVARYI RLHPTHYSIR STLRMELMGC DLNSCSMPLG 

      1990       2000       2010       2020       2030       2040 
MQNKAISDSQ ITASSHLSNI FATWSPSQAR LHLQGRTNAW RPRVSSAEEW LQVDLQKTVK 

      2050       2060       2070       2080       2090       2100 
VTGITTQGVK SLLSSMYVKE FLVSSSQDGR RWTLFLQDGH TKVFQGNQDS STPVVNALDP 

      2110       2120       2130 
PLFTRYLRIH PTSWAQHIAL RLEVLGCEAQ DLY
P12263 in FASTA format

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