PROTEIN SEQUENCE.
DOI=10.1016/0006-291X(74)90919-X; PubMed=4831071 [NCBI, ExPASy, EBI, Israel, Japan]
Nakamura S., Iwanaga S., Suzuki T., Mikuni Y., Konishi K.;
"Amino acid sequence of the peptide released from bovine factor XIII following activation by thrombin.";
Biochem. Biophys. Res. Commun. 58:250-256(1974).

Comments

FUNCTION: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
CATALYTIC ACTIVITY: Protein glutamine + alkylamine = protein N⁵-alkylglutamine + NH₃.
COFACTOR: Binds 1 calcium ion per subunit (By similarity).
SUBUNIT: Tetramer of two A chains and two B chains.
SUBCELLULAR LOCATION: Cytoplasm. Secreted. Note=Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
PTM: The activation peptide is released by thrombin.
SIMILARITY: Belongs to the transglutaminase superfamily. Transglutaminase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

PIR

A10933; A10933.

3D structure databases

HSSP

P00488; 1GGY. [HSSP ENTRY / SWISS-3DIMAGE / PDB]

ModBase

P12260.

Ontologies

GO:0003810;	Molecular function: protein-glutamine gamma-glutamyltransferase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR013808; Transglutaminase_CS.
Graphical view of domain structure.

PROSITE

PS00547; TRANSGLUTAMINASES; PARTIAL.

BLOCKS

P12260.

Genome annotation databases

Ensembl

ENSBTAG00000007268; Bos taurus. [Contig view]

Phylogenomic databases

HOVERGEN

P12260; -.

Other

ProtoNet

P12260.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; Acyltransferase; Blood coagulation; Calcium; Cytoplasm; Direct protein sequencing; Secreted; Transferase; Zymogen.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`PROPEP`	`1 37`	`37`	`Activation peptide.`	`PRO_0000033645`
`MOD_RES`	`1 1`		`N-acetylserine (By similarity).`
`NON_TER`	`37 37`

Sequence information

Length: 37 AA [This is the length of the partial sequence]

Molecular weight: 3795 Da [This is the MW of the partial sequence]

CRC64: 95700493889638CB [This is a checksum on the sequence]

        10         20         30 
SESSGTAFGG RRAIPPNTSN AAEDDPPTVE LQGLVPR

P12260 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools