[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1016/0888-7543(90)90567-E; PubMed=2155175 [NCBI, ExPASy, EBI, Israel, Japan] Pittler S.J., Baehr W., Wasmuth J.J., McConnell D.G., Champagne M.S., VanTuinen P., Ledbetter D., Davis R.L.; "Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene."; Genomics 6:272-283(1990).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Retina; PubMed=2826095 [NCBI, ExPASy, EBI, Israel, Japan] Yu A., Ovchinnikov A., Gubanov V.V., Khramtsov N.V., Akhmedov N.B., Ishchenko K.A., Zagranichnyi V.E., Vasilevskaya I.A., Rakitina T.V., Atabekova N.V., Barinov A.A., Muradov K.G., Shuvaeva T.M., Bystrov N.S., Severtsova I.V., Lipkin V.M.; "Cyclic GMP phosphodiesterase from the bovine retina. Amino acid sequence of the alpha-subunit and nucleotide sequence of corresponding cDNA."; Dokl. Akad. Nauk SSSR 296:487-491(1987).
[3]	NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND ACETYLATION AT GLY-2. TISSUE=Retina; DOI=10.1016/0014-5793(87)80530-6; PubMed=2822478 [NCBI, ExPASy, EBI, Israel, Japan] Ovchinnikov Y.A., Gubanov V.V., Khramtsov N.V., Ischenko K.A., Zagranichny V.E., Muradov K.G., Shuvaeva T.M., Lipkin V.M.; "Cyclic GMP phosphodiesterase from bovine retina. Amino acid sequence of the alpha-subunit and nucleotide sequence of the corresponding cDNA."; FEBS Lett. 223:169-173(1987).

Comments

FUNCTION: This protein participates in processes of transmission and amplification of the visual signal.
CATALYTIC ACTIVITY: Guanosine 3',5'-cyclic phosphate + H₂O = guanosine 5'-phosphate.
SUBUNIT: Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential).
SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family.
SIMILARITY: Contains 2 GAF domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X12756; CAA31243.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M27541; AAA30441.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M36683; AAA30442.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M26043; AAA30443.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

S06418; S06418.

NP_001001526.2; -.

3D structure databases

HSSP

Q08499; 1OYN. [HSSP ENTRY / PDB]

ModBase

P11541.

Ontologies

GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0047555;	Molecular function: 3',5'-cyclic-GMP phosphodiesterase activity (inferred from electronic annotation from EC).
GO:0050896;	Biological process: response to stimulus (inferred from electronic annotation from UniProtKB-KW).
GO:0007165;	Biological process: signal transduction (inferred from electronic annotation from InterPro).
GO:0007601;	Biological process: visual perception (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR003018; GAF.
IPR003607; Met-dep_phosphohydro_HD.
IPR002073; PDEase.
Graphical view of domain structure.

Pfam

PF01590; GAF; 2.
PF00233; PDEase_I; 1.
Pfam graphical view of domain structure.

PRINTS

PR00387; PDIESTERASE1.

SMART

SM00065; GAF; 2.
SM00471; HDc; 1.
SMART graphical view of domain structure.

PROSITE

PS00126; PDEASE_I; 1.

Genome annotation databases

Ensembl

ENSBTAG00000012945; Bos taurus. [Contig view]

GeneID

281973; -.

KEGG

bta:281973; -.

Phylogenomic databases

HOVERGEN

P11541; -.

Other

ProtoNet

P11541.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; Cell membrane; cGMP; Direct protein sequencing; Hydrolase; Lipoprotein; Membrane; Prenylation; Repeat; Sensory transduction; Vision.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed.`
`CHAIN`	`2 859`	`858`	`Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha.`	`PRO_0000198826`
`DOMAIN`	`73 222`	`150`	`GAF 1.`
`DOMAIN`	`254 431`	`178`	`GAF 2.`
`MOD_RES`	`2 2`		`N-acetylglycine.`
`LIPID`	`856 856`		`S-farnesyl cysteine (By similarity).`
`VARIANT`	`381 381`	`1`	`M -> V.`
`CONFLICT`	`194 194`		`V -> A (in Ref. 2 and 3).`
`CONFLICT`	`424 424`		`T -> A (in Ref. 2 and 3).`
`CONFLICT`	`675 675`		`F -> C (in Ref. 2 and 3).`

Sequence information

Length: 859 AA [This is the length of the unprocessed precursor]

Molecular weight: 99341 Da [This is the MW of the unprocessed precursor]

CRC64: 701CB148F73A1303 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGEVTAEEVE KFLDSNVSFA KQYYNLRYRA KVISDLLGPR EAAVDFSNYH ALNSVEESEI 

        70         80         90        100        110        120 
IFDLLRDFQD NLQAEKCVFN VMKKLCFLLQ ADRMSLFMYR ARNGIAELAT RLFNVHKDAV 

       130        140        150        160        170        180 
LEECLVAPDS EIVFPLDMGV VGHVALSKKI VNVPNTEEDE HFCDFVDTLT EYQTKNILAS 

       190        200        210        220        230        240 
PIMNGKDVVA IIMVVNKVDG PHFTENDEEI LLKYLNFANL IMKVFHLSYL HNCETRRGQI 

       250        260        270        280        290        300 
LLWSGSKVFE ELTDIERQFH KALYTVRAFL NCDRYSVGLL DMTKQKEFFD VWPVLMGEAP 

       310        320        330        340        350        360 
PYAGPRTPDG REINFYKVID YILHGKEDIK VIPNPPPDHW ALVSGLPTYV AQNGLICNIM 

       370        380        390        400        410        420 
NAPSEDFFAF QKEPLDESGW MIKNVLSMPI VNKKEEIVGV ATFYNRKDGK PFDEMDETLM 

       430        440        450        460        470        480 
ESLTQFLGWS VLNPDTYELM NKLENRKDIF QDMVKYHVKC DNEEIQTILK TREVYGKEPW 

       490        500        510        520        530        540 
ECEEEELAEI LQGELPDADK YEINKFHFSD LPLTELELVK CGIQMYYELK VVDKFHIPQE 

       550        560        570        580        590        600 
ALVRFMYSLS KGYRRITYHN WRHGFNVGQT MFSLLVTGKL KRYFTDLEAL AMVTAAFCHD 

       610        620        630        640        650        660 
IDHRGTNNLY QMKSQNPLAK LHGSSILERH HLEFGKTLLR DESLNIFQNL NRRQHEHAIH 

       670        680        690        700        710        720 
MMDIAIIATD LALYFKKRTM FQKIVDQSKT YETQQEWTQY MMLDQTRKEI VMAMMMTACD 

       730        740        750        760        770        780 
LSAITKPWEV QSKVALLVAA EFWEQGDLER TVLQQNPIPM MDRNKADELP KLQVGFIDFV 

       790        800        810        820        830        840 
CTFVYKEFSR FHEEITPMLD GITNNRKEWK ALADEYETKM KGLEEEKQKQ QAANQAAAGS 

       850 
QHGGKQPGGG PASKSCCVQ

P11541 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools