[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Kidney;
DOI=10.1038/331091a0; PubMed=3267207 [NCBI, ExPASy, EBI, Israel, Japan]
Giguere V.,
Yang N.,
Segui P.,
Evans R.M.;
"Identification of a new class of steroid hormone receptors.";
Nature 331:91-94(1988).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Uterus;
DOI=10.1074/jbc.271.10.5795; PubMed=8621448 [NCBI, ExPASy, EBI, Israel, Japan]
Yang N.,
Shigeta H.,
Shi H.,
Teng C.T.;
"Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter.";
J. Biol. Chem. 271:5795-5804(1996).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04632; PubMed=16554811 [NCBI, ExPASy, EBI, Israel, Japan]
Taylor T.D.,
Noguchi H.,
Totoki Y.,
Toyoda A.,
Kuroki Y.,
Dewar K.,
Lloyd C.,
Itoh T.,
Takeda T.,
Kim D.-W.,
She X.,
Barlow K.F.,
Bloom T.,
Bruford E.,
Chang J.L.,
Cuomo C.A.,
Eichler E.,
FitzGerald M.G.,
Jaffe D.B., ![]()
LaButti K.,
Nicol R.,
Park H.-S.,
Seaman C.,
Sougnez C.,
Yang X.,
Zimmer A.R.,
Zody M.C.,
Birren B.W.,
Nusbaum C.,
Fujiyama A.,
Hattori M.,
Rogers J.,
Lander E.S.,
Sakaki Y.;
"Human chromosome 11 DNA sequence and analysis including novel gene identification.";
Nature 440:497-500(2006).
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[4]
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PROTEIN SEQUENCE OF 69-76.
PubMed=8224847 [NCBI, ExPASy, EBI, Israel, Japan]
Wiley S.R.,
Kraus R.J.,
Zuo F.,
Murray E.E.,
Loritz K.,
Mertz J.E.;
"SV40 early-to-late switch involves titration of cellular transcriptional repressors.";
Genes Dev. 7:2206-2219(1993).
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[5]
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FUNCTION.
PubMed=9271417 [NCBI, ExPASy, EBI, Israel, Japan]
Sladek R.,
Bader J.-A.,
Giguere V.;
"The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene.";
Mol. Cell. Biol. 17:5400-5409(1997).
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[6]
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INTERACTION WITH PPARGC1A, INDUCTION, AND FUNCTION.
DOI=10.1074/jbc.M212923200; PubMed=12522104 [NCBI, ExPASy, EBI, Israel, Japan]
Schreiber S.N.,
Knutti D.,
Brogli K.,
Uhlmann T.,
Kralli A.;
"The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).";
J. Biol. Chem. 278:9013-9018(2003).
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[7]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-27, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A.,
Jedrychowski M.,
Schwartz D.,
Elias J.E.,
Villen J.,
Li J.,
Cohn M.A.,
Cantley L.C.,
Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
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[8]
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DNA-BINDING SPECIFICITY, INTERACTION WITH PPARGC1A, HOMODIMERIZATION, FUNCTION, AND MUTAGENESIS OF SER-118 AND THR-124.
DOI=10.1210/me.2005-0313; PubMed=16150865 [NCBI, ExPASy, EBI, Israel, Japan]
Barry J.B.,
Laganiere J.,
Giguere V.;
"A single nucleotide in an estrogen-related receptor alpha site can dictate mode of binding and peroxisome proliferator-activated receptor gamma coactivator 1alpha activation of target promoters.";
Mol. Endocrinol. 20:302-310(2006).
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[9]
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SUMOYLATION AT LYS-14 AND LYS-403, PHOSPHORYLATION AT SER-19 AND SER-22, FUNCTION, AND MUTAGENESIS OF LYS-14; SER-19; SER-22; LYS-403; LEU-413 AND LEU-418.
DOI=10.1021/bi700316g; PubMed=17676930 [NCBI, ExPASy, EBI, Israel, Japan]
Vu E.H.,
Kraus R.J.,
Mertz J.E.;
"Phosphorylation-dependent sumoylation of estrogen-related receptor alpha1.";
Biochemistry 46:9795-9804(2007).
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[10]
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SUMOYLATION AT LYS-14 AND LYS-403, PHOSPHORYLATION AT SER-19 AND SER-22, INTERACTION WITH PIAS4, FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF LYS-14; SER-19; SER-22 AND LYS-403.
DOI=10.1210/me.2007-0357; PubMed=18063693 [NCBI, ExPASy, EBI, Israel, Japan]
Tremblay A.M.,
Wilson B.J.,
Yang X.-J.,
Giguere V.;
"Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif.";
Mol. Endocrinol. 22:570-584(2008).
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[11]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19 AND SER-22, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N.,
Zhou C.,
Villen J.,
Beausoleil S.A.,
Bakalarski C.E.,
Elledge S.J.,
Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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[12]
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X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 193-423 IN COMPLEX WITH THE L3 SITE-CONTAINING PEPTIDE OF COACTIVATOR PPARGC1A, HOMODIMERIZATION, AND MASS SPECTROMETRY.
DOI=10.1074/jbc.M407999200; PubMed=15337744 [NCBI, ExPASy, EBI, Israel, Japan]
Kallen J.,
Schlaeppi J.-M.,
Bitsch F.,
Filipuzzi I.,
Schilb A.,
Riou V.,
Graham A.,
Strauss A.,
Geiser M.,
Fournier B.;
"Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha.";
J. Biol. Chem. 279:49330-49337(2004).
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[13]
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X-RAY CRYSTALLOGRAPHY (2.11 ANGSTROMS) OF 180-423 IN COMPLEX WITH THE L3 SITE-CONTAINING PEPTIDE OF COACTIVATOR PPARGC1A, INTERACTION WITH PPARGC1A, AND MUTAGENESIS OF 258-MET--GLN-262; SER-259; ARG-315; ASP-338; HIS-341; GLU-343 AND 421-MET--ASP-423.
DOI=10.1074/jbc.M801920200; PubMed=18441008 [NCBI, ExPASy, EBI, Israel, Japan]
Greschik H.,
Althage M.,
Flaig R.,
Sato Y.,
Chavant V.,
Peluso-Iltis C.,
Choulier L.,
Cronet P.,
Rochel N.,
Schuele R.,
Stroemstedt P.E.,
Moras D.;
"Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop.";
J. Biol. Chem. 283:20220-20230(2008).
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