ID   COL_CHICK               Reviewed;          34 AA.
AC   P11148;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 2.
DT   22-JUL-2008, entry version 45.
DE   RecName: Full=Colipase;
DE   Flags: Fragment;
GN   Name=CLPS;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   MEDLINE=84281127; PubMed=6547861; DOI=10.1016/0300-9084(84)90025-7;
RA   Bosc-Bierne I., Rathelot J., Bechis G., Delori P., Sarda L.;
RT   "Evidence for the existence of procolipase in chicken pancreas and
RT   pancreatic juice.";
RL   Biochimie 66:413-416(1984).
RN   [2]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Pancreas;
RX   MEDLINE=81161117; PubMed=7213802; DOI=10.1016/0005-2795(81)90187-2;
RA   Bosc-Bierne I., Rathelot J., Canioni P., Julien R., Bechis G.,
RA   Gregorie J., Rochat H., Sarda L.;
RT   "Isolation and partial structural characterization of chicken
RT   pancreatic colipase.";
RL   Biochim. Biophys. Acta 667:225-232(1981).
CC   -!- FUNCTION: Colipase is a cofactor of pancreatic lipase. It allows
CC       the lipase to anchor itself to the lipid-water interface. Without
CC       colipase the enzyme is washed off by bile salts, which have an
CC       inhibitory effect on the lipase.
CC   -!- SUBUNIT: Forms a 1:1 stoichiometric complex with pancreatic
CC       lipase.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the pancreas.
CC   -!- SIMILARITY: Belongs to the colipase family.
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DR   PIR; A05330; A05330.
DR   UniGene; Gga.6607; -.
DR   HSSP; P02703; 1LPB.
DR   Ensembl; ENSGALG00000000900; Gallus gallus.
DR   HOGENOM; P11148; -.
DR   HOVERGEN; P11148; -.
DR   InterPro; IPR001981; Colipase.
DR   Pfam; PF01114; Colipase; 1.
DR   PROSITE; PS00121; COLIPASE_1; PARTIAL.
DR   PROSITE; PS51342; COLIPASE_2; 1.
PE   1: Evidence at protein level;
KW   Digestion; Direct protein sequencing; Lipid degradation; Secreted.
FT   CHAIN         1    >34       Colipase.
FT                                /FTId=PRO_0000144831.
FT   DISULFID     12     23       By similarity.
FT   DISULFID     18     34       By similarity.
FT   UNSURE       12     12
FT   NON_TER      34     34
SQ   SEQUENCE   34 AA;  3591 MW;  4A646B55FCB83BEB CRC64;
     GLIFNLDTGE LCLQSAQCKS ECCQEDSGLS LAXC
//