[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2840249 [NCBI, ExPASy, EBI, Israel, Japan]
Ting J.,
Lee A.S.;
"Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation.";
DNA 7:275-286(1988).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Cervix carcinoma;
Chao C.C.K.;
Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Fibroblast;
Hansen J.J.,
Nielsen M.N.,
Jorgensen M.M.,
Gregersen N.,
Bolund L.;
"Grp78 is involved in the quality control of the LDL-receptor.";
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [MRNA].
Bermudez-Fajardo A.,
Llewellyn D.H.,
Campbell A.K.,
Errington R.R.;
"Sequence differences between human grp78/BiP isolated from HeLa cells and previously reported human sequences.";
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT HIS-543.
NIEHS SNPs program;
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Muscle;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[7]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.
DOI=10.1093/nar/20.24.6481; PubMed=1480470 [NCBI, ExPASy, EBI, Israel, Japan]
Chao C.C.K.,
Lin-Chao S.;
"A direct-repeat sequence of the human BiP gene is required for A23187-mediated inducibility and an inducible nuclear factor binding.";
Nucleic Acids Res. 20:6481-6485(1992).
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[8]
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NUCLEOTIDE SEQUENCE [MRNA] OF 20-650, AND DISEASE.
TISSUE=Articular cartilage;
PubMed=11160188 [NCBI, ExPASy, EBI, Israel, Japan]
Corrigall V.M.,
Bodman-Smith M.D.,
Fife M.S.,
Canas B.,
Myers L.K.,
Wooley P.,
Soh C.,
Staines N.A.,
Pappin D.J.C.,
Berlo S.E.,
van Eden W.,
van Der Zee R.,
Lanchbury J.S.,
Panayi G.S.;
"The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis.";
J. Immunol. 166:1492-1498(2001).
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[9]
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PROTEIN SEQUENCE OF 22-38.
TISSUE=Mammary carcinoma;
DOI=10.1002/elps.1150180342; PubMed=9150946 [NCBI, ExPASy, EBI, Israel, Japan]
Rasmussen R.K.,
Ji H.,
Eddes J.S.,
Moritz R.L.,
Reid G.E.,
Simpson R.J.,
Dorow D.S.;
"Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.";
Electrophoresis 18:588-598(1997).
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[10]
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PROTEIN SEQUENCE OF 19-39, AND FUNCTION.
PubMed=2294010 [NCBI, ExPASy, EBI, Israel, Japan]
Dana R.C.,
Welch W.J.,
Deftos L.J.;
"Heat shock proteins bind calcitonin.";
Endocrinology 126:672-674(1990).
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[11]
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PROTEIN SEQUENCE OF 19-40.
TISSUE=Colon carcinoma;
DOI=10.1002/elps.1150180344; PubMed=9150948 [NCBI, ExPASy, EBI, Israel, Japan]
Ji H.,
Reid G.E.,
Moritz R.L.,
Eddes J.S.,
Burgess A.W.,
Simpson R.J.;
"A two-dimensional gel database of human colon carcinoma proteins.";
Electrophoresis 18:605-613(1997).
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[12]
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PROTEIN SEQUENCE OF 61-74; 82-96; 102-113; 124-152; 164-181; 186-214; 307-336; 353-367; 448-464; 475-492; 563-573; 602-617 AND 622-654, AND MASS SPECTROMETRY.
TISSUE=Brain, Cajal-Retzius cell, and Fetal brain cortex;
Lubec G.,
Vishwanath V.,
Chen W.-Q.,
Sun Y.;
Submitted (DEC-2008) to UniProtKB.
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[13]
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COMPONENT OF A CHAPERONE COMPLEX.
DOI=10.1091/mbc.E02-05-0311; PubMed=12475965 [NCBI, ExPASy, EBI, Israel, Japan]
Meunier L.,
Usherwood Y.-K.,
Chung K.T.,
Hendershot L.M.;
"A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.";
Mol. Biol. Cell 13:4456-4469(2002).
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[14]
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SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
DOI=10.1021/pr025562r; PubMed=12643545 [NCBI, ExPASy, EBI, Israel, Japan]
Basrur V.,
Yang F.,
Kushimoto T.,
Higashimoto Y.,
Yasumoto K.,
Valencia J.,
Muller J.,
Vieira W.D.,
Watabe H.,
Shabanowitz J.,
Hearing V.J.,
Hunt D.F.,
Appella E.;
"Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.";
J. Proteome Res. 2:69-79(2003).
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[15]
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SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
DOI=10.1021/pr060363j; PubMed=17081065 [NCBI, ExPASy, EBI, Israel, Japan]
Chi A.,
Valencia J.C.,
Hu Z.-Z.,
Watabe H.,
Yamaguchi H.,
Mangini N.J.,
Huang H.,
Canfield V.A.,
Cheng K.C.,
Yang F.,
Abe R.,
Yamagishi S.,
Shabanowitz J.,
Hearing V.J.,
Wu C.,
Appella E.,
Hunt D.F.;
"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.";
J. Proteome Res. 5:3135-3144(2006).
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[16]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-466, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0611217104; PubMed=17287340 [NCBI, ExPASy, EBI, Israel, Japan]
Molina H.,
Horn D.M.,
Tang N.,
Mathivanan S.,
Pandey A.;
"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.";
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
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[17]
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IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
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- FUNCTION: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.
- SUBUNIT: Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A.
- INTERACTION:
Q9NZJ5:EIF2AK3; NbExp=1; IntAct=EBI-354921, EBI-766076;
Q92597:NDRG1; NbExp=1; IntAct=EBI-354921, EBI-716486;
P60484:PTEN; NbExp=1; IntAct=EBI-354921, EBI-696162;
P04049:RAF1; NbExp=3; IntAct=EBI-354921, EBI-365996;
- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
- DISEASE: Autoantigen in rheumatoid arthritis [MIM:180300].
- SIMILARITY: Belongs to the heat shock protein 70 family.
- WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/hspa5/";.
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