|
|
|
|
|
|
[1]
|
NUCLEOTIDE SEQUENCE [MRNA] OF 1-745.
DOI=10.1093/nar/16.23.11075; PubMed=3060855 [NCBI, ExPASy, EBI, Israel, Japan]
Nomura N.,
Takahashi M.,
Matsui M.,
Ishii S.,
Date T.,
Sasamoto S.,
Ishizaki R.;
"Isolation of human cDNA clones of myb-related genes, A-myb and B-myb.";
Nucleic Acids Res. 16:11075-11089(1988).
|
[2]
|
NUCLEOTIDE SEQUENCE [MRNA] OF 398-752, AND CHARACTERIZATION.
PubMed=8058310 [NCBI, ExPASy, EBI, Israel, Japan]
Golay J.,
Loffarelli L.,
Luppi M.,
Castellano M.,
Introna M.;
"The human A-myb protein is a strong activator of transcription.";
Oncogene 9:2469-2479(1994).
|
[3]
|
NUCLEOTIDE SEQUENCE [MRNA] OF 727-752.
PubMed=7987850 [NCBI, ExPASy, EBI, Israel, Japan]
Ma X.P.,
Calabretta B.;
"DNA binding and transactivation activity of A-myb, a C-myb-related gene.";
Cancer Res. 54:6512-6516(1994).
|
[4]
|
IDENTIFICATION IN THE DREAM COMPLEX.
DOI=10.1016/j.molcel.2007.04.015; PubMed=17531812 [NCBI, ExPASy, EBI, Israel, Japan]
Litovchick L.,
Sadasivam S.,
Florens L.,
Zhu X.,
Swanson S.K.,
Velmurugan S.,
Chen R.,
Washburn M.P.,
Liu X.S.,
DeCaprio J.A.;
"Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.";
Mol. Cell 26:539-551(2007).
|
|
|
|
- FUNCTION: Strong transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Could have a role in the proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells.
- SUBUNIT: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.
- SUBCELLULAR LOCATION: Nucleus.
- TISSUE SPECIFICITY: Expressed in a variety of lymphoid and solid tumor lines cultured in vitro.
- SIMILARITY: Contains 3 HTH myb-type DNA-binding domains.
- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MYBL1ID41468ch8q13.html";.
|
|
|
|
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Length: 752 AA [This is the length of the unprocessed precursor] |
Molecular weight: 85887 Da [This is the MW of the unprocessed precursor] |
CRC64: 4C6D1823A7CAFCDA [This is a checksum on the sequence] |
|
10 20 30 40 50 60
MAKRSRSEDE DDDLQYADHD YEVPQQKGLK KLWNRVKWTR DEDDKLKKLV EQHGTDDWTL
70 80 90 100 110 120
IASHLQNRSD FQCQHRWQKV LNPELIKGPW TKEEDQRVIE LVQKYGPKRW SLIAKHLKGR
130 140 150 160 170 180
IGKQCRERWH NHLNPEVKKS SWTEEEDRII YEAHKRLGNR WAEIAKLLPG RTDNSIKNHW
190 200 210 220 230 240
NSTMRRKVEQ EGYLQDGIKS ERSSSKLQHK PCAAMDHMQT QNQFYIPVQI PGYQYVSPEG
250 260 270 280 290 300
NCIEHVQPTS AFIQQPFIDE DPDKEKKIKE LEMLLMSAEN EVRRKRIPSQ PGSFSSWSGS
310 320 330 340 350 360
FLMDDNMSNT LNSLDEHTSE FYSMDENQPV SAQQNSPTKF LAVEANAVLS SLQTIPEFAE
370 380 390 400 410 420
TLELIESDPV AWSDVTSFDI SDAAASPIKS TPVKLMRIQH NEGAMECQFN VSLVLEGKKN
430 440 450 460 470 480
TCNGGNSEAV PLTSPNIAKF STPPAILRKK RKMRVGHSPG SELRDGSLND GGNMALKHTP
490 500 510 520 530 540
LKTLPFSPSQ FFNTCPGNEQ LNIENPSFTS TPICGQKALI TTPLHKETTP KDQKENVGFR
550 560 570 580 590 600
TPTIRRSILG TTPRTPTPFK NALAAQEKKY GPLKIVSQPL AFLEEDIREV LKEETGTDLF
610 620 630 640 650 660
LKEEDEPAYK SCKQENTASG KKVRKSLVLD NWEKEESGTQ LLTEDISDMQ SENRFTTSLL
670 680 690 700 710 720
MIPLLEIHDN RCNLIPEKQD INSTNKTYTL TKKKPNPNTS KVVKLEKNLQ SNCEWETVVY
730 740 750
GKTEDQLIMT EQARRYLSTY TATSSTSRAL IL
|
P10243 in FASTA format |
|
ExPASy Home page
SIB Switzerland
