NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2839594 [NCBI, ExPASy, EBI, Israel, Japan]
McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.;
"The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1.";
J. Gen. Virol. 69:1531-1574(1988).

Comments

FUNCTION: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
CATALYTIC ACTIVITY: dUTP + H₂O = dUMP + diphosphate.
SIMILARITY: Belongs to the dUTPase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X14112; CAA32301.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

E30089; WMBEY0.

RefSeq

NP_044653.1; -.

3D structure databases

ModBase

P10234.

Ontologies

GO:0004170;	Molecular function: dUTP diphosphatase activity (inferred from electronic annotation from EC).
GO:0046080;	Biological process: dUTP metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR008180; DeoxyUTPase.
Graphical view of domain structure.

Pfam

PF00692; dUTPase; 1.
Pfam graphical view of domain structure.

Genome annotation databases

GeneID

2703421; -.

Other

ProtoNet

P10234.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Hydrolase; Nucleotide metabolism.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 371`	`371`		`Deoxyuridine 5'-triphosphate nucleotidohydrolase.`	`PRO_0000182952`

Sequence information

Length: 371 AA [This is the length of the unprocessed precursor]

Molecular weight: 39128 Da [This is the MW of the unprocessed precursor]

CRC64: 5FFA2556AD2F7158 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSQWGSGAIL VQPDSLGRGY DGDWHTAVAT RGGGVVQLNL VNRRAVAFMP KVSGDSGWAV 

        70         80         90        100        110        120 
GRVSLDLRMA MPADFCAIIH APALASPGHH VILGLIDSGY RGTVMAVVVA PKRTREFAPG 

       130        140        150        160        170        180 
TLRVDVTFLD ILATPPALTE PISLRQFPQL APPPPTGAGI REDPWLEGAL GAPSVTTALP 

       190        200        210        220        230        240 
ARRRGRSLVY AGELTPVQTE HGDGVREAIA FLPKREEDAG FDIVVRRPVT VPANGTTVVQ 

       250        260        270        280        290        300 
PSLRMLHADA GPAACYVLGR SSLNARGLLV VPTRWLPGHV CAFVVYNLTG VPVTLEAGAK 

       310        320        330        340        350        360 
VAQLLVAGAD ALPWIPPDNF HGTKALRNYP RGVPDSTAEP RNPPLLVFTN EFDAEAPPSE 

       370 
RGTGGFGSTG I

P10234 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools