[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=2839594 [NCBI, ExPASy, EBI, Israel, Japan] McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.; "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."; J. Gen. Virol. 69:1531-1574(1988).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=2826807 [NCBI, ExPASy, EBI, Israel, Japan] McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.; "Structures of herpes simplex virus type 1 genes required for replication of virus DNA."; J. Virol. 62:444-453(1988).

Comments

FUNCTION: Probably involved in DNA replication. Binds the origin of replication (ori).
SIMILARITY: Belongs to the herpesviridae OriBP family.
SIMILARITY: Contains 1 helicase ATP-binding domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X14112; CAA32345.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M19120; AAA45822.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

B29890; WMBEU9.

RefSeq

NP_044610.1; -.

3D structure databases

ModBase

P10193.

Protein-protein interaction databases

DIP

DIP:1095N; -.

Ontologies

GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from UniProtKB-KW).
GO:0003688;	Molecular function: DNA replication origin binding (inferred from electronic annotation from InterPro).
GO:0006260;	Biological process: DNA replication (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR014001; DEAD-like_N.
IPR014021; Helicase_SF1/SF2_ATP-bd.
IPR003450; Herpes_origin_bd.
Graphical view of domain structure.

Pfam

PF02399; Herpes_ori_bp; 1.
Pfam graphical view of domain structure.

SMART

SM00487; DEXDc; 1.
SMART graphical view of domain structure.

PROSITE

PS51192; HELICASE_ATP_BIND_1; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

GeneID

2703434; -.

Other

ProtoNet

P10193.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Complete proteome; DNA replication; DNA-binding; Nucleotide-binding.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 851`	`851`	`Replication origin-binding protein.`	`PRO_0000115866`
`DOMAIN`	`68 233`	`166`	`Helicase ATP-binding.`
`NP_BIND`	`81 88`	`8`	`ATP (Potential).`

Sequence information

Length: 851 AA [This is the length of the unprocessed precursor]

Molecular weight: 94262 Da [This is the MW of the unprocessed precursor]

CRC64: 961A133FE7A30CA7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPFVGGAESG DPLGAGRPIG DDECEQYTSS VSLARMLYGG DLAEWVPRVH PKTTIERQQH 

        70         80         90        100        110        120 
GPVTFPNASA PTARCVTVVR APMGSGKTTA LIRWLREAIH SPDTSVLVVS CRRSFTQTLA 

       130        140        150        160        170        180 
TRFAESGLVD FVTYFSSTNY IMNDRPFHRL IVQVESLHRV GPNLLNNYDV LVLDEVMSTL 

       190        200        210        220        230        240 
GQLYSPTMQQ LGRVDALMLR LLRICPRIIA MDATANAQLV DFLCGLRGEK NVHVVVGEYA 

       250        260        270        280        290        300 
MPGFSARRCL FLPRLGTELL QAALRPPGPP SGPSPDASPE ARGATFFGEL EARLGGGDNI 

       310        320        330        340        350        360 
CIFSSTVSFA EIVARFCRQF TDRVLLLHSL TPLGDVTTWG QYRVVIYTTV VTVGLSFDPL 

       370        380        390        400        410        420 
HFDGMFAYVK PMNYGPDMVS VYQSLGRVRT LRKGELLIYM DGSGARSEPV FTPMLLNHVV 

       430        440        450        460        470        480 
SSCGQWPAQF SQVTNLLCRR FKGRCDASAC DTSLGRGSRI YNKFRYKHYF ERCTLACLSD 

       490        500        510        520        530        540 
SLNILHMLLT LNCIRVRFWG HDDTLTPKDF CLFLRGVHFD ALRAQRDLRE LRCRDPEASL 

       550        560        570        580        590        600 
PAQAAETEEV GLFVEKYLRS DVAPAEIVAL MRNLNSLMGR TRFIYLALLE ACLRVPMATR 

       610        620        630        640        650        660 
SSAIFRRIYD HYATGVIPTI NVTGELELVA LPPTLNVTPV WELLCLCSTM AARLHWDSAA 

       670        680        690        700        710        720 
GGSGRTFGPD DVLDLLTPHY DRYMQLVFEL GHCNVTDGLL LSEEAVKRVA DALSGCPPRG 

       730        740        750        760        770        780 
SVSETDHAVA LFKIIWGELF GVQMAKSTQT FPGAGRVKNL TKQTIVGLLD AHHIDHSACR 

       790        800        810        820        830        840 
THRQLYALLM AHKREFAGAR FKLRVPAWGR CLRTHSSSAN PNADIILEAA LSELPTEAWP 

       850 
MMQGAVNFST L

P10193 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools