[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=2839594 [NCBI, ExPASy, EBI, Israel, Japan] McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.; "The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1."; J. Gen. Virol. 69:1531-1574(1988).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-80. PubMed=2826807 [NCBI, ExPASy, EBI, Israel, Japan] McGeoch D.J., Dalrymple M.A., Dolan A., McNab D., Perry L.J., Taylor P., Challberg M.D.; "Structures of herpes simplex virus type 1 genes required for replication of virus DNA."; J. Virol. 62:444-453(1988).
[3]	FUNCTION. DOI=10.1128/JVI.75.22.10923-10932.2001; PubMed=11602732 [NCBI, ExPASy, EBI, Israel, Japan] Newcomb W.W., Juhas R.M., Thomsen D.R., Homa F.L., Burch A.D., Weller S.K., Brown J.C.; "The UL6 gene product forms the portal for entry of DNA into the herpes simplex virus capsid."; J. Virol. 75:10923-10932(2001).
[4]	INTERACTION WITH UL15 AND UL28, AND SUBCELLULAR LOCATION. DOI=10.1128/JVI.77.11.6351-6358.2003; PubMed=12743292 [NCBI, ExPASy, EBI, Israel, Japan] White C.A., Stow N.D., Patel A.H., Hughes M., Preston V.G.; "Herpes simplex virus type 1 portal protein UL6 interacts with the putative terminase subunits UL15 and UL28."; J. Virol. 77:6351-6358(2003).
[5]	HOMODODECAMERIZATION. DOI=10.1128/JVI.78.22.12668-12671.2004; PubMed=15507654 [NCBI, ExPASy, EBI, Israel, Japan] Trus B.L., Cheng N., Newcomb W.W., Homa F.L., Brown J.C., Steven A.C.; "Structure and polymorphism of the UL6 portal protein of herpes simplex virus type 1."; J. Virol. 78:12668-12671(2004).
[6]	SUBCELLULAR LOCATION. DOI=10.1128/JVI.01364-06; PubMed=16920825 [NCBI, ExPASy, EBI, Israel, Japan] Wills E., Scholtes L., Baines J.D.; "Herpes simplex virus 1 DNA packaging proteins encoded by UL6, UL15, UL17, UL28, and UL33 are located on the external surface of the viral capsid."; J. Virol. 80:10894-10899(2006).

Comments

FUNCTION: Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocate the viral DNA, termed terminase.
SUBUNIT: Homododecamerizes. Interacts with putative terminase subunit UL15 and UL28.
SUBCELLULAR LOCATION: Virion. Host nucleus.
SIMILARITY: Belongs to the herpesviridae portal protein family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X14112; CAA32342.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M19119; AAA45818.2; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

F28133; WMBEX6.

RefSeq

NP_044607.1; -.

3D structure databases

ModBase

P10190.

Ontologies

GO:0042025;	Cellular component: host cell nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005634;	Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
GO:0019012;	Cellular component: virion (inferred from electronic annotation from UniProtKB-SubCell).
GO:0006323;	Biological process: DNA packaging (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002660; Herpes_UL6.
Graphical view of domain structure.

Pfam

PF01763; Herpes_UL6; 1.
Pfam graphical view of domain structure.

ProDom

PD003210; Herpes_UL6; 1.
[Domain structure / List of seq. sharing at least 1 domain]

Genome annotation databases

GeneID

2703429; -.

Other

ProtoNet

P10190.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; DNA packaging; Nucleus; Virion.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 676`	`676`		`Portal protein UL6.`	`PRO_0000115903`

Sequence information

Length: 676 AA [This is the length of the unprocessed precursor]

Molecular weight: 74092 Da [This is the MW of the unprocessed precursor]

CRC64: 8CF9D73C6313FAE9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTAPRSRAPT TRARGDTEAL CSPEDGWVKV HPSPGTMLFR EILHGQLGYT EGQGVYNVVR 

        70         80         90        100        110        120 
SSEATTRQLQ AAIFHALLNA TTYRDLEADW LGHVAARGLQ PQRLVRRYRN AREADIAGVA 

       130        140        150        160        170        180 
ERVFDTWRNT LRTTLLDFAH GLVACFAPGG PSGPSSFPKY IDWLTCLGLV PILRKRQEGG 

       190        200        210        220        230        240 
VTQGLRAFLK QHPLTRQLAT VAEAAERAGP GFFELALAFD STRVADYDRV YIYYNHRRGD 

       250        260        270        280        290        300 
WLVRDPISGQ RGECLVLWPP LWTGDRLVFD SPVQRLFPEI VACHSLREHA HVCRLRNTAS 

       310        320        330        340        350        360 
VKVLLGRKSD SERGVAGAAR VVNKVLGEDD ETKAGSAASR LVRLIINMKG MRHVGDINDT 

       370        380        390        400        410        420 
VRSYLDEAGG HLIDAPAVDG TLPGFGKGGN SRGSAGQDQG GRAPQLRQAF RTAVVNNING 

       430        440        450        460        470        480 
VLEGYINNLF GTIERLRETN AGLATQLQER DRELRRATAG ALERQQRAAD LAAESVTGGC 

       490        500        510        520        530        540 
GSRPAGADLL RADYDIIDVS KSMDDDTYVA NSFQHPYIPS YAQDLERLSR LWEHELVRCF 

       550        560        570        580        590        600 
KILCHRNNQG QETSISYSSG AIAAFVAPYF ESVLRAPRVG APITGSDVIL GEEELWDAVF 

       610        620        630        640        650        660 
KKTRLQTYLT DIAALFVADV QHAALPPPPS PVGADFRPGA SPRGRSRSRS PGRTARGAPD 

       670 
QGGGIGHRDG RRDGRR

P10190 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools