[1]	NUCLEOTIDE SEQUENCE [MRNA]. STRAIN=280202-Berlin; Denk U., Schneider P., Breitenbach M., Richter K., Radauer C., Teige M., Simon-Nobbe B.; "Cladosporium herbarum NADP-dependent mannitol dehydrogenase, a major allergen."; Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: D-mannitol + NADP⁺ = D-fructose + NADPH.
ALLERGEN: Causes an allergic reaction in human.
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY191816; AAO91801.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

P0C0Y5.

Enzyme and pathway databases

BRENDA

1.1.1.138; 279238.
1.1.2.2; 279238.

Ontologies

GO:0005488;	Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0050085;	Molecular function: mannitol 2-dehydrogenase (NADP+) activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002198; DH_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DH.
IPR016040; NAD(P)-bd_dom.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PRINTS

PR00081; GDHRDH.

PROSITE

PS00061; ADH_SHORT; FALSE_NEG.

Other

ProtoNet

P0C0Y5.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Allergen; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 267`	`267`	`Probable NADP-dependent mannitol dehydrogenase.`	`PRO_0000054728`
`NP_BIND`	`30 55`	`26`	`NADP (By similarity).`
`NP_BIND`	`161 180`	`20`	`NADP (By similarity).`
`ACT_SITE`	`175 175`		`Proton acceptor (By similarity).`
`BINDING`	`160 160`		`Substrate (By similarity).`

Sequence information

Length: 267 AA [This is the length of the unprocessed precursor]

Molecular weight: 28464 Da [This is the MW of the unprocessed precursor]

CRC64: 4CF5EA012D71D446 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPGQQATKHE SLLDQLSLKG KVVVVTGASG PKGMGIEAAR GCAEMGAAVA ITYASRAQGA 

        70         80         90        100        110        120 
EENVKELEKT YGIKAKAYKC QVDSYESCEK LVKDVVADFG QIDAFIANAG ATADSGILDG 

       130        140        150        160        170        180 
SVEAWNHVVQ VDLNGTFHCA KAVGHHFKER GTGSLVITAS MSGHIANFPQ EQTSYNVAKA 

       190        200        210        220        230        240 
GCIHMARSLA NEWRDFARVN SISPGYIDTG LSDFVPKETQ QLWHSMIPMG RDGLAKELKG 

       250        260 
AYVYFASDAS TYTTGADLLI DGGYTTR

P0C0Y5 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools