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UniProtKB/Swiss-Prot entry P0A9C4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GALM_SHIFL
Primary accession number P0A9C4
Secondary accession number P40681
Integrated into Swiss-Prot on July 19, 2005
Sequence was last modified on July 19, 2005 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 30)
Name and origin of the protein
Protein name Aldose 1-epimerase
Synonyms EC 5.1.3.3
Galactose mutarotase
Type-1 mutarotase
Gene name
Name: galM
OrderedLocusNames: SF0548, S0556
From
Shigella flexneri [TaxID: 623] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Shigella.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=301 / Serotype 2a;
DOI=10.1093/nar/gkf566; PubMed=12384590 [NCBI, ExPASy, EBI, Israel, Japan]
Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157.";
Nucleic Acids Res. 30:4432-4441(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700930 / 2457T / Serotype 2a;
DOI=10.1128/IAI.71.5.2775-2786.2003; PubMed=12704152 [NCBI, ExPASy, EBI, Israel, Japan]
Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T.";
Infect. Immun. 71:2775-2786(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE005674; AAN42192.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014073; AAP16065.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_706485.1; -.
NP_836259.1; -.
3D structure databases
ModBase P0A9C4.
Enzyme and pathway databases
BioCyc SFLE198214:AAN42192.1-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004034; Molecular function: aldose 1-epimerase activity (inferred from electronic annotation from InterPro).
GO:0030246; Molecular function: carbohydrate binding (inferred from electronic annotation from InterPro).
GO:0006012; Biological process: galactose metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR008183; Ald1_epimerase.
IPR015443; Ald_epimerase.
IPR013458; GalM_Leloir.
IPR014718; Glyco_hydro-type_carb-bd_sub.
Graphical view of domain structure.
Gene3D G3DSA:2.70.98.10; Glyco_hydro_42_D5; 1.
PANTHER PTHR10091; Ald_epimerase; 1.
Pfam PF01263; Aldose_epim; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR02636; galM_Leloir; 1.
PROSITE PS00545; ALDOSE_1_EPIMERASE; 1.
Genome annotation databases
GeneID 1023468; -.
1076990; -.
GenomeReviews AE005674_GR; SF0548.
AE014073_GR; S0556.
KEGG sfl:SF0548; -.
sfx:S0556; -.
Phylogenomic databases
HOGENOM P0A9C4; -.
Genome annotation databases
CMR P0A9C4; SF0548.
Other
ProtoNet P0A9C4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Complete proteome; Cytoplasm; Isomerase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   346  346     Aldose 1-epimerase. PRO_0000197444
ACT_SITE   175   175        Proton donor (By similarity). 
ACT_SITE   309   309        Proton acceptor (By similarity). 
BINDING   79    79        Substrate (By similarity). 
BINDING   245   245        Substrate (By similarity). 
Sequence information
Length: 346 AA [This is the length of the unprocessed precursor] Molecular weight: 38190 Da [This is the MW of the unprocessed precursor] CRC64: 4373732BAEA83E1D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLNETPALAP DGQPYRLLTL RNNAGMVVTL MDWGATLLSA RIPLSDGSVR EALLGCASPE 

        70         80         90        100        110        120 
CYQDQAAFLG ASIGRYANRI ANSRYTFDGE TVTLSPSQGV NQLHGGPEGF DKRRWQIVNQ 

       130        140        150        160        170        180 
NDRQVLFALS SDDGDQGFPG NLGATVQYRL TDDNRISITY RATVDKPCPV NMTNHVYFNL 

       190        200        210        220        230        240 
DGEQSDVRNH KLQILADEYL PVDEGGIPHD GLKSVAGTSF DFRSAKIIAS EFLADDDQRK 

       250        260        270        280        290        300 
VKGYDHAFLL QAKGDGKKVA AHVWSADEKL QLKVYTTAPA LQFYSGNFLG GTPSRGTEPY 

       310        320        330        340 
ADWQGLALES EFLPDSPNHP EWPQPDCFLR PGEEYSSLTE YQFIAE 

P0A9C4 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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