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UniProtKB/Swiss-Prot entry P0A6X0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GSH1_ECOL6
Primary accession number P0A6X0
Secondary accession numbers P06980 P78228
Integrated into Swiss-Prot on April 1, 1988
Sequence was last modified on March 29, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 20)
Name and origin of the protein
Protein name Glutamate--cysteine ligase
Synonyms EC 6.3.2.2
Gamma-glutamylcysteine synthetase
Gamma-ECS
GCS
Gene name
Name: gshA
OrderedLocusNames: c3245
From
Escherichia coli O6 [TaxID: 217992] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=O6:H1 / CFT073 / ATCC 700928 / UPEC;
DOI=10.1073/pnas.252529799; PubMed=12471157 [NCBI, ExPASy, EBI, Israel, Japan]
Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D., Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F., Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T., Donnenberg M.S., Blattner F.R.;
"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli.";
Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE014075; AAN81697.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_755127.1; -.
3D structure databases
SMR P0A6X0; 1-515.
ModBase P0A6X0.
Ontologies
GO
GO:0004357; Molecular function: glutamate-cysteine ligase activity (inferred from electronic annotation from HAMAP).
GO:0006750; Biological process: glutathione biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00578; -; 1.
PBIL [Tree]
InterPro IPR007370; Glu_cys_ligase.
IPR006334; Glut_cys_ligase.
Graphical view of domain structure.
Pfam PF04262; Glu_cys_ligase; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01434; glu_cys_ligase; 1.
Genome annotation databases
GeneID 1039015; -.
GenomeReviews AE014075_GR; c3245.
KEGG ecc:c3245; -.
Phylogenomic databases
HOGENOM P0A6X0; -.
Genome annotation databases
CMR P0A6X0; c3245.
Other
ProtoNet P0A6X0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glutathione biosynthesis; Ligase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   518  518     Glutamate--cysteine ligase. PRO_0000192525
Sequence information
Length: 518 AA [This is the length of the unprocessed precursor] Molecular weight: 58269 Da [This is the MW of the unprocessed precursor] CRC64: 4E58C447B4D7FF16 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MIPDVSQALA WLEKHPQALK GIQRGLERET LRVNADGTLA TTGHPEALGS ALTHKWITTD 

        70         80         90        100        110        120 
FAEALLEFIT PVDGDIEHML TFMRDLHRYT ARNMGDERMW PLSMPCYIAE GQDIELAQYG 

       130        140        150        160        170        180 
TSNTGRFKTL YREGLKNRYG ALMQTISGVH YNFSLPMAFW QAKCGDISGA DAKEKISAGY 

       190        200        210        220        230        240 
FRVIRNYYRF GWVIPYLFGA SPAICSSFLQ GKPTSLPFEK TECGMYYLPY ATSLRLSDLG 

       250        260        270        280        290        300 
YTNKSQSNLG ITFNDLYEYV AGLKQAIKTP SEEYAKIGIE KDGKRLQINS NVLQIENELY 

       310        320        330        340        350        360 
APIRPKRVTR SGESPSDALL RGGIEYIEVR SLDINPFSPI GVDEQQVRFL DLFMVWCALA 

       370        380        390        400        410        420 
DAPEMSSSEL ACTRVNWNRV ILEGRKPGLT LGIGCETAQF PLPQVGKDLF RDLKRVAQTL 

       430        440        450        460        470        480 
DSINGGEAYQ KVCDELVACF DNPDLTFSAR ILRSMIDTGI GGTGKAFAEA YRNLLREEPL 

       490        500        510 
EILREEDFVA EREASERRQQ EMEAADTEPF AVWLEKHA
P0A6X0 in FASTA format

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