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UniProtKB/Swiss-Prot entry P0A6L0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DEOC_ECOLI
Primary accession number P0A6L0
Secondary accession numbers P00882 Q2M5T6
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on March 29, 2005 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 36)
Name and origin of the protein
Protein name Deoxyribose-phosphate aldolase
Synonyms EC 4.1.2.4
Phosphodeoxyriboaldolase
Deoxyriboaldolase
DERA
Gene name
Name: deoC
Synonyms: dra, thyR
OrderedLocusNames: b4381, JW4344
From
Escherichia coli (strain K12) [TaxID: 83333] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=K12;
PubMed=6749498 [NCBI, ExPASy, EBI, Israel, Japan]
Valentin-Hansen P., Boetius F., Hammer-Jespersen K., Svendsen I.;
"The primary structure of Escherichia coli K12 2-deoxyribose 5-phosphate aldolase. Nucleotide sequence of the deoC gene and the amino acid sequence of the enzyme.";
Eur. J. Biochem. 125:561-566(1982).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
DOI=10.1093/nar/23.12.2105; PubMed=7610040 [NCBI, ExPASy, EBI, Israel, Japan]
Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
"Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes.";
Nucleic Acids Res. 23:2105-2119(1995).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
DOI=10.1126/science.277.5331.1453; PubMed=9278503 [NCBI, ExPASy, EBI, Israel, Japan]
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1474(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
DOI=10.1038/msb4100049; PubMed=16738553 [NCBI, ExPASy, EBI, Israel, Japan]
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[5]
X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS), ACTIVE SITE, AND MUTAGENESIS.
DOI=10.1126/science.1063601; PubMed=11598300 [NCBI, ExPASy, EBI, Israel, Japan]
Heine A., DeSantis G., Luz J.G., Mitchell M., Wong C.-H., Wilson I.A.;
"Observation of covalent intermediates in an enzyme mechanism at atomic resolution.";
Science 294:369-374(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X03224; CAA26974.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U14003; AAA97277.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U00096; AAC77334.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP009048; BAE78370.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A01102; ADECD.
RefSeq AP_004869.1; -.
NP_418798.1; -.
3D structure databases
PDB
1JCJ; X-ray; 1.10 A; A/B=1-259.[ExPASy / RCSB / EBI]
1JCL; X-ray; 1.05 A; A/B=1-259.[ExPASy / RCSB / EBI]
1KTN; X-ray; 1.40 A; A/B=1-250.[ExPASy / RCSB / EBI]
1P1X; X-ray; 0.99 A; A/B=1-259.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1JCJ; -.
1JCL; -.
1KTN; -.
1P1X; -.
ModBase P0A6L0.
Protein-protein interaction databases
IntAct P0A6L0; -.
Enzyme and pathway databases
BioCyc EcoCyc:DEOXYRIBOSE-P-ALD-MON; -.
MetaCyc:DEOXYRIBOSE-P-ALD-MON; -.
2D gel databases
SWISS-2DPAGE P0A6L0; -.
Organism-specific databases
EchoBASE EB0217; -.
EcoGene EG10221; deoC.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from UniProtKB).
GO:0005739; Cellular component: mitochondrion (inferred from direct assay from UniProtKB).
QuickGo view.
Family and domain databases
HAMAP MF_00592; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR011343; DeoC.
IPR002915; DeoC/AroFGH_arch.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
PANTHER PTHR10889; DeoC; 1.
Pfam PF01791; DeoC; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001357; DeoC; 1.
TIGRFAMs TIGR00126; deoC; 1.
BLOCKS P0A6L0.
Genome annotation databases
GeneID 948902; -.
GenomeReviews U00096_GR; b4381.
AP009048_GR; JW4344.
KEGG ecj:JW4344; -.
eco:b4381; -.
Phylogenomic databases
HOGENOM P0A6L0; -.
Genome annotation databases
CMR P0A6L0; b4381.
Other
ProtoNet P0A6L0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Complete proteome; Cytoplasm; Lyase; Schiff base.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   259  259     Deoxyribose-phosphate aldolase. PRO_0000057296
ACT_SITE   167   167        Schiff-base intermediate with acetaldehyde. 
ACT_SITE   201   201         
CONFLICT   18    18        T -> N (in Ref. 1; CAA26974). 
HELIX   3    13  11      
STRAND   15    18  4      
HELIX   26    36  11      
STRAND   44    47  4      
HELIX   50    52  3      
HELIX   53    62  10      
STRAND   68    75  8      
TURN   76    78  3      
HELIX   83    96  14      
STRAND   99   104  6      
HELIX   107   111  5      
HELIX   116   131  16      
STRAND   135   139  5      
HELIX   142   145  4      
HELIX   148   160  13      
STRAND   164   167  4      
HELIX   179   192  14      
TURN   195   197  3      
STRAND   199   201  3      
STRAND   203   205  3      
HELIX   209   223  15      
TURN   230   232  3      
STRAND   235   239  5      
HELIX   241   248  8      
Sequence information
Length: 259 AA [This is the length of the unprocessed precursor] Molecular weight: 27734 Da [This is the MW of the unprocessed precursor] CRC64: ABA50C625195D494 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTDLKASSLR ALKLMDLTTL NDDDTDEKVI ALCHQAKTPV GNTAAICIYP RFIPIARKTL 

        70         80         90        100        110        120 
KEQGTPEIRI ATVTNFPHGN DDIDIALAET RAAIAYGADE VDVVFPYRAL MAGNEQVGFD 

       130        140        150        160        170        180 
LVKACKEACA AANVLLKVII ETGELKDEAL IRKASEISIK AGADFIKTST GKVAVNATPE 

       190        200        210        220        230        240 
SARIMMEVIR DMGVEKTVGF KPAGGVRTAE DAQKYLAIAD ELFGADWADA RHYRFGASSL 

       250 
LASLLKALGH GDGKSASSY 

P0A6L0 in FASTA format

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