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UniProtKB/Swiss-Prot entry P0A3D8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HEMH_BRUAB
Primary accession number P0A3D8
Secondary accession numbers Q57A07 Q939N8 Q93TG2
Integrated into Swiss-Prot on March 15, 2005
Sequence was last modified on June 21, 2005 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 29)
Name and origin of the protein
Protein name Ferrochelatase
Synonyms EC 4.99.1.1
Protoheme ferro-lyase
Heme synthetase
Gene name
Name: hemH
OrderedLocusNames: BruAb2_0076
From
Brucella abortus [TaxID: 235] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=544 / Biovar 1;
Tibor A., Aidant N., Letesson J.-J.;
"Omp10 gene is located upstream of hemH in Brucella.";
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1128/IAI.69.10.6225-6230.2001; PubMed=11553564 [NCBI, ExPASy, EBI, Israel, Japan]
Almiron M., Martinez M., Sanjuan N., Ugalde R.A.;
"Ferrochelatase is present in Brucella abortus and is critical for its intracellular survival and virulence.";
Infect. Immun. 69:6225-6230(2001).
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=9-941 / Biovar 1;
DOI=10.1128/JB.187.8.2715-2726.2005; PubMed=15805518 [NCBI, ExPASy, EBI, Israel, Japan]
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.;
"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis.";
J. Bacteriol. 187:2715-2726(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF358663; AAK43712.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY027659; AAK14798.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE017224; AAX75527.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_222888.1; -.
3D structure databases
ModBase P0A3D8.
Enzyme and pathway databases
BioCyc BABO262698:BRUAB2_0076-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004325; Molecular function: ferrochelatase activity (inferred from electronic annotation from HAMAP).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006783; Biological process: heme biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00323; -; 1.
PBIL [Tree]
InterPro IPR001015; Ferrochelatase.
Graphical view of domain structure.
PANTHER PTHR11108; Ferrochelatase; 1.
Pfam PF00762; Ferrochelatase; 1.
Pfam graphical view of domain structure.
ProDom PD002792; Ferrochelatase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00109; hemH; 1.
PROSITE PS00534; FERROCHELATASE; 1.
Genome annotation databases
GeneID 3341660; -.
GenomeReviews AE017224_GR; BruAb2_0076.
KEGG bmb:BruAb2_0076; -.
Phylogenomic databases
HOGENOM P0A3D8; -.
Genome annotation databases
CMR P0A3D8; BruAb2_0076.
Other
ProtoNet P0A3D8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Heme biosynthesis; Iron; Lyase; Metal-binding; Porphyrin biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   352  352     Ferrochelatase. PRO_0000175120
METAL   222   222        Iron (By similarity). 
METAL   303   303        Iron (By similarity). 
CONFLICT   208   208        A -> V (in Ref. 2; AAK14798). 
CONFLICT   289   289        L -> S (in Ref. 1; AAK43712). 
Sequence information
Length: 352 AA [This is the length of the unprocessed precursor] Molecular weight: 40083 Da [This is the MW of the unprocessed precursor] CRC64: 4D76D2727A435D2D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSGTDKVRVN VSQTAQTPLH TSAKLPKVGV LLVNLGTPDG TSYGPMRRYL AEFLSDRRVI 

        70         80         90        100        110        120 
EWSRLIWYPI LYGIVLNTRP RRSGRLYDRI WNHENNESPL RTYTRAQGEK LAKALSDQPN 

       130        140        150        160        170        180 
VVVDWAMRYG QPSIESITDR LLQQGCERIV IFPLYPQYSA TTTATVNDKF FEALMKKRFM 

       190        200        210        220        230        240 
PAIRTVPSYE AEPVYIDALA RSVEKHLATL SFKPEVILTS YHGIPKSYSD KGDPYRQQCL 

       250        260        270        280        290        300 
ETTRLLRERL GLGEDEMRAT FQSRFGPEEW LQPYTDETVK ELAKNGVKLV AVLNPGFVAD 

       310        320        330        340        350 
CLETVDEIGN EAAEEFLENG GENFSHIPCL NDSEEGMKVI ETLVRRELLG WV
P0A3D8 in FASTA format

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