[1]	NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 32-57. PubMed=2382765 [NCBI, ExPASy, EBI, Israel, Japan] el Meanawy M.A., Aji T., Phillips N.F.B., Davis R.E., Salata R.A., Malchotra I., McClain D., Aikawa M., Davis A.H.; "Definition of the complete Schistosoma mansoni hemoglobinase mRNA sequence and gene expression in developing parasites."; Am. J. Trop. Med. Hyg. 43:67-78(1990).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1016/0166-6851(89)90025-X; PubMed=2725581 [NCBI, ExPASy, EBI, Israel, Japan] Klinkert M.-Q., Felleisen R., Link G., Ruppel A., Beck E.; "Primary structures of Sm31/32 diagnostic proteins of Schistosoma mansoni and their identification as proteases."; Mol. Biochem. Parasitol. 33:113-122(1989).
[3]	NUCLEOTIDE SEQUENCE [MRNA] OF 77-429. PubMed=3305515 [NCBI, ExPASy, EBI, Israel, Japan] Davis A.H., Nanduri J., Watson D.C.; "Cloning and gene expression of Schistosoma mansoni protease."; J. Biol. Chem. 262:12851-12855(1987).

Comments

FUNCTION: This protease is used by the parasite for degradation of the host globin.
CATALYTIC ACTIVITY: Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.
SIMILARITY: Belongs to the peptidase C13 family [view classification].

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M21308; AAA29895.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
M17423; AAA29916.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A60145; A60145.

3D structure databases

ModBase

P09841.

Ontologies

GO:0004197;	Molecular function: cysteine-type endopeptidase activity (inferred from electronic annotation from InterPro).
GO:0006508;	Biological process: proteolysis (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR001096; Peptidase_C13.
Graphical view of domain structure.

PANTHER

PTHR12000; Peptidase_C13; 1.

Pfam

PF01650; Peptidase_C13; 1.
Pfam graphical view of domain structure.

PRINTS

PR00776; HEMOGLOBNASE.

ProtoNet

P09841.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Hydrolase; Protease; Signal; Thiol protease.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 19`	`19`	`Potential.`
`PROPEP`	`20 31`	`12`	`Potential.`	`PRO_0000026508`
`CHAIN`	`32 291`	`260`	`Hemoglobinase.`	`PRO_0000026509`
`PROPEP`	`292 429`	`138`	`Potential.`	`PRO_0000026510`
`ACT_SITE`	`151 151`		`Potential.`
`CONFLICT`	`91 91`		`P -> L (in Ref. 2; AAA29895).`
`CONFLICT`	`115 115`		`N -> K (in Ref. 2; AAA29895).`
`CONFLICT`	`216 216`		`S -> P (in Ref. 2; AAA29895).`
`CONFLICT`	`297 297`		`S -> T (in Ref. 2; AAA29895).`
`CONFLICT`	`302 302`		`P -> S (in Ref. 2; AAA29895).`
`CONFLICT`	`310 310`		`I -> V (in Ref. 3; AAA29916).`

Sequence information

Length: 429 AA [This is the length of the unprocessed precursor]

Molecular weight: 49032 Da [This is the MW of the unprocessed precursor]

CRC64: 333C9DA086C83B0F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MMLFSLFLIS ILHILLVKCQ LDTNYEVSDE TVSDNNKWAV LVAGSNGYPN YRHQADVCHA 

        70         80         90        100        110        120 
YHVLRSKGIK PEHIITMMYD DIAYNLMNPF PGKLFNDYNH KDWYEGVVID YRGKNVNSKT 

       130        140        150        160        170        180 
FLKVLKGDKS AGGKVLKSGK NDDVFIYFTD HGAPGLIAFP DDELYAKEFM STLKYLHSHK 

       190        200        210        220        230        240 
RYSKLVIYIE ANESGSMFQQ ILPSNLSIYA TTAANSTECS YSTFCGDPTI TTCLADLYSY 

       250        260        270        280        290        300 
NWIVDSQTHH LTQRTLDQQY KEVKRETDLS HVQRYGDTRM GKLYVSEFQG SRDKSSSEND 

       310        320        330        340        350        360 
EPPMKPRHSI ASRDIPLHTL HRQIMMTNNA EDKSFLMQIL GLKLKRRDLI EDTMKLIVKV 

       370        380        390        400        410        420 
MNNEEIPNTK ATIDQTLDCT ESVYEQFKSK CFTLQQAPEV GGHFSTLYNY CADGYTAETI 


NEAIIKICG

P09841 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools