ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P09429


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name HMGB1_HUMAN
Primary accession number P09429
Secondary accession numbers A5D8W9 Q14321 Q5T7C3 Q6IBE1
Integrated into Swiss-Prot on July 1, 1989
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    June 16, 2009 (Entry version 101)
Name and origin of the protein
Protein name High mobility group protein B1
Synonyms High mobility group protein 1
HMG-1
Gene name
Name: HMGB1
Synonyms: HMG1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1093/nar/17.3.1197; PubMed=2922262 [NCBI, ExPASy, EBI, Israel, Japan]
Wen L., Huang J.K., Johnson B.H., Reeck G.R.;
"A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1.";
Nucleic Acids Res. 17:1197-1214(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.1996.0369; PubMed=8661151 [NCBI, ExPASy, EBI, Israel, Japan]
Ferrari S., Finelli P., Rocchi M., Bianchi M.E.;
"The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13.";
Genomics 35:367-371(1996).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS ARG-11; GLU-149 AND GLY-190.
DOI=10.1002/(SICI)1097-0215(19970220)74:1<1::AID-IJC1>3.0.CO;2-6; PubMed=9036861 [NCBI, ExPASy, EBI, Israel, Japan]
Xiang Y.-Y., Wang D.-Y., Tanaka M., Suzuki M., Kiyokawa E., Igarashi H., Niato Y., Shen Q., Sugimura H.;
"Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa.";
Int. J. Cancer 74:1-6(1997).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1111/j.1399-0039.2007.00854.x; PubMed=17610420 [NCBI, ExPASy, EBI, Israel, Japan]
Kornblit B., Munthe-Fog L., Petersen S., Madsen H., Vindeloev L., Garred P.;
"The genetic variation of the human HMGB1 gene.";
Tissue Antigens 70:151-156(2007).
[5]
NUCLEOTIDE SEQUENCE [MRNA].
He F.T., Yang Z.H., Ji Q., Li R., Peng J., Jiang Y., Zhong X.;
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cerebellum;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Small intestine;
The German cDNA consortium;
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLN-156.
SeattleSNPs variation discovery resource;
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
[11]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02379; PubMed=15057823 [NCBI, ExPASy, EBI, Israel, Japan]
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
"The DNA sequence and analysis of human chromosome 13.";
Nature 428:522-528(2004).
[12]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[13]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, Cervix, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[14]
PROTEIN SEQUENCE OF 58-65 AND 113-127.
TISSUE=Mammary carcinoma;
DOI=10.1002/elps.1150180342; PubMed=9150946 [NCBI, ExPASy, EBI, Israel, Japan]
Rasmussen R.K., Ji H., Eddes J.S., Moritz R.L., Reid G.E., Simpson R.J., Dorow D.S.;
"Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.";
Electrophoresis 18:588-598(1997).
[15]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-30, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.molcel.2006.06.026; PubMed=16916647 [NCBI, ExPASy, EBI, Israel, Japan]
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.";
Mol. Cell 23:607-618(2006).
[16]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0611217104; PubMed=17287340 [NCBI, ExPASy, EBI, Israel, Japan]
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.";
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
[17]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35 AND SER-100, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[18]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
[19]
STRUCTURE BY NMR OF 1-166.
RIKEN structural genomics initiative (RSGI);
"Solution structure of the tandem HMG box domain from human high mobility group protein B1.";
Submitted (FEB-2008) to the PDB data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X12597; CAA31110.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U51677; AAB08987.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D63874; BAA09924.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EF157968; ABM47301.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY377859; AAQ91389.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK291494; BAF84183.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK122825; BAG53745.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR749614; CAH18408.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR456863; CAG33144.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT006940; AAP35586.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT020159; AAV38961.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
EU012027; ABS29271.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL353648; CAI15600.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471075; EAX08457.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC003378; AAH03378.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC030981; AAH30981.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC066889; AAH66889.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC067732; AAH67732.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC141844; AAI41845.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00419258; -.
PIR S02826; S02826.
RefSeq NP_002119.1; -.
UniGene Hs.593339
3D structure databases
PDB
2YRQ; NMR; -; A=1-166.[ExPASy / RCSB / EBI]
PDBsum 2YRQ; -.
ModBase P09429.
Protein-protein interaction databases
DIP DIP:24195N; -.
IntAct P09429; 7.
PTM databases
PhosphoSite P09429; -.
Enzyme and pathway databases
Pathway_Interaction_DB amb2_neutrophils_pathway; amb2 Integrin signaling.
2D gel databases
DOSAC-COBS-2DPAGE P09429; -.
Organism-specific databases
GeneCards GC13M029930; -.
GC22P025275; -.
H-InvDB HIX0011209; -.
HIX0030745; -.
HIX0059248; -.
HGNC HGNC:4983; HMGB1.
GenAtlas HMGB1.
HPA CAB005873; -.
HPA003506; -.
MIM 163905; gene. [NCBI / EBI]
PharmGKB PA188; -.
Gene expression databases
ArrayExpress P09429; -.
Bgee P09429; -.
CleanEx HS_HMGB1; -.
GermOnline ENSG00000189403; Homo sapiens.
Ontologies
GO
GO:0000793; Cellular component: condensed chromosome (inferred from direct assay from UniProtKB).
GO:0005730; Cellular component: nucleolus (inferred from direct assay from HPA).
GO:0008301; Molecular function: DNA bending activity (traceable author statement from UniProtKB).
GO:0008134; Molecular function: transcription factor binding (traceable author statement from UniProtKB).
GO:0006916; Biological process: anti-apoptosis (traceable author statement from UniProtKB).
GO:0006288; Biological process: base-excision repair, DNA ligation (inferred from direct assay from UniProtKB).
GO:0006310; Biological process: DNA recombination (traceable author statement from UniProtKB).
GO:0006268; Biological process: DNA unwinding during replication (non-traceable author statement from UniProtKB).
GO:0006325; Biological process: establishment or maintenance of chromatin architecture (traceable author statement from UniProtKB).
GO:0017055; Biological process: negative regulation of transcriptional preinitiation complex assembly (inferred from direct assay from UniProtKB).
GO:0007165; Biological process: signal transduction (traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR017967; HMG_boxA_CS.
IPR000910; HMG_HMG1/HMG2.
IPR000135; HMG_HMG1/HMG2_subgr.
Graphical view of domain structure.
Gene3D G3DSA:1.10.30.10; HMG-box; 2.
Pfam PF00505; HMG_box; 2.
Pfam graphical view of domain structure.
PRINTS PR00886; HIGHMOBLTY12.
SMART SM00398; HMG; 2.
SMART graphical view of domain structure.
PROSITE PS00353; HMG_BOX_1; 1.
PS50118; HMG_BOX_2; 2.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PeptideAtlas P09429; -.
PRIDE P09429; -.
Genome annotation databases
Ensembl ENSG00000189403; Homo sapiens. [Contig view]
GeneID 3146; -.
KEGG hsa:3146; -.
Phylogenomic databases
HOGENOM P09429; -.
HOVERGEN P09429; -.
OMA P09429; MWNSSSA.
Other
NextBio 12470; -.
SOURCE HMGB1; Homo sapiens.
ProtoNet P09429.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Acetylation; Chromosomal protein; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   215  214     High mobility group protein B1. PRO_0000048526
DNA_BIND   9    79  71     HMG box 1. 
DNA_BIND   95   163  69     HMG box 2. 
COMPBIAS   186   215  30     Asp/Glu-rich (acidic). 
MOD_RES   30    30        N6-acetyllysine. 
MOD_RES   35    35        Phosphoserine. 
MOD_RES   100   100        Phosphoserine. 
VARIANT   11    11  1     G -> R (in gastric-carcinoma cell line). VAR_046451 
VARIANT   149   149  1     A -> E (in gastric-carcinoma cell line). VAR_046452 
VARIANT   156   156  1     E -> Q. VAR_046453 
VARIANT   190   190  1     D -> G (in gastric-carcinoma cell line). VAR_046454 
CONFLICT   143   143        P -> H (in Ref. 13; AAI41845). 
CONFLICT   215   215        E -> D (in Ref. 8; CAG33144). 
Sequence information
Length: 215 AA [This is the length of the unprocessed precursor] Molecular weight: 24894 Da [This is the MW of the unprocessed precursor] CRC64: 8A868CF277D417B5 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF 

        70         80         90        100        110        120 
EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL 

       130        140        150        160        170        180 
SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK 

       190        200        210 
SKKKKEEEED EEDEEDEEEE EDEEDEDEEE DDDDE 

P09429 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!