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UniProtKB/Swiss-Prot entry P09326


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CD48_HUMAN
Primary accession number P09326
Secondary accession numbers None
Integrated into Swiss-Prot on July 1, 1989
Sequence was last modified on November 1, 1991 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 115)
Name and origin of the protein
Protein name CD48 antigen [Precursor]
Synonyms B-lymphocyte activation marker BLAST-1
BCM1 surface antigen
Leukocyte antigen MEM-102
TCT.1
CD48 antigen
Gene name
Name: CD48
Synonyms: BCM1, BLAST1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1007/BF00210824; PubMed=1999351 [NCBI, ExPASy, EBI, Israel, Japan]
Vaughan H.A., Henning M.M., Purcell D.F.J., McKenzie I.F.C., Sandrin M.S.;
"The isolation of cDNA clones for CD48.";
Immunogenetics 33:113-117(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1007/BF00210823; PubMed=1999350 [NCBI, ExPASy, EBI, Israel, Japan]
Korinek V., Stefanova I., Angelisova P., Hilbert I., Horejsi V.;
"The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1.";
Immunogenetics 33:108-112(1991).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2828034 [NCBI, ExPASy, EBI, Israel, Japan]
Staunton D.E., Thorley-Lawson D.A.;
"Molecular cloning of the lymphocyte activation marker Blast-1.";
EMBO J. 6:3695-3701(1987).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=B-cell;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27.
PubMed=1847502 [NCBI, ExPASy, EBI, Israel, Japan]
Fisher R.C., Thorley-Lawson D.A.;
"Characterization of the Epstein-Barr virus-inducible gene encoding the human leukocyte adhesion and activation antigen BLAST-1 (CD48).";
Mol. Cell. Biol. 11:1614-1623(1991).
[7]
PARTIAL PROTEIN SEQUENCE.
DOI=10.1084/jem.173.6.1339; PubMed=1827826 [NCBI, ExPASy, EBI, Israel, Japan]
del Porto P., Mami-Chouaib F., Bruneau J.-M., Jitsukawa S., Dumas J., Harnois M., Hercend T.;
"TCT.1, a target molecule for gamma/delta T cells, is encoded by an immunoglobulin superfamily gene (Blast-1) located in the CD1 region of human chromosome 1.";
J. Exp. Med. 173:1339-1344(1991).
[8]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
[9]
STRUCTURE BY NMR OF 24-140.
RIKEN structural genomics initiative (RSGI);
"Solution structure of the first Ig-like domain from human CD48 antigen.";
Submitted (AUG-2007) to the PDB data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M59904; AAA62834.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X06341; CAA29647.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M37766; AAA36211.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL121985; CAC00578.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC016182; AAH16182.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M63911; AAA35602.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00013831; -.
PIR A53244; A53244.
RefSeq NP_001769.2; -.
UniGene Hs.243564
3D structure databases
PDB
2EDO; NMR; -; A=27-140.[ExPASy / RCSB / EBI]
PDBsum 2EDO; -.
ModBase P09326.
Protein-protein interaction databases
IntAct P09326; 3.
Enzyme and pathway databases
Reactome REACT_604; Hemostasis.
REACT_6900; Signaling in Immune system.
Organism-specific databases
GeneCards GC01M158915; -.
H-InvDB HIX0001222; -.
HGNC HGNC:1683; CD48.
GenAtlas CD48.
HPA CAB002497; -.
MIM 109530; gene. [NCBI / EBI]
PharmGKB PA26223; -.
Gene expression databases
ArrayExpress P09326; -.
Bgee P09326; -.
CleanEx HS_CD48; -.
GermOnline ENSG00000117091; Homo sapiens.
Ontologies
GO
GO:0031225; Cellular component: anchored to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0045121; Cellular component: membrane raft (inferred from direct assay from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from UniProtKB).
GO:0006952; Biological process: defense response (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR015631; Signal_lymphocyte_activ_molc.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 1.
PANTHER PTHR12080; SLAM_related; 1.
SMART SM00409; IG; 1.
SMART graphical view of domain structure.
PROSITE PS50835; IG_LIKE; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PeptideAtlas P09326; -.
PRIDE P09326; -.
Genome annotation databases
Ensembl ENSG00000117091; Homo sapiens. [Contig view]
GeneID 962; -.
KEGG hsa:962; -.
Phylogenomic databases
HOGENOM P09326; -.
HOVERGEN P09326; -.
OMA P09326; PPCTLAR.
Other
NextBio 4020; -.
SOURCE CD48; Homo sapiens.
ProtoNet P09326.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cell membrane; Direct protein sequencing; Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain; Lipoprotein; Membrane; Polymorphism; Repeat; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    26  26     Potential. 
CHAIN   27   220  194     CD48 antigen. PRO_0000014881
PROPEP   221   243  23     Removed in mature form. PRO_0000014882
DOMAIN   29   127  99     Ig-like C2-type 1. 
DOMAIN   132   212  81     Ig-like C2-type 2. 
LIPID   220   220        GPI-anchor amidated serine. 
CARBOHYD   40    40        N-linked (GlcNAc...) (Potential). 
CARBOHYD   44    44        N-linked (GlcNAc...) (Potential). 
CARBOHYD   104   104        N-linked (GlcNAc...) (Potential). 
CARBOHYD   162   162        N-linked (GlcNAc...) (Potential). 
CARBOHYD   189   189        N-linked (GlcNAc...) (Potential). 
DISULFID   154   196        Potential. 
VARIANT   102   102  1     E -> Q (in dbSNP:rs2295615 [NCBI]). VAR_020082 
VARIANT   241   241  1     L -> S (in dbSNP:rs16832307 [NCBI]). VAR_049909 
CONFLICT   2     2        C -> W (in Ref. 1; AAA62834). 
CONFLICT   66    66        I -> N (in Ref. 3; CAA29647). 
STRAND   26    28  3      
STRAND   34    36  3      
STRAND   41    43  3      
STRAND   51    61  11      
STRAND   64    69  6      
STRAND   74    76  3      
TURN   80    84  5      
TURN   89    91  3      
STRAND   94    98  5      
HELIX   101   103  3      
STRAND   105   113  9      
TURN   114   116  3      
STRAND   117   120  4      
STRAND   126   128  3      
Sequence information
Length: 243 AA [This is the length of the unprocessed precursor] Molecular weight: 27683 Da [This is the MW of the unprocessed precursor] CRC64: 9E46D76FC36A512C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MCSRGWDSCL ALELLLLPLS LLVTSIQGHL VHMTVVSGSN VTLNISESLP ENYKQLTWFY 

        70         80         90        100        110        120 
TFDQKIVEWD SRKSKYFESK FKGRVRLDPQ SGALYISKVQ KEDNSTYIMR VLKKTGNEQE 

       130        140        150        160        170        180 
WKIKLQVLDP VPKPVIKIEK IEDMDDNCYL KLSCVIPGES VNYTWYGDKR PFPKELQNSV 

       190        200        210        220        230        240 
LETTLMPHNY SRCYTCQVSN SVSSKNGTVC LSPPCTLARS FGVEWIASWL VVTVPTILGL 


LLT 

P09326 in FASTA format

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