[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Platelet;
PubMed=2823383 [NCBI, ExPASy, EBI, Israel, Japan]
Kobilka B.K.,
Matsui H.,
Kobilka T.S.,
Yang-Feng T.L.,
Francke U.,
Caron M.G.,
Lefkowitz R.J.,
Regan J.W.;
"Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.";
Science 238:650-656(1987).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2568356 [NCBI, ExPASy, EBI, Israel, Japan]
Fraser C.M.,
Arakawa S.,
McCombie W.R.,
Venter J.C.;
"Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation.";
J. Biol. Chem. 264:11754-11761(1989).
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[3]
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SEQUENCE REVISION TO 333-365.
PubMed=2170371 [NCBI, ExPASy, EBI, Israel, Japan]
Guyer C.A.,
Horstman D.A.,
Wilson A.L.,
Clark J.D.,
Kragoe E.J. Jr.,
Limbird L.E.;
"Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs.";
J. Biol. Chem. 265:17307-17317(1990).
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[4]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LYS-251.
DOI=10.1074/jbc.M004550200; PubMed=10948191 [NCBI, ExPASy, EBI, Israel, Japan]
Small K.M.,
Forbes S.L.,
Brown K.M.,
Liggett S.B.;
"An Asn to Lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling.";
J. Biol. Chem. 275:38518-38523(2000).
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LYS-251.
DOI=10.1073/pnas.0601345103; PubMed=16567612 [NCBI, ExPASy, EBI, Israel, Japan]
Small K.M.,
Brown K.M.,
Seman C.A.,
Theiss C.T.,
Liggett S.B.;
"Complex haplotypes derived from noncoding polymorphisms of the intronless alpha-2A-adrenergic gene diversify receptor expression.";
Proc. Natl. Acad. Sci. U.S.A. 103:5472-5477(2006).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA].
Mao Z.-M.,
Tang K.,
Li B.-M.,
Jing N.-H.;
"Cloning and expression of human alpha-2A adrenergic receptor in SY5Y cells.";
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
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[7]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Castellano M.,
Giacche' M.,
Rossi F.,
Rivadossi F.,
Perani C.,
Beschi M.,
Agabiti Rosei E.;
"A search for genetic variability in the human alpha-2 adrenergic receptor on chromosome 10.";
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
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[8]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Liu L.,
Yuan L.;
"Human alpha-2A adrenergic receptor gene and the genotype of -1296 nucleotide and motionsickness.";
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
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[9]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LYS-251.
SeattleSNPs program for genomic applications;
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
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[10]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02462; PubMed=15164054 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P.,
Earthrowl M.E.,
Grafham D.V.,
Rubenfield M.,
French L.,
Steward C.A.,
Sims S.K.,
Jones M.C.,
Searle S.,
Scott C.,
Howe K.,
Hunt S.E.,
Andrews T.D.,
Gilbert J.G.R.,
Swarbreck D.,
Ashurst J.L.,
Taylor A.,
Battles J.,
Bird C.P., ![]()
Ainscough R.,
Almeida J.P.,
Ashwell R.I.S.,
Ambrose K.D.,
Babbage A.K.,
Bagguley C.L.,
Bailey J.,
Banerjee R.,
Bates K.,
Beasley H.,
Bray-Allen S.,
Brown A.J.,
Brown J.Y.,
Burford D.C.,
Burrill W.,
Burton J.,
Cahill P.,
Camire D.,
Carter N.P.,
Chapman J.C.,
Clark S.Y.,
Clarke G.,
Clee C.M.,
Clegg S.,
Corby N.,
Coulson A.,
Dhami P.,
Dutta I.,
Dunn M.,
Faulkner L.,
Frankish A.,
Frankland J.A.,
Garner P.,
Garnett J.,
Gribble S.,
Griffiths C.,
Grocock R.,
Gustafson E.,
Hammond S.,
Harley J.L.,
Hart E.,
Heath P.D.,
Ho T.P.,
Hopkins B.,
Horne J.,
Howden P.J.,
Huckle E.,
Hynds C.,
Johnson C.,
Johnson D.,
Kana A.,
Kay M.,
Kimberley A.M.,
Kershaw J.K.,
Kokkinaki M.,
Laird G.K.,
Lawlor S.,
Lee H.M.,
Leongamornlert D.A.,
Laird G.,
Lloyd C.,
Lloyd D.M.,
Loveland J.,
Lovell J.,
McLaren S.,
McLay K.E.,
McMurray A.,
Mashreghi-Mohammadi M.,
Matthews L.,
Milne S.,
Nickerson T.,
Nguyen M.,
Overton-Larty E.,
Palmer S.A.,
Pearce A.V.,
Peck A.I.,
Pelan S.,
Phillimore B.,
Porter K.,
Rice C.M.,
Rogosin A.,
Ross M.T.,
Sarafidou T.,
Sehra H.K.,
Shownkeen R.,
Skuce C.D.,
Smith M.,
Standring L.,
Sycamore N.,
Tester J.,
Thorpe A.,
Torcasso W.,
Tracey A.,
Tromans A.,
Tsolas J.,
Wall M.,
Walsh J.,
Wang H.,
Weinstock K.,
West A.P.,
Willey D.L.,
Whitehead S.L.,
Wilming L.,
Wray P.W.,
Young L.,
Chen Y.,
Lovering R.C.,
Moschonas N.K.,
Siebert R.,
Fechtel K.,
Bentley D.,
Durbin R.M.,
Hubbard T.,
Doucette-Stamm L.,
Beck S.,
Smith D.R.,
Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
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[11]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=PNS, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[12]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 77-209.
DOI=10.1016/0014-5793(91)80301-I; PubMed=1849485 [NCBI, ExPASy, EBI, Israel, Japan]
Chhajlani V.,
Rangel N.,
Uhlen S.,
Wikberg J.E.S.;
"Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR.";
FEBS Lett. 280:241-244(1991).
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[13]
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MUTAGENESIS OF PHE-412.
PubMed=1678390 [NCBI, ExPASy, EBI, Israel, Japan]
Suryanarayana S.,
Daunt D.A.,
von Zastrow M.,
Kobilka B.K.;
"A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists.";
J. Biol. Chem. 266:15488-15492(1991).
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[14]
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MUTAGENESIS OF ASPARTIC ACID AND SERINE RESIDUES.
PubMed=1678850 [NCBI, ExPASy, EBI, Israel, Japan]
Wang C.-D.,
Buck M.A.,
Fraser C.M.;
"Site-directed mutagenesis of alpha 2a-adrenergic receptors: Identification of amino acids involved in ligand binding and receptor activation by agonists.";
Mol. Pharmacol. 40:168-179(1991).
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[15]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297; SER-298 AND SER-299, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V.,
Blagoev B.,
Gnad F.,
Macek B.,
Kumar C.,
Mortensen P.,
Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
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[16]
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STRUCTURE BY NMR OF 118-149.
DOI=10.1021/bi015811+; PubMed=11888275 [NCBI, ExPASy, EBI, Israel, Japan]
Chung D.A.,
Zuiderweg E.R.,
Fowler C.B.,
Soyer O.S.,
Mosberg H.I.,
Neubig R.R.;
"NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix.";
Biochemistry 41:3596-3604(2002).
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