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UniProtKB/Swiss-Prot entry P08908


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 5HT1A_HUMAN
Primary accession number P08908
Secondary accession number Q6LAE7
Integrated into Swiss-Prot on November 1, 1988
Sequence was last modified on April 1, 1993 (Sequence version 3)
Annotations were last modified on    April 29, 2008 (Entry version 90)
Name and origin of the protein
Protein name 5-hydroxytryptamine receptor 1A
Synonyms 5-HT-1A
Serotonin receptor 1A
5-HT1A
G-21
Gene name
Name: HTR1A
Synonyms: ADRB2RL1, ADRBRL1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1038/329075a0; PubMed=3041227 [NCBI, ExPASy, EBI, Israel, Japan]
Kobilka B.K., Frielle T., Collins S., Yang-Feng T.L., Kobilka T.S., Francke U., Lefkowitz R.J., Caron M.G.;
"An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins.";
Nature 329:75-79(1987).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Saltzman A.G., Morse B., Felder S.;
Submitted (FEB-1991) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Kitano T., Kobayakawa H., Saitou N.;
"Silver project.";
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE OF 1-9.
DOI=10.1093/nar/19.25.7155; PubMed=1766875 [NCBI, ExPASy, EBI, Israel, Japan]
Parks C.L., Chang L.S., Shenk T.;
"A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region.";
Nucleic Acids Res. 19:7155-7160(1991).
[7]
NUCLEOTIDE SEQUENCE OF 200-365.
PubMed=8393041 [NCBI, ExPASy, EBI, Israel, Japan]
Aune T.M., McGrath K.M., Sarr T., Bombara M.P., Kelley K.A.;
"Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine.";
J. Immunol. 151:1175-1183(1993).
[8]
FUNCTION.
DOI=10.1038/335358a0; PubMed=3138543 [NCBI, ExPASy, EBI, Israel, Japan]
Fargin A., Raymond J.R., Lohse M.L., Kobilka B.K., Caron M.G., Lefkowitz R.J.;
"The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor.";
Nature 335:358-360(1988).
[9]
UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-334, AND MASS SPECTROMETRY.
TISSUE=Lung adenocarcinoma;
DOI=10.1021/pr060438j; PubMed=17203973 [NCBI, ExPASy, EBI, Israel, Japan]
Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.;
"The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells.";
J. Proteome Res. 6:298-305(2007).
[10]
VARIANTS SER-22 AND VAL-28.
DOI=10.1006/bbrc.1995.1692; PubMed=7755630 [NCBI, ExPASy, EBI, Israel, Japan]
Nakhai B., Nielsen D.A., Linnoila M., Goldman D.;
"Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28.";
Biochem. Biophys. Res. Commun. 210:530-536(1995).
[11]
VARIANTS LEU-16 AND ASP-273.
DOI=10.1002/(SICI)1096-8628(19980907)81:5<434::AID-AJMG13>3.0.CO;2-D; PubMed=9754630 [NCBI, ExPASy, EBI, Israel, Japan]
Kawanishi Y., Harada S., Tachikawa H., Okubo T., Shiraishi H.;
"Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia.";
Am. J. Med. Genet. 81:434-439(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M28269; AAA36440.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X13556; CAA31908.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X57829; CAA40962.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M83181; AAA66493.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB041403; BAA94488.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC069159; AAH69159.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF498978; AAM21125.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z11168; CAA77560.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I38209; I38209.
RefSeq NP_000515.2; -.
UniGene Hs.247940
3D structure databases
HSSP P08913; 1HLL. [HSSP ENTRY / PDB]
ModBase P08908.
Protein family/group databases
GPCRDB P08908; 5HT1A_HUMAN.
Organism-specific databases
H-InvDB HIX0032004; -.
HGNC HGNC:5286; HTR1A.
GeneLynx HTR1A; Homo sapiens.
GenAtlas HTR1A.
MIM 109760; gene. [NCBI / EBI]
PharmGKB PA192; -.
GeneCards P08908.
Gene expression databases
ArrayExpress P08908; -.
CleanEx HS_HTR1A; -.
GermOnline ENSG00000178394; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0004993; Molecular function: serotonin receptor activity (traceable author statement from ProtInc).
GO:0007610; Biological process: behavior (traceable author statement from ProtInc).
GO:0007186; Biological process: G-protein coupled receptor protein signaling pathway (traceable author statement from ProtInc).
GO:0008284; Biological process: positive regulation of cell proliferation (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR000610; 5HT1A_rcpt.
IPR002231; 5HT_rcpt.
IPR000276; GPCR_Rhodpsn.
Graphical view of domain structure.
PANTHER PTHR19266:SF64; 5HT1A_rcpt; 1.
Pfam PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00512; 5HT1ARECEPTR.
PR01101; 5HTRECEPTOR.
PR00237; GPCRRHODOPSN.
PROSITE PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P08908.
Genome annotation databases
Ensembl ENSG00000178394; Homo sapiens. [Contig view]
GeneID 3350; -.
KEGG hsa:3350; -.
Other
DrugBank DB00866; Alprenolol.
DB01238; Aripiprazole.
DB00490; Buspirone.
DB00363; Clozapine.
DB00216; Eletriptan.
DB01049; Ergoloid mesylate.
DB00176; Fluvoxamine.
DB00589; Lisuride.
DB00247; Methysergide.
DB00370; Mirtazapine.
DB00960; Pindolol.
DB00571; Propranolol.
DB01224; Quetiapine.
DB01104; Sertraline.
DB01079; Tegaserod.
DB00656; Trazodone.
DB00285; Venlafaxine.
DB00246; Ziprasidone.
SOURCE HTR1A; Homo sapiens.
GPCRDB-Snakes P08908.
ProtoNet P08908.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Transducer; Transmembrane; Ubl conjugation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   422  422     5-hydroxytryptamine receptor 1A. PRO_0000068903
TOPO_DOM   1    36  36     Extracellular (Potential). 
TRANSMEM   37    62  26     1 (Potential). 
TOPO_DOM   63    73  11     Cytoplasmic (Potential). 
TRANSMEM   74    98  25     2 (Potential). 
TOPO_DOM   99   109  11     Extracellular (Potential). 
TRANSMEM   110   132  23     3 (Potential). 
TOPO_DOM   133   152  20     Cytoplasmic (Potential). 
TRANSMEM   153   178  26     4 (Potential). 
TOPO_DOM   179   191  13     Extracellular (Potential). 
TRANSMEM   192   217  26     5 (Potential). 
TOPO_DOM   218   345  128     Cytoplasmic (Potential). 
TRANSMEM   346   367  22     6 (Potential). 
TOPO_DOM   368   378  11     Extracellular (Potential). 
TRANSMEM   379   403  25     7 (Potential). 
TOPO_DOM   404   422  19     Cytoplasmic (Potential). 
CARBOHYD   10    10        N-linked (GlcNAc...) (Potential). 
CARBOHYD   11    11        N-linked (GlcNAc...) (Potential). 
CARBOHYD   24    24        N-linked (GlcNAc...) (Potential). 
DISULFID   109   187        By similarity. 
CROSSLNK   334   334        Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin). 
VARIANT   16    16  1     P -> L (in dbSNP:rs1800041 [NCBI]). VAR_003446 
VARIANT   22    22  1     G -> S (in dbSNP:rs1799920 [NCBI]). VAR_011826 
VARIANT   28    28  1     I -> V (in dbSNP:rs1799921 [NCBI]). VAR_011827 
VARIANT   184   184  1     P -> L (in dbSNP:rs1800043 [NCBI]). VAR_011828 
VARIANT   220   220  1     R -> L (in dbSNP:rs1800044 [NCBI]). VAR_011829 
VARIANT   273   273  1     G -> D (in dbSNP:rs1800042 [NCBI]). VAR_011830 
CONFLICT   152   154        RAA -> PR (in Ref. 1; AAA36440/CAA31908). 
CONFLICT   172   172        M -> I (in Ref. 1; AAA36440/CAA31908). 
CONFLICT   200   202        TFG -> RPR (in Ref. 7). 
CONFLICT   228   228        K -> R (in Ref. 7). 
CONFLICT   244   244        A -> AA (in Ref. 7). 
CONFLICT   355   355        I -> T (in Ref. 7). 
CONFLICT   363   365        IVA -> MRP (in Ref. 7). 
CONFLICT   418   418        K -> N (in Ref. 1; AAA36440/CAA31908). 
Sequence information
Length: 422 AA [This is the length of the unprocessed precursor] Molecular weight: 46107 Da [This is the MW of the unprocessed precursor] CRC64: 762664FCF62CFD8F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA VLGNACVVAA 

        70         80         90        100        110        120 
IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC 

       130        140        150        160        170        180 
TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED 

       190        200        210        220        230        240 
RSDPDACTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT 

       250        260        270        280        290        300 
RHGASPAPQP KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN 

       310        320        330        340        350        360 
SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII MGTFILCWLP 

       370        380        390        400        410        420 
FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC 


RQ 

P08908 in FASTA format

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