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UniProtKB/Swiss-Prot entry P08670


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name VIME_HUMAN
Primary accession number P08670
Secondary accession numbers Q15867 Q15868 Q15869 Q548L2 Q6LER9 Q8N850 Q96ML2 Q9NTM3
Integrated into Swiss-Prot on January 1, 1988
Sequence was last modified on January 23, 2007 (Sequence version 4)
Annotations were last modified on    September 2, 2008 (Entry version 121)
Name and origin of the protein
Protein name Vimentin
Synonyms None
Gene name
Name: VIM
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3467175 [NCBI, ExPASy, EBI, Israel, Japan]
Ferrari S., Battini R., Kaczmarek L., Rittling S., Calabretta B., de Riel J.K., Philiponis V., Wei J.-F., Baserga R.;
"Coding sequence and growth regulation of the human vimentin gene.";
Mol. Cell. Biol. 6:3614-3620(1986).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1093/nar/18.22.6692; PubMed=2251132 [NCBI, ExPASy, EBI, Israel, Japan]
Honore B., Madsen P., Basse B., Andersen A., Walbum E., Celis J.E., Leffers H.;
"Nucleotide sequence of cDNA covering the complete coding part of the human vimentin gene.";
Nucleic Acids Res. 18:6692-6692(1990).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lymphoma;
DOI=10.1111/j.1365-2133.2004.05651.x; PubMed=14996095 [NCBI, ExPASy, EBI, Israel, Japan]
Hartmann T.B., Thiel D., Dummer R., Schadendorf D., Eichmueller S.;
"SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.";
Br. J. Dermatol. 150:252-258(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
Zimbelmann R.;
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo, Placenta, and Stomach;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Adipose tissue, and Coronary artery;
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02462; PubMed=15164054 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cervix, Placenta, and Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[11]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-135, AND TISSUE SPECIFICITY.
TISSUE=Mammary carcinoma;
PubMed=2472876 [NCBI, ExPASy, EBI, Israel, Japan]
Sommers C.L., Walker-Jones D., Heckford S.E., Worland P., Valverius E., Clark R., McCormick F., Stampfer M., Abularach S., Gelmann E.P.;
"Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogene-transformed mammary epithelial cells.";
Cancer Res. 49:4258-4263(1989).
[12]
PROTEIN SEQUENCE OF 2-11; 87-96; 129-138; 188-195; 223-234; 282-291; 322-333 AND 381-389, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, AND MASS SPECTROMETRY.
TISSUE=T-cell;
Bienvenut W.V., Kanor S., Tissot J.-D., Quadroni M.;
Submitted (MAY-2006) to UniProtKB.
[13]
PROTEIN SEQUENCE OF 17-25 AND 55-70.
TISSUE=Mammary carcinoma;
PubMed=9150946 [NCBI, ExPASy, EBI, Israel, Japan]
Rasmussen R.K., Ji H., Eddes J.S., Moritz R.L., Reid G.E., Simpson R.J., Dorow D.S.;
"Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.";
Electrophoresis 18:588-598(1997).
[14]
PROTEIN SEQUENCE OF 79-97 AND 411-424, AND MASS SPECTROMETRY.
TISSUE=Brain, and Cajal-Retzius cell;
Lubec G., Vishwanath V.;
Submitted (MAR-2007) to UniProtKB.
[15]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 113-466, AND TISSUE SPECIFICITY.
TISSUE=Fibroblast;
DOI=10.1016/0378-1119(88)90575-6; PubMed=3371665 [NCBI, ExPASy, EBI, Israel, Japan]
Perreau J., Lilienbaum A., Vasseur M., Paulin D.;
"Nucleotide sequence of the human vimentin gene and regulation of its transcription in tissues and cultured cells.";
Gene 62:7-16(1988).
[16]
NUCLEOTIDE SEQUENCE [MRNA] OF 167-466.
TISSUE=Osteosarcoma;
DOI=10.1016/0378-1119(90)90295-3; PubMed=2323579 [NCBI, ExPASy, EBI, Israel, Japan]
Gupta A.K., Aubin J.E., Waye M.M.Y.;
"Isolation of a human vimentin cDNA with a long 3'-noncoding region from a human osteosarcoma cell line (MG-63).";
Gene 86:303-304(1990).
[17]
PHOSPHORYLATION AT SER-5; SER-7; SER-8; SER-9; SER-10; SER-39; SER-42; SER-72; SER-73; SER-420; SER-430; THR-458 AND SER-459, AND MASS SPECTROMETRY.
DOI=10.1242/jcs.00906; PubMed=14762106 [NCBI, ExPASy, EBI, Israel, Japan]
Eriksson J.E., He T., Trejo-Skalli A.V., Harmala-Brasken A.-S., Hellman J., Chou Y.-H., Goldman R.D.;
"Specific in vivo phosphorylation sites determine the assembly dynamics of vimentin intermediate filaments.";
J. Cell Sci. 117:919-932(2004).
[18]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-117, AND MASS SPECTROMETRY.
DOI=10.1038/nbt1046; PubMed=15592455 [NCBI, ExPASy, EBI, Israel, Japan]
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.;
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
Nat. Biotechnol. 23:94-101(2005).
[19]
INTERACTION WITH HCV CORE PROTEIN.
DOI=10.1002/pmic.200401093; PubMed=15846844 [NCBI, ExPASy, EBI, Israel, Japan]
Kang S.-M., Shin M.-J., Kim J.-H., Oh J.-W.;
"Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein.";
Proteomics 5:2227-2237(2005).
[20]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27; SER-56; SER-73; SER-214 AND SER-412, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
[21]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1038/nbt1240; PubMed=16964243 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[22]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0507066103; PubMed=16565220 [NCBI, ExPASy, EBI, Israel, Japan]
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
"Phosphoproteome analysis of the human mitotic spindle.";
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
[23]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-38; TYR-53; TYR-61 AND TYR-117, AND MASS SPECTROMETRY.
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
[24]
IDENTIFICATION IN A COMPLEX WITH ACTB; AP2M1; AP2A1; AP2A2 AND MEGF10.
DOI=10.1016/j.yexcr.2007.06.015; PubMed=17643423 [NCBI, ExPASy, EBI, Israel, Japan]
Suzuki E., Nakayama M.;
"MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation.";
Exp. Cell Res. 313:3729-3742(2007).
[25]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56; SER-412; THR-446 AND SER-459, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1021/pr070152u; PubMed=17924679 [NCBI, ExPASy, EBI, Israel, Japan]
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
J. Proteome Res. 6:4150-4162(2007).
[26]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-39; SER-47; SER-55; SER-56; TYR-61; SER-430; THR-458 AND SER-459, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0611217104; PubMed=17287340 [NCBI, ExPASy, EBI, Israel, Japan]
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.";
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
[27]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51 AND SER-412, AND MASS SPECTROMETRY.
DOI=10.1021/pr0705441; PubMed=18220336 [NCBI, ExPASy, EBI, Israel, Japan]
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
[28]
X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 102-138.
DOI=10.1006/jmbi.2001.4442; PubMed=11243787 [NCBI, ExPASy, EBI, Israel, Japan]
Strelkov S.V., Herrmann H., Geisler N., Lustig A., Ivaninskii S., Zimbelmann R., Burkhard P., Aebi U.;
"Divide-and-conquer crystallographic approach towards an atomic structure of intermediate filaments.";
J. Mol. Biol. 306:773-781(2001).
[29]
X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 103-139 AND 328-411.
DOI=10.1093/emboj/21.6.1255; PubMed=11889032 [NCBI, ExPASy, EBI, Israel, Japan]
Strelkov S.V., Herrmann H., Geisler N., Wedig T., Zimbelmann R., Aebi U., Burkhard P.;
"Conserved segments 1A and 2B of the intermediate filament dimer: their atomic structures and role in filament assembly.";
EMBO J. 21:1255-1266(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M14144; AAA61279.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X56134; CAA39600.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF328728; AAN09720.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z19554; CAA79613.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK056766; BAB71275.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK097336; BAC05002.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK290643; BAF83332.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CR407690; CAG28618.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK222507; BAD96227.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK222602; BAD96322.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL133415; CAB87963.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471072; EAW86215.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000163; AAH00163.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC030573; AAH30573.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC066956; AAH66956.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X16478; CAA34499.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18895; AAA61281.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18888; AAA61281.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18889; AAA61281.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18890; AAA61281.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18891; AAA61281.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18892; AAA61281.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18893; AAA61281.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M18894; AAA61281.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M25246; AAA61282.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S13115; A25074.
RefSeq NP_003371.2; -.
UniGene Hs.642813
3D structure databases
PDB
1GK4; X-ray; 2.30 A; A/B/C/D/E/F=328-411.[ExPASy / RCSB / EBI]
1GK6; X-ray; 1.90 A; A/B=385-412.[ExPASy / RCSB / EBI]
1GK7; X-ray; 1.40 A; A=102-138.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1GK4; -.
1GK6; -.
1GK7; -.
ModBase P08670.
Protein-protein interaction databases
IntAct P08670; -.
PTM databases
PhosphoSite P08670; -.
2D gel databases
SWISS-2DPAGE P08670; -.
Aarhus/Ghent-2DPAGE 8417; IEF.
Cornea-2DPAGE P08670; -.
DOSAC-COBS-2DPAGE P08670; -.
HSC-2DPAGE P08670; -.
OGP P08670; -.
PHCI-2DPAGE P08670; -.
REPRODUCTION-2DPAGE IPI00418471; -.
P08670; -.
Organism-specific databases
H-InvDB HIX0008682; -.
HIX0035657; -.
HGNC HGNC:12692; VIM.
GenAtlas VIM.
HPA CAB000080; -.
HPA001762; -.
MIM 193060; gene. [NCBI / EBI]
PharmGKB PA37311; -.
GeneCards P08670.
Gene expression databases
ArrayExpress P08670; -.
GermOnline ENSG00000026025; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from UniProtKB).
GO:0005882; Cellular component: intermediate filament (inferred from direct assay from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from direct assay from UniProtKB).
GO:0005200; Molecular function: structural constituent of cytoskeleton (inferred from direct assay from UniProtKB).
GO:0006928; Biological process: cell motion (traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR016044; F.
IPR001664; IF.
IPR006821; Intermed_filament_DNA_bd.
Graphical view of domain structure.
PANTHER PTHR23239; IF; 1.
Pfam PF00038; Filament; 1.
PF04732; Filament_head; 1.
Pfam graphical view of domain structure.
PROSITE PS00226; IF; 1.
BLOCKS P08670.
Proteomic databases
PeptideAtlas P08670; -.
Genome annotation databases
Ensembl ENSG00000026025; Homo sapiens. [Contig view]
GeneID 7431; -.
KEGG hsa:7431; -.
Phylogenomic databases
HOVERGEN P08670; -.
Other
LinkHub P08670; -.
SOURCE VIM; Homo sapiens.
ProtoNet P08670.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Acetylation; Coiled coil; Direct protein sequencing; Host-virus interaction; Intermediate filament; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   466  465     Vimentin. PRO_0000063754
REGION   2    95  94     Head. 
REGION   96   407  312     Rod. 
REGION   96   131  36     Coil 1A. 
REGION   132   153  22     Linker 1. 
REGION   154   245  92     Coil 1B. 
REGION   246   268  23     Linker 12. 
REGION   269   407  139     Coil 2. 
REGION   408   466  59     Tail. 
MOD_RES   2     2        N-acetylserine. 
MOD_RES   5     5        Phosphoserine. 
MOD_RES   7     7        Phosphoserine; by PKA and PKC. 
MOD_RES   8     8        Phosphoserine. 
MOD_RES   9     9        Phosphoserine; by PKC. 
MOD_RES   10    10        Phosphoserine; by PKC. 
MOD_RES   25    25        Phosphoserine; by PKA and PKC (By similarity). 
MOD_RES   26    26        Phosphoserine; by PKC (By similarity). 
MOD_RES   27    27        Phosphoserine. 
MOD_RES   34    34        Phosphoserine; by PKC (By similarity). 
MOD_RES   38    38        Phosphotyrosine. 
MOD_RES   39    39        Phosphoserine; by CaMK2, PKA and PKC. 
MOD_RES   42    42        Phosphoserine; by PKC. 
MOD_RES   47    47        Phosphoserine. 
MOD_RES   51    51        Phosphoserine; by PKA and PKC (By similarity). 
MOD_RES   53    53        Phosphotyrosine.