[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM P60-HCK).
PubMed=3496523 [NCBI, ExPASy, EBI, Israel, Japan]
Quintrell N.,
Lebo R.,
Varmus H.,
Bishop J.M.,
Pettenati M.J.,
le Beau M.M.,
Diaz M.O.,
Rowley J.D.;
"Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.";
Mol. Cell. Biol. 7:2267-2275(1987).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM P59-HCK).
PubMed=3453117 [NCBI, ExPASy, EBI, Israel, Japan]
Ziegler S.F.,
Marth J.D.,
Lewis D.B.,
Perlmutter R.M.;
"Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin.";
Mol. Cell. Biol. 7:2276-2285(1987).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM P60-HCK).
TISSUE=Ileal mucosa;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T.,
Suzuki Y.,
Nishikawa T.,
Otsuki T.,
Sugiyama T.,
Irie R.,
Wakamatsu A.,
Hayashi K.,
Sato H.,
Nagai K.,
Kimura K.,
Makita H.,
Sekine M.,
Obayashi M.,
Nishi T.,
Shibahara T.,
Tanaka T.,
Ishii S.,
Yamamoto J., ![]()
Saito K.,
Kawai Y.,
Isono Y.,
Nakamura Y.,
Nagahari K.,
Murakami K.,
Yasuda T.,
Iwayanagi T.,
Wagatsuma M.,
Shiratori A.,
Sudo H.,
Hosoiri T.,
Kaku Y.,
Kodaira H.,
Kondo H.,
Sugawara M.,
Takahashi M.,
Kanda K.,
Yokoi T.,
Furuya T.,
Kikkawa E.,
Omura Y.,
Abe K.,
Kamihara K.,
Katsuta N.,
Sato K.,
Tanikawa M.,
Yamazaki M.,
Ninomiya K.,
Ishibashi T.,
Yamashita H.,
Murakawa K.,
Fujimori K.,
Tanai H.,
Kimata M.,
Watanabe M.,
Hiraoka S.,
Chiba Y.,
Ishida S.,
Ono Y.,
Takiguchi S.,
Watanabe S.,
Yosida M.,
Hotuta T.,
Kusano J.,
Kanehori K.,
Takahashi-Fujii A.,
Hara H.,
Tanase T.-O.,
Nomura Y.,
Togiya S.,
Komai F.,
Hara R.,
Takeuchi K.,
Arita M.,
Imose N.,
Musashino K.,
Yuuki H.,
Oshima A.,
Sasaki N.,
Aotsuka S.,
Yoshikawa Y.,
Matsunawa H.,
Ichihara T.,
Shiohata N.,
Sano S.,
Moriya S.,
Momiyama H.,
Satoh N.,
Takami S.,
Terashima Y.,
Suzuki O.,
Nakagawa S.,
Senoh A.,
Mizoguchi H.,
Goto Y.,
Shimizu F.,
Wakebe H.,
Hishigaki H.,
Watanabe T.,
Sugiyama A.,
Takemoto M.,
Kawakami B.,
Yamazaki M.,
Watanabe K.,
Kumagai A.,
Itakura S.,
Fukuzumi Y.,
Fujimori Y.,
Komiyama M.,
Tashiro H.,
Tanigami A.,
Fujiwara T.,
Ono T.,
Yamada K.,
Fujii Y.,
Ozaki K.,
Hirao M.,
Ohmori Y.,
Kawabata A.,
Hikiji T.,
Kobatake N.,
Inagaki H.,
Ikema Y.,
Okamoto S.,
Okitani R.,
Kawakami T.,
Noguchi S.,
Itoh T.,
Shigeta K.,
Senba T.,
Matsumura K.,
Nakajima Y.,
Mizuno T.,
Morinaga M.,
Sasaki M.,
Togashi T.,
Oyama M.,
Hata H.,
Watanabe M.,
Komatsu T.,
Mizushima-Sugano J.,
Satoh T.,
Shirai Y.,
Takahashi Y.,
Nakagawa K.,
Okumura K.,
Nagase T.,
Nomura N.,
Kikuchi H.,
Masuho Y.,
Yamashita R.,
Nakai K.,
Yada T.,
Nakamura Y.,
Ohara O.,
Isogai T.,
Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/414865a; PubMed=11780052 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P.,
Matthews L.H.,
Ashurst J.L.,
Burton J.,
Gilbert J.G.R.,
Jones M.,
Stavrides G.,
Almeida J.P.,
Babbage A.K.,
Bagguley C.L.,
Bailey J.,
Barlow K.F.,
Bates K.N.,
Beard L.M.,
Beare D.M.,
Beasley O.P.,
Bird C.P.,
Blakey S.E.,
Bridgeman A.M., ![]()
Brown A.J.,
Buck D.,
Burrill W.D.,
Butler A.P.,
Carder C.,
Carter N.P.,
Chapman J.C.,
Clamp M.,
Clark G.,
Clark L.N.,
Clark S.Y.,
Clee C.M.,
Clegg S.,
Cobley V.E.,
Collier R.E.,
Connor R.E.,
Corby N.R.,
Coulson A.,
Coville G.J.,
Deadman R.,
Dhami P.D.,
Dunn M.,
Ellington A.G.,
Frankland J.A.,
Fraser A.,
French L.,
Garner P.,
Grafham D.V.,
Griffiths C.,
Griffiths M.N.D.,
Gwilliam R.,
Hall R.E.,
Hammond S.,
Harley J.L.,
Heath P.D.,
Ho S.,
Holden J.L.,
Howden P.J.,
Huckle E.,
Hunt A.R.,
Hunt S.E.,
Jekosch K.,
Johnson C.M.,
Johnson D.,
Kay M.P.,
Kimberley A.M.,
King A.,
Knights A.,
Laird G.K.,
Lawlor S.,
Lehvaeslaiho M.H.,
Leversha M.A.,
Lloyd C.,
Lloyd D.M.,
Lovell J.D.,
Marsh V.L.,
Martin S.L.,
McConnachie L.J.,
McLay K.,
McMurray A.A.,
Milne S.A.,
Mistry D.,
Moore M.J.F.,
Mullikin J.C.,
Nickerson T.,
Oliver K.,
Parker A.,
Patel R.,
Pearce T.A.V.,
Peck A.I.,
Phillimore B.J.C.T.,
Prathalingam S.R.,
Plumb R.W.,
Ramsay H.,
Rice C.M.,
Ross M.T.,
Scott C.E.,
Sehra H.K.,
Shownkeen R.,
Sims S.,
Skuce C.D.,
Smith M.L.,
Soderlund C.,
Steward C.A.,
Sulston J.E.,
Swann R.M.,
Sycamore N.,
Taylor R.,
Tee L.,
Thomas D.W.,
Thorpe A.,
Tracey A.,
Tromans A.C.,
Vaudin M.,
Wall M.,
Wallis J.M.,
Whitehead S.L.,
Whittaker P.,
Willey D.L.,
Williams L.,
Williams S.A.,
Wilming L.,
Wray P.W.,
Hubbard T.,
Durbin R.M.,
Bentley D.R.,
Beck S.,
Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM P60-HCK).
TISSUE=B-cell, and Lymph;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1-21 (ISOFORM P60-HCK), AND ALTERNATIVE INITIATION.
TISSUE=Bone marrow;
PubMed=1875927 [NCBI, ExPASy, EBI, Israel, Japan]
Lock P.,
Ralph S.,
Stanley E.,
Boulet I.,
Ramsay R.,
Dunn A.R.;
"Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization.";
Mol. Cell. Biol. 11:4363-4370(1991).
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[7]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 178-526.
TISSUE=Spleen;
DOI=10.1016/0378-1119(92)90407-G; PubMed=1572549 [NCBI, ExPASy, EBI, Israel, Japan]
Hradetzky D.,
Strebhardt K.,
Ruesamen-Waigmann H.;
"The genomic locus of the human hemopoietic-specific cell protein tyrosine kinase (PTK)-encoding gene (HCK) confirms conservation of exon-intron structure among human PTKs of the src family.";
Gene 113:275-280(1992).
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[8]
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INTERACTION WITH HIV-1 NEF.
DOI=10.1074/jbc.272.29.17899; PubMed=9218412 [NCBI, ExPASy, EBI, Israel, Japan]
Briggs S.D.,
Sharkey M.,
Stevenson M.,
Smithgall T.E.;
"SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.";
J. Biol. Chem. 272:17899-17902(1997).
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[9]
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INTERACTION WITH HIV-1 VIF.
DOI=10.1074/jbc.M009076200; PubMed=11278465 [NCBI, ExPASy, EBI, Israel, Japan]
Hassaine G.,
Courcoul M.,
Bessou G.,
Barthalay Y.,
Picard C.,
Olive D.,
Collette Y.,
Vigne R.,
Decroly E.;
"The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein.";
J. Biol. Chem. 276:16885-16893(2001).
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[10]
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INTERACTION WITH HEV ORF3 PROTEIN.
DOI=10.1074/jbc.M101546200; PubMed=11518702 [NCBI, ExPASy, EBI, Israel, Japan]
Korkaya H.,
Jameel S.,
Gupta D.,
Tyagi S.,
Kumar R.,
Zafrullah M.,
Mazumdar M.,
Lal S.K.,
Xiaofang L.,
Sehgal D.,
Das S.R.,
Sahal D.;
"The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.";
J. Biol. Chem. 276:42389-42400(2001).
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[11]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-411, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V.,
Blagoev B.,
Gnad F.,
Macek B.,
Kumar C.,
Mortensen P.,
Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
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[12]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-209, AND MASS SPECTROMETRY.
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K.,
Guo A.,
Zeng Q.,
Possemato A.,
Yu J.,
Haack H.,
Nardone J.,
Lee K.,
Reeves C.,
Li Y.,
Hu Y.,
Tan Z.,
Stokes M.,
Sullivan L.,
Mitchell J.,
Wetzel R.,
Macneill J.,
Ren J.M.,
Yuan J., ![]()
Bakalarski C.E.,
Villen J.,
Kornhauser J.M.,
Smith B.,
Li D.,
Zhou X.,
Gygi S.P.,
Gu T.-L.,
Polakiewicz R.D.,
Rush J.,
Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
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[13]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-411, AND MASS SPECTROMETRY.
TISSUE=Platelet;
DOI=10.1021/pr0704130; PubMed=18088087 [NCBI, ExPASy, EBI, Israel, Japan]
Zahedi R.P.,
Lewandrowski U.,
Wiesner J.,
Wortelkamp S.,
Moebius J.,
Schuetz C.,
Walter U.,
Gambaryan S.,
Sickmann A.;
"Phosphoproteome of resting human platelets.";
J. Proteome Res. 7:526-534(2008).
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[14]
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X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 78-526.
DOI=10.1038/385602a0; PubMed=9024658 [NCBI, ExPASy, EBI, Israel, Japan]
Sicheri F.,
Moarefi I.,
Kuriyan J.;
"Crystal structure of the Src family tyrosine kinase Hck.";
Nature 385:602-609(1997).
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[15]
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X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 81-137.
DOI=10.1021/bi980989q; PubMed=9778343 [NCBI, ExPASy, EBI, Israel, Japan]
Arold S.,
O'Brien R.,
Franken P.,
Strub M.-P.,
Hoh F.,
Dumas C.,
Ladbury J.E.;
"RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef.";
Biochemistry 37:14683-14691(1998).
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[16]
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STRUCTURE BY NMR OF 78-138.
DOI=10.1006/jmbi.1998.1690; PubMed=9571048 [NCBI, ExPASy, EBI, Israel, Japan]
Horita D.A.,
Baldisseri D.M.,
Zhang W.,
Altieri A.S.,
Smithgall T.E.,
Gmeiner W.H.,
Byrd R.A.;
"Solution structure of the human Hck SH3 domain and identification of its ligand binding site.";
J. Mol. Biol. 278:253-265(1998).
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[17]
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STRUCTURE BY NMR OF 139-245.
DOI=10.1016/S0014-5793(97)00255-X; PubMed=9109402 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang W.,
Smithgall T.E.,
Gmeiner W.H.;
"Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase.";
FEBS Lett. 406:131-135(1997).
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[18]
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VARIANTS [LARGE SCALE ANALYSIS] THR-44; LEU-105 AND GLY-399.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
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