[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
PubMed=2819873 [NCBI, ExPASy, EBI, Israel, Japan]
Park M.,
Dean M.,
Kaul K.,
Braun M.J.,
Gonda M.A.,
Vande Woude G.;
"Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.";
Proc. Natl. Acad. Sci. U.S.A. 84:6379-6383(1987).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Giordano S.;
Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01782; PubMed=12853948 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W.,
Fulton R.S.,
Fulton L.A.,
Graves T.A.,
Pepin K.H.,
Wagner-McPherson C.,
Layman D.,
Maas J.,
Jaeger S.,
Walker R.,
Wylie K.,
Sekhon M.,
Becker M.C.,
O'Laughlin M.D.,
Schaller M.E.,
Fewell G.A.,
Delehaunty K.D.,
Miner T.L.,
Nash W.E., ![]()
Cordes M.,
Du H.,
Sun H.,
Edwards J.,
Bradshaw-Cordum H.,
Ali J.,
Andrews S.,
Isak A.,
Vanbrunt A.,
Nguyen C.,
Du F.,
Lamar B.,
Courtney L.,
Kalicki J.,
Ozersky P.,
Bielicki L.,
Scott K.,
Holmes A.,
Harkins R.,
Harris A.,
Strong C.M.,
Hou S.,
Tomlinson C.,
Dauphin-Kohlberg S.,
Kozlowicz-Reilly A.,
Leonard S.,
Rohlfing T.,
Rock S.M.,
Tin-Wollam A.-M.,
Abbott A.,
Minx P.,
Maupin R.,
Strowmatt C.,
Latreille P.,
Miller N.,
Johnson D.,
Murray J.,
Woessner J.P.,
Wendl M.C.,
Yang S.-P.,
Schultz B.R.,
Wallis J.W.,
Spieth J.,
Bieri T.A.,
Nelson J.O.,
Berkowicz N.,
Wohldmann P.E.,
Cook L.L.,
Hickenbotham M.T.,
Eldred J.,
Williams D.,
Bedell J.A.,
Mardis E.R.,
Clifton S.W.,
Chissoe S.L.,
Marra M.A.,
Raymond C.,
Haugen E.,
Gillett W.,
Zhou Y.,
James R.,
Phelps K.,
Iadanoto S.,
Bubb K.,
Simms E.,
Levy R.,
Clendenning J.,
Kaul R.,
Kent W.J.,
Furey T.S.,
Baertsch R.A.,
Brent M.R.,
Keibler E.,
Flicek P.,
Bork P.,
Suyama M.,
Bailey J.A.,
Portnoy M.E.,
Torrents D.,
Chinwalla A.T.,
Gish W.R.,
Eddy S.R.,
McPherson J.D.,
Olson M.V.,
Eichler E.E.,
Green E.D.,
Waterston R.H.,
Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1010-1390.
PubMed=3325883 [NCBI, ExPASy, EBI, Israel, Japan]
Chan A.M.-L.,
King H.W.S.,
Tempest P.R.,
Deakin E.A.,
Cooper C.S.,
Brookes P.;
"Primary structure of the met protein tyrosine kinase domain.";
Oncogene 1:229-233(1987).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1206-1264.
PubMed=8247543 [NCBI, ExPASy, EBI, Israel, Japan]
Lee S.-T.,
Strunk K.M.,
Spritz R.A.;
"A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.";
Oncogene 8:3403-3410(1993).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA] OF 1267-1390.
DOI=10.1038/318385a0; PubMed=4069211 [NCBI, ExPASy, EBI, Israel, Japan]
Dean M.,
Park M.,
le Beau M.M.,
Robins T.S.,
Diaz M.O.,
Rowley J.D.,
Blair D.G.,
Vande Woude G.F.;
"The human met oncogene is related to the tyrosine kinase oncogenes.";
Nature 318:385-388(1985).
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[7]
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FUNCTION.
PubMed=1846706 [NCBI, ExPASy, EBI, Israel, Japan]
Bottaro D.P.,
Rubin J.S.,
Faletto D.L.,
Chan A.M.-L.,
Kmiecik T.E.,
Vande Woude G.F.,
Aaronson S.A.;
"Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.";
Science 251:802-804(1991).
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[8]
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PHOSPHORYLATION AT TYR-1235, AND ATP-BINDING SITE LYS-1110.
PubMed=1655790 [NCBI, ExPASy, EBI, Israel, Japan]
Ferracini R.,
Longati P.,
Naldini L.,
Vigna E.,
Comoglio P.M.;
"Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase.";
J. Biol. Chem. 266:19558-19564(1991).
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[9]
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INTERACTION WITH RANBP9.
DOI=10.1074/jbc.M205111200; PubMed=12147692 [NCBI, ExPASy, EBI, Israel, Japan]
Wang D.,
Li Z.,
Messing E.M.,
Wu G.;
"Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM.";
J. Biol. Chem. 277:36216-36222(2002).
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[10]
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INTERACTION WITH PLXNB1.
DOI=10.1038/ncb843; PubMed=12198496 [NCBI, ExPASy, EBI, Israel, Japan]
Giordano S.,
Corso S.,
Conrotto P.,
Artigiani S.,
Gilestro G.,
Barberis D.,
Tamagnone L.,
Comoglio P.M.;
"The semaphorin 4D receptor controls invasive growth by coupling with Met.";
Nat. Cell Biol. 4:720-724(2002).
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[11]
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INTERACTION WITH RANBP9 AND RANBP10.
DOI=10.1016/j.bbrc.2003.11.124; PubMed=14684163 [NCBI, ExPASy, EBI, Israel, Japan]
Wang D.,
Li Z.,
Schoen S.R.,
Messing E.M.,
Wu G.;
"A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling.";
Biochem. Biophys. Res. Commun. 313:320-326(2004).
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[12]
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PHOSPHORYLATION AT TYR-1356, AND INTERACTION WITH INPPL1.
DOI=10.1038/sj.onc.1208558; PubMed=15735664 [NCBI, ExPASy, EBI, Israel, Japan]
Koch A.,
Mancini A.,
El Bounkari O.,
Tamura T.;
"The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading.";
Oncogene 24:3436-3447(2005).
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[13]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1003; TYR-1230; TYR-1234 AND TYR-1235, AND MASS SPECTROMETRY.
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K.,
Guo A.,
Zeng Q.,
Possemato A.,
Yu J.,
Haack H.,
Nardone J.,
Lee K.,
Reeves C.,
Li Y.,
Hu Y.,
Tan Z.,
Stokes M.,
Sullivan L.,
Mitchell J.,
Wetzel R.,
Macneill J.,
Ren J.M.,
Yuan J., ![]()
Bakalarski C.E.,
Villen J.,
Kornhauser J.M.,
Smith B.,
Li D.,
Zhou X.,
Gygi S.P.,
Gu T.-L.,
Polakiewicz R.D.,
Rush J.,
Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
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[14]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-977; SER-988; SER-990 AND TYR-1003, AND MASS SPECTROMETRY.
DOI=10.1074/mcp.T600062-MCP200; PubMed=17192257 [NCBI, ExPASy, EBI, Israel, Japan]
Wissing J.,
Jaensch L.,
Nimtz M.,
Dieterich G.,
Hornberger R.,
Keri G.,
Wehland J.,
Daub H.;
"Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.";
Mol. Cell. Proteomics 6:537-547(2007).
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[15]
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X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1356-1359 IN COMPLEX WITH GRB2.
DOI=10.1021/bi0012336; PubMed=11063574 [NCBI, ExPASy, EBI, Israel, Japan]
Schiering N.,
Casale E.,
Caccia P.,
Giordano P.,
Battistini C.;
"Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex.";
Biochemistry 39:13376-13382(2000).
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[16]
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X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1049-1360 IN COMPLEX WITH INHIBITOR.
DOI=10.1073/pnas.1734128100; PubMed=14559966 [NCBI, ExPASy, EBI, Israel, Japan]
Schiering N.,
Knapp S.,
Marconi M.,
Flocco M.M.,
Cui J.,
Perego R.,
Rusconi L.,
Cristiani C.;
"Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a.";
Proc. Natl. Acad. Sci. U.S.A. 100:12654-12659(2003).
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[17]
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VARIANTS HPRC THR-1131; LEU-1188; VAL-1195; ILE-1220; HIS-1228; ASN-1228; CYS-1230; HIS-1230 AND THR-1250, AND VARIANT VAL-320.
DOI=10.1038/ng0597-68; PubMed=9140397 [NCBI, ExPASy, EBI, Israel, Japan]
Schmidt L.,
Duh F.-M.,
Chen F.,
Kishida T.,
Glenn G.,
Choyke P.,
Scherer S.W.,
Zhuang Z.,
Lubensky I.,
Dean M.,
Allikmets R.,
Chidambaram A.,
Bergerheim U.R.,
Feltis J.T.,
Casadevall C.,
Zamarron A.,
Bernues M.,
Richard S.,
Lips C.J.M., ![]()
Walther M.M.,
Tsui L.-C.,
Geil L.,
Orcutt M.L.,
Stackhouse T.,
Lipan J.,
Slife L.,
Brauch H.,
Decker J.,
Niehans G.,
Hughson M.D.,
Moch H.,
Storkel S.,
Lerman M.I.,
Linehan W.M.,
Zbar B.;
"Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas.";
Nat. Genet. 16:68-73(1997).
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[18]
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VARIANT HPRC ARG-1094, AND CHARACTERIZATION OF VARIANT HPRC ARG-1094.
PubMed=9563489 [NCBI, ExPASy, EBI, Israel, Japan]
Schmidt L.,
Junker K.,
Weirich G.,
Glenn G.,
Choyke P.,
Lubensky I.,
Zhuang Z.,
Jeffers M.,
Vande Woude G.,
Neumann H.,
Walther M.,
Linehan W.M.,
Zbar B.;
"Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene.";
Cancer Res. 58:1719-1722(1998).
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[19]
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VARIANTS HPRC ILE-1092; ARG-1094; ASP-1106; THR-1131; LEU-1188; ASP-1230; CYS-1230 AND THR-1250.
PubMed=10433944 [NCBI, ExPASy, EBI, Israel, Japan]
Lubensky I.A.,
Schmidt L.,
Zhuang Z.,
Weirich G.,
Pack S.,
Zambrano N.,
Walther M.M.,
Choyke P.,
Linehan W.M.,
Zbar B.;
"Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype.";
Am. J. Pathol. 155:517-526(1999).
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[20]
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VARIANTS HCC ILE-1173; ARG-1244 AND ILE-1250.
PubMed=9927037 [NCBI, ExPASy, EBI, Israel, Japan]
Park W.S.,
Dong S.M.,
Kim S.Y.,
Na E.Y.,
Shin M.S.,
Pi J.H.,
Kim B.J.,
Bae J.H.,
Hong Y.K.,
Lee K.S.,
Lee S.H.,
Yoo N.J.,
Jang J.J.,
Pack S.,
Zhuang Z.,
Schmidt L.,
Zbar B.,
Lee J.Y.;
"Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas.";
Cancer Res. 59:307-310(1999).
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[21]
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VARIANT HPRC ILE-1092, AND CHARACTERIZATION OF VARIANT HPRC ILE-1092.
DOI=10.1002/(SICI)1097-0215(19990827)82:5<640::AID-IJC4>3.0.CO;2-6; PubMed=10417759 [NCBI, ExPASy, EBI, Israel, Japan]
Olivero M.,
Valente G.,
Bardelli A.,
Longati P.,
Ferrero N.,
Cracco C.,
Terrone C.,
Rocca-Rossetti S.,
Comoglio P.M.,
Di Renzo M.F.;
"Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinase in a HPRCC family.";
Int. J. Cancer 82:640-643(1999).
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[22]
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VARIANTS HPRC ILE-1092; LEU-1094; TYR-1094; ASP-1106 AND ASP-1230, AND CHARACTERIZATION OF VARIANTS HPRC ILE-1092; LEU-1094; TYR-1094; ASP-1106 AND ASP-1230.
DOI=10.1038/sj.onc.1202547; PubMed=10327054 [NCBI, ExPASy, EBI, Israel, Japan]
Schmidt L.,
Junker K.,
Nakaigawa N.,
Kinjerski T.,
Weirich G.,
Miller M.,
Lubensky I.,
Neumann H.P.H.,
Brauch H.,
Decker J.,
Vocke C.,
Brown J.A.,
Jenkins R.,
Richard S.,
Bergerheim U.,
Gerrard B.,
Dean M.,
Linehan W.M.,
Zbar B.;
"Novel mutations of the MET proto-oncogene in papillary renal carcinomas.";
Oncogene 18:2343-2350(1999).
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[23]
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VARIANT GASTRIC CANCER SER-991, VARIANT ILE-992, CHARACTERIZATION OF VARIANT GASTRIC CANCER SER-991, AND CHARACTERIZATION OF VARIANT ILE-992.
DOI=10.1038/sj.onc.1203874; PubMed=11042681 [NCBI, ExPASy, EBI, Israel, Japan]
Lee J.-H.,
Han S.-U.,
Cho H.,
Jennings B.,
Gerrard B.,
Dean M.,
Schmidt L.,
Zbar B.,
Vande Woude G.F.V.;
"A novel germ line juxtamembrane Met mutation in human gastric cancer.";
Oncogene 19:4947-4953(2000).
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[24]
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VARIANT GASTRIC CANCER LEU-773.
DOI=10.1136/jmg.40.8.e97; PubMed=12920089 [NCBI, ExPASy, EBI, Israel, Japan]
Kim I.-J.,
Park J.-H.,
Kang H.C.,
Shin Y.,
Lim S.-B.,
Ku J.-L.,
Yang H.-K.,
Lee K.U.,
Park J.-G.;
"A novel germline mutation in the MET extracellular domain in a Korean patient with the diffuse type of familial gastric cancer.";
J. Med. Genet. 40:E97-E97(2003).
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[25]
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INTERACTION WITH SPSB1; SPSB2; SPSB3 AND SPSB4.
DOI=10.1074/jbc.M413897200; PubMed=15713673 [NCBI, ExPASy, EBI, Israel, Japan]
Wang D.,
Li Z.,
Messing E.M.,
Wu G.;
"The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway.";
J. Biol. Chem. 280:16393-16401(2005).
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[26]
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INVOLVEMENT IN SUSCEPTIBILITY TO AUTS1B, AND VARIANTS CYS-970 AND ILE-992.
DOI=10.1073/pnas.0605296103; PubMed=17053076 [NCBI, ExPASy, EBI, Israel, Japan]
Campbell D.B.,
Sutcliffe J.S.,
Ebert P.J.,
Militerni R.,
Bravaccio C.,
Trillo S.,
Elia M.,
Schneider C.,
Melmed R.,
Sacco R.,
Persico A.M.,
Levitt P.;
"A genetic variant that disrupts MET transcription is associated with autism.";
Proc. Natl. Acad. Sci. U.S.A. 103:16834-16839(2006).
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[27]
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VARIANTS [LARGE SCALE ANALYSIS] GLN-143; LEU-156; ASP-168; SER-375; CYS-970 AND ILE-992.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
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