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UniProtKB/Swiss-Prot entry P08581


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MET_HUMAN
Primary accession number P08581
Secondary accession numbers O60366 Q12875 Q9UDX7 Q9UPL8
Integrated into Swiss-Prot on August 1, 1988
Sequence was last modified on December 1, 1992 (Sequence version 3)
Annotations were last modified on    November 4, 2008 (Entry version 126)
Name and origin of the protein
Protein name Hepatocyte growth factor receptor [Precursor]
Synonyms HGF receptor
EC 2.7.10.1
Scatter factor receptor
SF receptor
HGF/SF receptor
Met proto-oncogene tyrosine kinase
c-Met
Gene name
Name: MET
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
PubMed=2819873 [NCBI, ExPASy, EBI, Israel, Japan]
Park M., Dean M., Kaul K., Braun M.J., Gonda M.A., Vande Woude G.;
"Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.";
Proc. Natl. Acad. Sci. U.S.A. 84:6379-6383(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Giordano S.;
Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature01782; PubMed=12853948 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 1010-1390.
PubMed=3325883 [NCBI, ExPASy, EBI, Israel, Japan]
Chan A.M.-L., King H.W.S., Tempest P.R., Deakin E.A., Cooper C.S., Brookes P.;
"Primary structure of the met protein tyrosine kinase domain.";
Oncogene 1:229-233(1987).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 1206-1264.
PubMed=8247543 [NCBI, ExPASy, EBI, Israel, Japan]
Lee S.-T., Strunk K.M., Spritz R.A.;
"A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.";
Oncogene 8:3403-3410(1993).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 1267-1390.
DOI=10.1038/318385a0; PubMed=4069211 [NCBI, ExPASy, EBI, Israel, Japan]
Dean M., Park M., le Beau M.M., Robins T.S., Diaz M.O., Rowley J.D., Blair D.G., Vande Woude G.F.;
"The human met oncogene is related to the tyrosine kinase oncogenes.";
Nature 318:385-388(1985).
[7]
FUNCTION.
PubMed=1846706 [NCBI, ExPASy, EBI, Israel, Japan]
Bottaro D.P., Rubin J.S., Faletto D.L., Chan A.M.-L., Kmiecik T.E., Vande Woude G.F., Aaronson S.A.;
"Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.";
Science 251:802-804(1991).
[8]
PHOSPHORYLATION AT TYR-1235, AND ATP-BINDING SITE LYS-1110.
PubMed=1655790 [NCBI, ExPASy, EBI, Israel, Japan]
Ferracini R., Longati P., Naldini L., Vigna E., Comoglio P.M.;
"Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase.";
J. Biol. Chem. 266:19558-19564(1991).
[9]
INTERACTION WITH RANBP9.
DOI=10.1074/jbc.M205111200; PubMed=12147692 [NCBI, ExPASy, EBI, Israel, Japan]
Wang D., Li Z., Messing E.M., Wu G.;
"Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM.";
J. Biol. Chem. 277:36216-36222(2002).
[10]
INTERACTION WITH PLXNB1.
DOI=10.1038/ncb843; PubMed=12198496 [NCBI, ExPASy, EBI, Israel, Japan]
Giordano S., Corso S., Conrotto P., Artigiani S., Gilestro G., Barberis D., Tamagnone L., Comoglio P.M.;
"The semaphorin 4D receptor controls invasive growth by coupling with Met.";
Nat. Cell Biol. 4:720-724(2002).
[11]
INTERACTION WITH RANBP9 AND RANBP10.
DOI=10.1016/j.bbrc.2003.11.124; PubMed=14684163 [NCBI, ExPASy, EBI, Israel, Japan]
Wang D., Li Z., Schoen S.R., Messing E.M., Wu G.;
"A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling.";
Biochem. Biophys. Res. Commun. 313:320-326(2004).
[12]
PHOSPHORYLATION AT TYR-1356, AND INTERACTION WITH INPPL1.
DOI=10.1038/sj.onc.1208558; PubMed=15735664 [NCBI, ExPASy, EBI, Israel, Japan]
Koch A., Mancini A., El Bounkari O., Tamura T.;
"The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading.";
Oncogene 24:3436-3447(2005).
[13]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1003; TYR-1230; TYR-1234 AND TYR-1235, AND MASS SPECTROMETRY.
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
[14]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-977; SER-988; SER-990 AND TYR-1003, AND MASS SPECTROMETRY.
DOI=10.1074/mcp.T600062-MCP200; PubMed=17192257 [NCBI, ExPASy, EBI, Israel, Japan]
Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R., Keri G., Wehland J., Daub H.;
"Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.";
Mol. Cell. Proteomics 6:537-547(2007).
[15]
X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1356-1359 IN COMPLEX WITH GRB2.
DOI=10.1021/bi0012336; PubMed=11063574 [NCBI, ExPASy, EBI, Israel, Japan]
Schiering N., Casale E., Caccia P., Giordano P., Battistini C.;
"Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex.";
Biochemistry 39:13376-13382(2000).
[16]
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1049-1360 IN COMPLEX WITH INHIBITOR.
DOI=10.1073/pnas.1734128100; PubMed=14559966 [NCBI, ExPASy, EBI, Israel, Japan]
Schiering N., Knapp S., Marconi M., Flocco M.M., Cui J., Perego R., Rusconi L., Cristiani C.;
"Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a.";
Proc. Natl. Acad. Sci. U.S.A. 100:12654-12659(2003).
[17]
VARIANTS HPRC THR-1131; LEU-1188; VAL-1195; ILE-1220; HIS-1228; ASN-1228; CYS-1230; HIS-1230 AND THR-1250, AND VARIANT VAL-320.
DOI=10.1038/ng0597-68; PubMed=9140397 [NCBI, ExPASy, EBI, Israel, Japan]
Schmidt L., Duh F.-M., Chen F., Kishida T., Glenn G., Choyke P., Scherer S.W., Zhuang Z., Lubensky I., Dean M., Allikmets R., Chidambaram A., Bergerheim U.R., Feltis J.T., Casadevall C., Zamarron A., Bernues M., Richard S., Lips C.J.M., Walther M.M., Tsui L.-C., Geil L., Orcutt M.L., Stackhouse T., Lipan J., Slife L., Brauch H., Decker J., Niehans G., Hughson M.D., Moch H., Storkel S., Lerman M.I., Linehan W.M., Zbar B.;
"Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas.";
Nat. Genet. 16:68-73(1997).
[18]
VARIANT HPRC ARG-1094, AND CHARACTERIZATION OF VARIANT HPRC ARG-1094.
PubMed=9563489 [NCBI, ExPASy, EBI, Israel, Japan]
Schmidt L., Junker K., Weirich G., Glenn G., Choyke P., Lubensky I., Zhuang Z., Jeffers M., Vande Woude G., Neumann H., Walther M., Linehan W.M., Zbar B.;
"Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene.";
Cancer Res. 58:1719-1722(1998).
[19]
VARIANTS HPRC ILE-1092; ARG-1094; ASP-1106; THR-1131; LEU-1188; ASP-1230; CYS-1230 AND THR-1250.
PubMed=10433944 [NCBI, ExPASy, EBI, Israel, Japan]
Lubensky I.A., Schmidt L., Zhuang Z., Weirich G., Pack S., Zambrano N., Walther M.M., Choyke P., Linehan W.M., Zbar B.;
"Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype.";
Am. J. Pathol. 155:517-526(1999).
[20]
VARIANTS HCC ILE-1173; ARG-1244 AND ILE-1250.
PubMed=9927037 [NCBI, ExPASy, EBI, Israel, Japan]
Park W.S., Dong S.M., Kim S.Y., Na E.Y., Shin M.S., Pi J.H., Kim B.J., Bae J.H., Hong Y.K., Lee K.S., Lee S.H., Yoo N.J., Jang J.J., Pack S., Zhuang Z., Schmidt L., Zbar B., Lee J.Y.;
"Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas.";
Cancer Res. 59:307-310(1999).
[21]
VARIANT HPRC ILE-1092, AND CHARACTERIZATION OF VARIANT HPRC ILE-1092.
DOI=10.1002/(SICI)1097-0215(19990827)82:5<640::AID-IJC4>3.0.CO;2-6; PubMed=10417759 [NCBI, ExPASy, EBI, Israel, Japan]
Olivero M., Valente G., Bardelli A., Longati P., Ferrero N., Cracco C., Terrone C., Rocca-Rossetti S., Comoglio P.M., Di Renzo M.F.;
"Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinase in a HPRCC family.";
Int. J. Cancer 82:640-643(1999).
[22]
VARIANTS HPRC ILE-1092; LEU-1094; TYR-1094; ASP-1106 AND ASP-1230, AND CHARACTERIZATION OF VARIANTS HPRC ILE-1092; LEU-1094; TYR-1094; ASP-1106 AND ASP-1230.
DOI=10.1038/sj.onc.1202547; PubMed=10327054 [NCBI, ExPASy, EBI, Israel, Japan]
Schmidt L., Junker K., Nakaigawa N., Kinjerski T., Weirich G., Miller M., Lubensky I., Neumann H.P.H., Brauch H., Decker J., Vocke C., Brown J.A., Jenkins R., Richard S., Bergerheim U., Gerrard B., Dean M., Linehan W.M., Zbar B.;
"Novel mutations of the MET proto-oncogene in papillary renal carcinomas.";
Oncogene 18:2343-2350(1999).
[23]
VARIANT GASTRIC CANCER SER-991, VARIANT ILE-992, CHARACTERIZATION OF VARIANT GASTRIC CANCER SER-991, AND CHARACTERIZATION OF VARIANT ILE-992.
DOI=10.1038/sj.onc.1203874; PubMed=11042681 [NCBI, ExPASy, EBI, Israel, Japan]
Lee J.-H., Han S.-U., Cho H., Jennings B., Gerrard B., Dean M., Schmidt L., Zbar B., Vande Woude G.F.V.;
"A novel germ line juxtamembrane Met mutation in human gastric cancer.";
Oncogene 19:4947-4953(2000).
[24]
VARIANT GASTRIC CANCER LEU-773.
DOI=10.1136/jmg.40.8.e97; PubMed=12920089 [NCBI, ExPASy, EBI, Israel, Japan]
Kim I.-J., Park J.-H., Kang H.C., Shin Y., Lim S.-B., Ku J.-L., Yang H.-K., Lee K.U., Park J.-G.;
"A novel germline mutation in the MET extracellular domain in a Korean patient with the diffuse type of familial gastric cancer.";
J. Med. Genet. 40:E97-E97(2003).
[25]
INTERACTION WITH SPSB1; SPSB2; SPSB3 AND SPSB4.
DOI=10.1074/jbc.M413897200; PubMed=15713673 [NCBI, ExPASy, EBI, Israel, Japan]
Wang D., Li Z., Messing E.M., Wu G.;
"The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway.";
J. Biol. Chem. 280:16393-16401(2005).
[26]
INVOLVEMENT IN SUSCEPTIBILITY TO AUTS1B, AND VARIANTS CYS-970 AND ILE-992.
DOI=10.1073/pnas.0605296103; PubMed=17053076 [NCBI, ExPASy, EBI, Israel, Japan]
Campbell D.B., Sutcliffe J.S., Ebert P.J., Militerni R., Bravaccio C., Trillo S., Elia M., Schneider C., Melmed R., Sacco R., Persico A.M., Levitt P.;
"A genetic variant that disrupts MET transcription is associated with autism.";
Proc. Natl. Acad. Sci. U.S.A. 103:16834-16839(2006).
[27]
VARIANTS [LARGE SCALE ANALYSIS] GLN-143; LEU-156; ASP-168; SER-375; CYS-970 AND ILE-992.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
J02958; AAA59591.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X54559; CAB56793.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC002080; AAB54047.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC002543; AAC60383.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC004416; AAF66137.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U08818; AAB60323.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M35074; AAA59590.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A40175; TVHUME.
RefSeq NP_000236.2; -.
NP_001120972.1; -.
UniGene Hs.132966
3D structure databases
PDB
1FYR; X-ray; 2.40 A; I/J/K/L=1356-1359.[ExPASy / RCSB / EBI]
1R0P; X-ray; 1.80 A; A=1049-1360.[ExPASy / RCSB / EBI]
1R1W; X-ray; 1.80 A; A=1049-1360.[ExPASy / RCSB / EBI]
1SHY; X-ray; 3.22 A; B=25-567.[ExPASy / RCSB / EBI]
1SSL; NMR; -; A=519-562.[ExPASy / RCSB / EBI]
1UX3; Model; -; A=25-656.[ExPASy / RCSB / EBI]
2G15; X-ray; 2.15 A; A=1038-1346.[ExPASy / RCSB / EBI]
2UZX; X-ray; 2.80 A; B/D=25-741.[ExPASy / RCSB / EBI]
2UZY; X-ray; 4.00 A; B/D=25-741.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1FYR; -.
1R0P; -.
1R1W; -.
1SHY; -.
1SSL; -.
1UX3; -.
2G15; -.
2UZX; -.
2UZY; -.
DisProt DP00317; -.
ModBase P08581.
Protein-protein interaction databases
DIP DIP:6023N; -.
IntAct P08581; -.
PTM databases
PhosphoSite P08581; -.
2D gel databases
OGP P08581; -.
Organism-specific databases
H-InvDB HIX0007019; -.
HGNC HGNC:7029; MET.
GenAtlas MET.
HPA CAB005282; -.
MIM 114550; phenotype. [NCBI / EBI]
164860; gene. [NCBI / EBI]
605074; phenotype. [NCBI / EBI]
608636; phenotype. [NCBI / EBI]
Orphanet 106; Autism.
88673; Hepatocellular carcinoma.
33402; Hepatocellular carcinoma of childhood.
47044; Renal cell carcinoma, papillary, familial.
PharmGKB PA24993; -.
GeneCards P08581.
Gene expression databases
ArrayExpress P08581; -.
CleanEx HS_MET; -.
GermOnline ENSG00000105976; Homo sapiens.
Ontologies
GO
GO:0009925; Cellular component: basal plasma membrane (inferred from direct assay from MGI).
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0005008; Molecular function: hepatocyte growth factor receptor activity (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from UniProtKB).
GO:0008283; Biological process: cell proliferation (traceable author statement from ProtInc).
GO:0007166; Biological process: cell surface receptor linked signal transduction (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR002909; IPT_TIG_rcpt.
IPR003659; Plexin-like.
IPR002165; Plexin_repeat.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR001627; Sema.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
IPR016244; TyrPK_HGF-R.
IPR015943; WD40/YVTN_repeat-like.
Graphical view of domain structure.
Gene3D G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1.
Pfam PF07714; Pkinase_Tyr; 1.
PF01437; PSI; 1.
PF01403; Sema; 1.
PF01833; TIG; 3.
Pfam graphical view of domain structure.
PIRSF PIRSF000617; TyrPK_HGF-R; 1.
PRINTS PR00109; TYRKINASE.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00429; IPT; 4.
SM00423; PSI; 1.
SM00630; Sema; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.
PROSITE PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS51004; SEMA; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P08581.
ProtoNet P08581.
Genome annotation databases
Ensembl ENSG00000105976; Homo sapiens. [Contig view]
GeneID 4233; -.
KEGG hsa:4233; -.
Phylogenomic databases
HOGENOM P08581; -.
HOVERGEN P08581; -.
Other
BindingDB P08581; -.
LinkHub P08581; -.
NextBio 16689; -.
SOURCE MET; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; ATP-binding; Chromosomal rearrangement; Disease mutation; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Proto-oncogene; Receptor; Repeat; Signal; Transferase; Transmembrane; Tyrosine-protein kinase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     24  24     Potential. 
CHAIN   25   1390  1366     Hepatocyte growth factor receptor. PRO_0000024440
TOPO_DOM   25    932  908     Extracellular (Potential). 
TRANSMEM   933    955  23     Potential. 
TOPO_DOM   956   1390  435     Cytoplasmic (Potential). 
DOMAIN   27    515  489     Sema. 
DOMAIN   563    655  93     IPT/TIG 1. 
DOMAIN   657    739  83     IPT/TIG 2. 
DOMAIN   742    836  95     IPT/TIG 3. 
DOMAIN   1078   1345  268     Protein kinase. 
NP_BIND   1084   1092  9     ATP (By similarity). 
REGION   1212   1390  179     Interaction with RANBP9. 
ACT_SITE   1204   1204        Proton acceptor (By similarity). 
BINDING   1110   1110        ATP. 
SITE   307    308  2     Cleavage (Potential). 
SITE   1009   1010  2     Breakpoint for translocation to form TPR-MET oncogene. 
MOD_RES   977    977        Phosphothreonine. 
MOD_RES   988    988        Phosphoserine. 
MOD_RES   990    990        Phosphoserine. 
MOD_RES   1003   1003        Phosphotyrosine. 
MOD_RES   1230   1230        Phosphotyrosine. 
MOD_RES   1234   1234        Phosphotyrosine. 
MOD_RES   1235   1235        Phosphotyrosine; by autocatalysis. 
MOD_RES   1356   1356        Phosphotyrosine. 
CARBOHYD   45     45        N-linked (GlcNAc...) (Potential). 
CARBOHYD   106    106        N-linked (GlcNAc...) (Potential). 
CARBOHYD   149    149