ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P08495


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name AK2_BACSU
Primary accession number P08495
Secondary accession numbers P08496 P94554 P97183
Integrated into Swiss-Prot on August 1, 1988
Sequence was last modified on August 4, 2003 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 85)
Name and origin of the protein
Protein name Aspartokinase 2
Synonyms EC 2.7.2.4
Aspartokinase II
Aspartate kinase 2
Gene name
Name: lysC
OrderedLocusNames: BSU28470
From
Bacillus subtilis [TaxID: 1423] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3036830 [NCBI, ExPASy, EBI, Israel, Japan]
Chen N.-Y., Hu F.M., Paulus H.;
"Nucleotide sequence of the overlapping genes for the subunits of Bacillus subtilis aspartokinase II and their control regions.";
J. Biol. Chem. 262:8787-8798(1987).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=168;
PubMed=8969504 [NCBI, ExPASy, EBI, Israel, Japan]
Wipat A., Carter N., Brignell C.S., Guy J.B., Piper K., Sanders J., Emmerson P.T., Harwood C.R.;
"The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis chromosome containing genes responsible for stress responses, the utilization of plant cell walls and primary metabolism.";
Microbiology 142:3067-3078(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=168;
DOI=10.1038/36786; PubMed=9384377 [NCBI, ExPASy, EBI, Israel, Japan]
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.;
"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.";
Nature 390:249-256(1997).
[4]
ALTERNATIVE INITIATION.
PubMed=2837491 [NCBI, ExPASy, EBI, Israel, Japan]
Chen N.-Y., Paulus H.;
"Mechanism of expression of the overlapping genes of Bacillus subtilis aspartokinase II.";
J. Biol. Chem. 263:9526-9532(1988).
[5]
REGULATION BY DEGRADATION.
PubMed=2168395 [NCBI, ExPASy, EBI, Israel, Japan]
Graves L.M., Switzer R.L.;
"Aspartokinase II from Bacillus subtilis is degraded in response to nutrient limitation.";
J. Biol. Chem. 265:14947-14955(1990).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
J03294; AAA87318.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
J03294; AAA87319.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z75208; CAA99580.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z75208; CAA99581.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z99118; CAB14807.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A29314; A29314.
RefSeq NP_390725.1; -.
3D structure databases
ModBase P08495.
Enzyme and pathway databases
BioCyc BSUB224308:BSU2843-MON; -.
MetaCyc:MON-6561; -.
MetaCyc:MON-6562; -.
Organism-specific databases
SubtiList BG10350; lysC. [Micado]
Ontologies
GO
GO:0019877; Biological process: diaminopimelate biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002912; ACT_bd.
IPR001048; Asp/Glu/Uridylate_kinase.
IPR005260; Asp_kin_monofn.
IPR001341; Asp_kin_reg.
Graphical view of domain structure.
Gene3D G3DSA:3.40.1160.10; Aa_kinase; 1.
Pfam PF00696; AA_kinase; 1.
PF01842; ACT; 2.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00656; asp_kin_monofn; 1.
TIGR00657; asp_kinases; 1.
PROSITE PS00324; ASPARTOKINASE; 1.
BLOCKS P08495.
ProtoNet P08495.
Genome annotation databases
GeneID 937451; -.
GenomeReviews AL009126_GR; BSU28470.
KEGG bsu:BSU28470; -.
NMPDR fig|224308.1.peg.2850; -.
Phylogenomic databases
HOGENOM P08495; -.
Genome annotation databases
CMR P08495; BSU28470.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative initiation; Amino-acid biosynthesis; Complete proteome; Diaminopimelate biosynthesis; Kinase; Lysine biosynthesis; Repeat; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   408  408     Aspartokinase 2. PRO_0000002373
DOMAIN   276   335  60     ACT 1. 
DOMAIN   342   407  66     ACT 2. 
VAR_SEQ   1   245        Missing (in isoform Beta). VSP_018655
CONFLICT   166   166        A -> V (in Ref. 1; AAA87318). 
Sequence information
Length: 408 AA [This is the length of the unprocessed precursor] Molecular weight: 43808 Da [This is the MW of the unprocessed precursor] CRC64: 2E7189F938F97120 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGLIVQKFGG TSVGSVEKIQ NAANRAIAEK QKGHQVVVVV SAMGKSTDEL VSLAKAISDQ 

        70         80         90        100        110        120 
PSKREMDMLL ATGEQVTISL LSMALQEKGY DAVSYTGWQA GIRTEAIHGN ARITDIDTSV 

       130        140        150        160        170        180 
LADQLEKGKI VIVAGFQGMT EDCEITTLGR GGSDTTAVAL AAALKADKCD IYTDVPGVFT 

       190        200        210        220        230        240 
TDPRYVKSAR KLEGISYDEM LELANLGAGV LHPRAVEFAK NYQVPLEVRS STETEAGTLI 

       250        260        270        280        290        300 
EEESSMEQNL IVRGIAFEDQ ITRVTIYGLT SGLTTLSTIF TTLAKRNINV DIIIQTQAED 

       310        320        330        340        350        360 
KTGISFSVKT EDADQTVAVL EEYKDALEFE KIETESKLAK VSIVGSGMVS NPGVAAEMFA 

       370        380        390        400 
VLAQKNILIK MVSTSEIKVS TVVSENDMVK AVESLHDAFE LSKHPSAV 

P08495 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!