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UniProtKB/Swiss-Prot entry P08247


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SYPH_HUMAN
Primary accession number P08247
Secondary accession number Q6P2F7
Integrated into Swiss-Prot on August 1, 1988
Sequence was last modified on August 1, 1991 (Sequence version 3)
Annotations were last modified on    June 16, 2009 (Entry version 82)
Name and origin of the protein
Protein name Synaptophysin
Synonym Major synaptic vesicle protein p38
Gene name
Name: SYP
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1093/nar/15.22.9607; PubMed=3120152 [NCBI, ExPASy, EBI, Israel, Japan]
Suedhof T.C., Lottspeich F., Greengard P., Mehl E., Jahn R.;
"The cDNA and derived amino acid sequences for rat and human synaptophysin.";
Nucleic Acids Res. 15:9607-9607(1987).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1975480 [NCBI, ExPASy, EBI, Israel, Japan]
Oezcelik T., Lafreniere R.G., Archer B.T. III, Johnston P.A., Willard H.F., Francke U., Suedhof T.C.;
"Synaptophysin: structure of the human gene and assignment to the X chromosome in man and mouse.";
Am. J. Hum. Genet. 47:551-561(1990).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.1997.4941; PubMed=9344658 [NCBI, ExPASy, EBI, Israel, Japan]
Fisher S.E., Ciccodicola A., Tanaka K., Curci A., Desicato S., D'Urso M., Craig I.W.;
"Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp.";
Genomics 45:340-347(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X06389; CAA29686.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U93305; AAB92358.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC064550; AAH64550.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00027770; -.
PIR A35699; A35699.
RefSeq NP_003170.1; -.
UniGene Hs.632804
3D structure databases
ModBase P08247.
PTM databases
PhosphoSite P08247; -.
Organism-specific databases
GeneCards GC0XM048931; -.
H-InvDB HIX0016771; -.
HGNC HGNC:11506; SYP.
GenAtlas SYP.
HPA CAB000076; -.
HPA002858; -.
MIM 313475; gene. [NCBI / EBI]
PharmGKB PA36288; -.
Gene expression databases
ArrayExpress P08247; -.
Bgee P08247; -.
CleanEx HS_SYP; -.
GermOnline ENSG00000102003; Homo sapiens.
Ontologies
GO
GO:0030054; Cellular component: cell junction (inferred from electronic annotation from UniProtKB-SubCell).
GO:0030285; Cellular component: integral to synaptic vesicle membrane (non-traceable author statement from UniProtKB).
GO:0030141; Cellular component: secretory granule (inferred from electronic annotation from UniProtKB-SubCell).
GO:0019717; Cellular component: synaptosome (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005509; Molecular function: calcium ion binding (non-traceable author statement from UniProtKB).
GO:0015485; Molecular function: cholesterol binding (inferred from direct assay from UniProtKB).
GO:0005515; Molecular function: protein binding (non-traceable author statement from UniProtKB).
GO:0005215; Molecular function: transporter activity (inferred from electronic annotation from InterPro).
GO:0016188; Biological process: synaptic vesicle maturation (non-traceable author statement from UniProtKB).
GO:0048499; Biological process: synaptic vesicle membrane organization (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR008253; Marvel.
IPR001285; Synaptophysin/porin.
IPR015457; Synaptophysin_.
Graphical view of domain structure.
PANTHER PTHR10306; Synaptophysin; 1.
PTHR10306:SF2; Synaptophysin_; 1.
Pfam PF01284; MARVEL; 1.
Pfam graphical view of domain structure.
PRINTS PR00220; SYNAPTOPHYSN.
PROSITE PS51225; MARVEL; 1.
PS00604; SYNAPTOP; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE P08247; -.
Genome annotation databases
Ensembl ENSG00000102003; Homo sapiens. [Contig view]
GeneID 6855; -.
KEGG hsa:6855; -.
Phylogenomic databases
HOGENOM P08247; -.
HOVERGEN P08247; -.
OMA P08247; TGNTCKE.
Other
NextBio 26757; -.
SOURCE SYP; Homo sapiens.
ProtoNet P08247.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Cell junction; Cytoplasmic vesicle; Glycoprotein; Membrane; Phosphoprotein; Repeat; Synapse; Synaptosome; Transmembrane; Ubl conjugation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   313  313     Synaptophysin. PRO_0000179161
TOPO_DOM   1    25  25     Cytoplasmic (Potential). 
TRANSMEM   26    49  24     Potential. 
TOPO_DOM   50   106  57     Vesicular (Potential). 
TRANSMEM   107   130  24     Potential. 
TOPO_DOM   131   137  7     Cytoplasmic (Potential). 
TRANSMEM   138   161  24     Potential. 
TOPO_DOM   162   199  38     Vesicular (Potential). 
TRANSMEM   200   223  24     Potential. 
TOPO_DOM   224   313  90     Cytoplasmic (Potential). 
DOMAIN   21   227  207     MARVEL. 
REGION   254   305  52     Repeats, Gly-rich. 
MOD_RES   81    81        Phosphotyrosine (By similarity). 
CARBOHYD   59    59        N-linked (GlcNAc...) (Potential). 
CONFLICT   196   196        P -> L (in Ref. 4; AAH64550). 
Sequence information
Length: 313 AA [This is the length of the unprocessed precursor] Molecular weight: 33845 Da [This is the MW of the unprocessed precursor] CRC64: 592289C43B12EFA7 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLLLADMDVV NQLVAGGQFR VVKEPLGFVK VLQWVFAIFA FATCGSYSGE LQLSVDCANK 

        70         80         90        100        110        120 
TESDLSIEVE FEYPFRLHQV YFDAPTCRGG TTKVFLVGDY SSSAEFFVTV AVFAFLYSMG 

       130        140        150        160        170        180 
ALATYIFLQN KYRENNKGPM LDFLATAVFA FMWLVSSSAW AKGLSDVKMA TDPENIIKEM 

       190        200        210        220        230        240 
PVCRQTGNTC KELRDPVTSG LNTSVVFGFL NLVLWVGNLW FVFKETGWAA PFLRAPPGAP 

       250        260        270        280        290        300 
EKQPAPGDAY GDAGYGQGPG GYGPQDSYGP QGGYQPDYGQ PAGSGGSGYG PQGDYGQQGY 

       310 
GPQGAPTSFS NQM 

P08247 in FASTA format

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