ID   ARAB_ECOLI              Reviewed;         566 AA.
AC   P08204; P78041;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 4.
DT   22-JUL-2008, entry version 74.
DE   RecName: Full=Ribulokinase;
DE            EC=2.7.1.16;
GN   Name=araB; OrderedLocusNames=b0063, JW0062;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=87163495; PubMed=3549454; DOI=10.1016/0378-1119(86)90067-3;
RA   Lee N., Gielow W., Martin R., Hamilton E., Fowler A.;
RT   "The organization of the araBAD operon of Escherichia coli.";
RL   Gene 47:231-244(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12;
RX   MEDLINE=92334977; PubMed=1630901; DOI=10.1093/nar/20.13.3305;
RA   Yura T., Mori H., Nagai H., Nagata T., Ishihama A., Fujita N.,
RA   Isono K., Mizobuchi K., Nakata A.;
RT   "Systematic sequencing of the Escherichia coli genome: analysis of the
RT   0-2.4 min region.";
RL   Nucleic Acids Res. 20:3305-3308(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA   Mau B., Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1474(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND SEQUENCE REVISION.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains
RT   MG1655 and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-14, AND PROTEIN SEQUENCE OF 2-14.
RX   MEDLINE=77102763; PubMed=189315;
RA   Lee N., Carbon J.;
RT   "Nucleotide sequence of the 5' end of araBAD operon messenger RNA in
RT   Escherichia coli B/r.";
RL   Proc. Natl. Acad. Sci. U.S.A. 74:49-53(1977).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-6.
RC   STRAIN=K12;
RX   MEDLINE=79005683; PubMed=357433;
RA   Smith B.R., Schleif R.;
RT   "Nucleotide sequence of the L-arabinose regulatory region of
RT   Escherichia coli K12.";
RL   J. Biol. Chem. 253:6931-6933(1978).
CC   -!- CATALYTIC ACTIVITY: ATP + L(or D)-ribulose = ADP + L(or D)-
CC       ribulose 5-phosphate.
CC   -!- PATHWAY: Carbohydrate degradation; L-arabinose degradation via L-
CC       ribulose; D-xylulose 5-phosphate from L-arabinose (bacteria
CC       route): step 2/3.
CC   -!- INTERACTION:
CC       P18843:nadE; NbExp=1; IntAct=EBI-1113458, EBI-548960;
CC   -!- SIMILARITY: Belongs to the ribulokinase family.
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DR   EMBL; M15263; AAA23462.1; -; Genomic_DNA.
DR   EMBL; J01641; AAA23467.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC73174.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAB96632.2; -; Genomic_DNA.
DR   EMBL; K01304; AAA23465.1; -; mRNA.
DR   PIR; G64727; KIECRU.
DR   RefSeq; AP_000727.1; -.
DR   RefSeq; NP_414605.1; -.
DR   IntAct; P08204; -.
DR   ECO2DBASE; D055.0; 6TH EDITION.
DR   GeneID; 946017; -.
DR   GenomeReviews; U00096_GR; b0063.
DR   GenomeReviews; AP009048_GR; JW0062.
DR   KEGG; ecj:JW0062; -.
DR   KEGG; eco:b0063; -.
DR   EchoBASE; EB0051; -.
DR   EcoGene; EG10053; araB.
DR   HOGENOM; P08204; -.
DR   BioCyc; EcoCyc:RIBULOKIN-MON; -.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   HAMAP; MF_00520; -; 1.
DR   InterPro; IPR000577; FGGY_kin.
DR   InterPro; IPR005929; L_ribulokin.
DR   PANTHER; PTHR10196; FGGY_kin; 1.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   TIGRFAMs; TIGR01234; L-ribulokinase; 1.
PE   1: Evidence at protein level;
KW   Arabinose catabolism; Carbohydrate metabolism; Complete proteome;
KW   Direct protein sequencing; Kinase; Transferase.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    566       Ribulokinase.
FT                                /FTId=PRO_0000198358.
FT   CONFLICT     23     23       T -> S (in Ref. 1 and 2).
FT   CONFLICT    127    128       EA -> RS (in Ref. 1 and 2).
FT   CONFLICT    350    350       G -> S (in Ref. 1 and 2).
FT   CONFLICT    365    365       T -> A (in Ref. 1 and 2).
FT   CONFLICT    403    403       T -> S (in Ref. 1 and 2).
FT   CONFLICT    525    525       C -> R (in Ref. 1 and 2).
SQ   SEQUENCE   566 AA;  61089 MW;  4A12010092139D8A CRC64;
     MAIAIGLDFG SDSVRALAVD CATGEEIATS VEWYPRWQKG QFCDAPNNQF RHHPRDYIES
     MEAALKTVLA ELSVEQRAAV VGIGVDSTGS TPAPIDADGN VLALRPEFAE NPNAMFVLWK
     DHTAVEEAEE ITRLCHAPGN VDYSRYIGGI YSSEWFWAKI LHVTRQDSAV AQSAASWIEL
     CDWVPALLSG TTRPQDIRRG RCSAGHKSLW HESWGGLPPA SFFDELDPIL NRHLPSPLFT
     DTWTADIPVG TLCPEWAQRL GLPESVVISG GAFDCHMGAV GAGAQPNALV KVIGTSTCDI
     LIADKQSVGE RAVKGICGQV DGSVVPGFIG LEAGQSAFGD IYAWFGRVLG WPLEQLAAQH
     PELKTQINAS QKQLLPALTE AWAKNPSLDH LPVVLDWFNG RRTPNANQRL KGVITDLNLA
     TDAPLLFGGL IAATAFGARA IMECFTDQGI AVNNVMALGG IARKNQVIMQ ACCDVLNRPL
     QIVASDQCCA LGAAIFAAVA AKVHADIPSA QQKMASAVEK TLQPCSEQAQ RFEQLYRRYQ
     QWAMSAEQHY LPTSAPAQAA QAVATL
//