ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P08151


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name GLI1_HUMAN
Primary accession number P08151
Secondary accession number Q8TDN9
Integrated into Swiss-Prot on August 1, 1988
Sequence was last modified on August 1, 1988 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 103)
Name and origin of the protein
Protein name Zinc finger protein GLI1
Synonyms Glioma-associated oncogene
Oncogene GLI
Gene name
Name: GLI1
Synonyms: GLI
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1038/332371a0; PubMed=2832761 [NCBI, ExPASy, EBI, Israel, Japan]
Kinzler K.W., Ruppert J.M., Bigner S.H., Vogelstein B.;
"The GLI gene is a member of the Kruppel family of zinc finger proteins.";
Nature 332:371-374(1988).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ASP-933 AND GLN-1100.
Yoon J.W., Kent P., Clark A., Patterson J., Villavicencio E., Iannaccone P., Walterhouse D.;
"Polymorphic variants of the human oncogene GLI1 function similarly.";
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Muscle;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH STK36 AND SUFU.
DOI=10.1038/35010610; PubMed=10806483 [NCBI, ExPASy, EBI, Israel, Japan]
Murone M., Luoh S.-L., Stone D., Li W., Gurney A., Armanini M., Grey C., Rosenthal A., de Sauvage F.J.;
"Gli regulation by the opposing activities of fused and suppressor of fused.";
Nat. Cell Biol. 2:310-312(2000).
[5]
VARIANTS ALA-884; ASP-933 AND GLN-1100.
DOI=10.1046/j.1523-1747.2000.00065.x; PubMed=10951255 [NCBI, ExPASy, EBI, Israel, Japan]
Wang X.Q., Chan N., Rothnagel J.A.;
"Identification of polymorphic variants of the GLI1 oncogene.";
J. Invest. Dermatol. 115:328-329(2000).
[6]
X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 234-388.
PubMed=8378770 [NCBI, ExPASy, EBI, Israel, Japan]
Pavletich N.P., Pabo C.O.;
"Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.";
Science 261:1701-1707(1993).
[7]
VARIANTS [LARGE SCALE ANALYSIS] ALA-210; ILE-514 AND GLN-817.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X07384; CAA30297.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF316573; AAM13391.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC013000; AAH13000.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S00672; TVHUGL.
RefSeq NP_005260.1; -.
UniGene Hs.632702
3D structure databases
PDB
2GLI; X-ray; 2.60 A; A=232-391.[ExPASy / RCSB / EBI]
PDBsum 2GLI; -.
ModBase P08151.
Protein-protein interaction databases
IntAct P08151; -.
PTM databases
PhosphoSite P08151; -.
Organism-specific databases
HGNC HGNC:4317; GLI1.
GenAtlas GLI1.
HPA CAB009460; -.
MIM 165220; gene. [NCBI / EBI]
Orphanet 360; Glioblastoma.
PharmGKB PA28720; -.
GeneCards P08151.
Gene expression databases
CleanEx HS_GLI1; -.
GermOnline ENSG00000111087; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from UniProtKB).
GO:0003677; Molecular function: DNA binding (inferred from direct assay from MGI).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0016563; Molecular function: transcription activator activity (inferred from direct assay from UniProtKB).
GO:0009913; Biological process: epidermal cell differentiation (inferred from direct assay from UniProtKB).
GO:0001649; Biological process: osteoblast differentiation (inferred from direct assay from UniProtKB).
GO:0008284; Biological process: positive regulation of cell proliferation (inferred from mutant phenotype from UniProtKB).
GO:0045740; Biological process: positive regulation of DNA replication (inferred from direct assay from UniProtKB).
GO:0045944; Biological process: positive regulation of transcription from RNA polymerase II promoter (inferred from direct assay from UniProtKB).
GO:0008589; Biological process: regulation of smoothened signaling pathway (traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR007087; Znf_C2H2.
IPR015880; Znf_C2H2-like.
IPR013087; Znf_C2H2/integrase_DNA-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 4.
Pfam PF00096; zf-C2H2; 5.
Pfam graphical view of domain structure.
ProDom PD000003; Znf_C2H2; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00355; ZnF_C2H2; 5.
SMART graphical view of domain structure.
PROSITE PS00028; ZINC_FINGER_C2H2_1; 4.
PS50157; ZINC_FINGER_C2H2_2; 5.
PROSITE graphical view of domain structure (profiles).
BLOCKS P08151.
ProtoNet P08151.
Genome annotation databases
Ensembl ENSG00000111087; Homo sapiens. [Contig view]
GeneID 2735; -.
KEGG hsa:2735; -.
Phylogenomic databases
HOGENOM P08151; -.
HOVERGEN P08151; -.
Other
LinkHub P08151; -.
NextBio 10780; -.
SOURCE GLI1; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cytoplasm; Developmental protein; Differentiation; DNA-binding; Metal-binding; Nucleus; Polymorphism; Proto-oncogene; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1106  1106     Zinc finger protein GLI1. PRO_0000047197
ZN_FING   235    260  26     C2H2-type 1. 
ZN_FING   268    295  28     C2H2-type 2. 
ZN_FING   301    325  25     C2H2-type 3. 
ZN_FING   331    356  26     C2H2-type 4. 
ZN_FING   362    387  26     C2H2-type 5. 
COMPBIAS   1038   1055  18     Asp/Glu-rich (acidic). 
VARIANT   210    210  1     P -> A (in a breast cancer sample; somatic mutation). VAR_035557 
VARIANT   514    514  1     T -> I (in a breast cancer sample; somatic mutation). VAR_035558 
VARIANT   817    817  1     E -> Q (in a breast cancer sample; somatic mutation). VAR_035559 
VARIANT   884    884  1     D -> A. VAR_015114 
VARIANT   933    933  1     G -> D (in dbSNP:rs2228224 [NCBI]). VAR_015115 
VARIANT   1100   1100  1     E -> Q (in dbSNP:rs2228226 [NCBI]). VAR_015116 
HELIX   249    259  11      
STRAND   261    263  3      
TURN   276    279  4      
HELIX   285    291  7      
HELIX   293    296  4      
HELIX   315    324  10      
STRAND   341    346  6      
HELIX   349    354  6      
TURN   367    369  3      
STRAND   372    375  4      
HELIX   376    381  6      
TURN   382    384  3      
Sequence information
Length: 1106 AA [This is the length of the unprocessed precursor] Molecular weight: 117904 Da [This is the MW of the unprocessed precursor] CRC64: E29B11D1A6CD3D91 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MFNSMTPPPI SSYGEPCCLR PLPSQGAPSV GTEGLSGPPF CHQANLMSGP HSYGPARETN 

        70         80         90        100        110        120 
SCTEGPLFSS PRSAVKLTKK RALSISPLSD ASLDLQTVIR TSPSSLVAFI NSRCTSPGGS 

       130        140        150        160        170        180 
YGHLSIGTMS PSLGFPAQMN HQKGPSPSFG VQPCGPHDSA RGGMIPHPQS RGPFPTCQLK 

       190        200        210        220        230        240 
SELDMLVGKC REEPLEGDMS SPNSTGIQDP LLGMLDGRED LEREEKREPE SVYETDCRWD 

       250        260        270        280        290        300 
GCSQEFDSQE QLVHHINSEH IHGERKEFVC HWGGCSRELR PFKAQYMLVV HMRRHTGEKP 

       310        320        330        340        350        360 
HKCTFEGCRK SYSRLENLKT HLRSHTGEKP YMCEHEGCSK AFSNASDRAK HQNRTHSNEK 

       370        380        390        400        410        420 
PYVCKLPGCT KRYTDPSSLR KHVKTVHGPD AHVTKRHRGD GPLPRAPSIS TVEPKREREG 

       430        440        450        460        470        480 
GPIREESRLT VPEGAMKPQP SPGAQSSCSS DHSPAGSAAN TDSGVEMTGN AGGSTEDLSS 

       490        500        510        520        530        540 
LDEGPCIAGT GLSTLRRLEN LRLDQLHQLR PIGTRGLKLP SLSHTGTTVS RRVGPPVSLE 

       550        560        570        580        590        600 
RRSSSSSSIS SAYTVSRRSS LASPFPPGSP PENGASSLPG LMPAQHYLLR ARYASARGGG 

       610        620        630        640        650        660 
TSPTAASSLD RIGGLPMPPW RSRAEYPGYN PNAGVTRRAS DPAQAADRPA PARVQRFKSL 

       670        680        690        700        710        720 
GCVHTPPTVA GGGQNFDPYL PTSVYSPQPP SITENAAMDA RGLQEEPEVG TSMVGSGLNP 

       730        740        750        760        770        780 
YMDFPPTDTL GYGGPEGAAA EPYGARGPGS LPLGPGPPTN YGPNPCPQQA SYPDPTQETW 

       790        800        810        820        830        840 
GEFPSHSGLY PGPKALGGTY SQCPRLEHYG QVQVKPEQGC PVGSDSTGLA PCLNAHPSEG 

       850        860        870        880        890        900 
PPHPQPLFSH YPQPSPPQYL QSGPYTQPPP DYLPSEPRPC LDFDSPTHST GQLKAQLVCN 

       910        920        930        940        950        960 
YVQSQQELLW EGGGREDAPA QEPSYQSPKF LGGSQVSPSR AKAPVNTYGP GFGPNLPNHK 

       970        980        990       1000       1010       1020 
SGSYPTPSPC HENFVVGANR ASHRAAAPPR LLPPLPTCYG PLKVGGTNPS CGHPEVGRLG 

      1030       1040       1050       1060       1070       1080 
GGPALYPPPE GQVCNPLDSL DLDNTQLDFV AILDEPQGLS PPPSHDQRGS SGHTPPPSGP 

      1090       1100 
PNMAVGNMSV LLRSLPGETE FLNSSA 

P08151 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!