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UniProtKB/Swiss-Prot entry P08080


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HEM1_RHIME
Primary accession number P08080
Secondary accession numbers None
Integrated into Swiss-Prot on August 1, 1988
Sequence was last modified on October 18, 2001 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 73)
Name and origin of the protein
Protein name 5-aminolevulinate synthase
Synonyms EC 2.3.1.37
5-aminolevulinic acid synthase
Delta-aminolevulinate synthase
Delta-ALA synthetase
Gene name
Name: hemA
OrderedLocusNames: R02989
ORFNames: SMc03104
From
Rhizobium meliloti (Sinorhizobium meliloti) [TaxID: 382] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=1021;
DOI=10.1073/pnas.161294398; PubMed=11481430 [NCBI, ExPASy, EBI, Israel, Japan]
Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J., Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S., Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.;
"Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021.";
Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-74.
DOI=10.1093/nar/13.16.5965; PubMed=2994020 [NCBI, ExPASy, EBI, Israel, Japan]
Leong S.A., Williams P.H., Ditta G.S.;
"Analysis of the 5' regulatory region of the gene for delta-aminolevulinic acid synthetase of Rhizobium meliloti.";
Nucleic Acids Res. 13:5965-5976(1985).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL591688; CAC47568.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X02853; CAA26610.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A24077; A24077.
RefSeq NP_387095.1; -.
3D structure databases
HSSP P07912; 1FC4. [HSSP ENTRY / PDB]
ModBase P08080.
Enzyme and pathway databases
BioCyc SMEL266834:SMC03104-MON; -.
Ontologies
GO
GO:0006783; Biological process: heme biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR010961; 4pyrrol_synth_NH2levulA_synth.
IPR004839; Aminotrans_I/II.
IPR001917; Aminotrans_II_pyridoxalP_BS.
IPR015421; PyrdxlP-dep_Trfase_major_sub1.
Graphical view of domain structure.
Gene3D G3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1; 1.
Pfam PF00155; Aminotran_1_2; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01821; 5aminolev_synth; 1.
PROSITE PS00599; AA_TRANSFER_CLASS_2; 1.
BLOCKS P08080.
ProtoNet P08080.
Genome annotation databases
GeneID 1234673; -.
GenomeReviews AL591688_GR; R02989.
KEGG sme:SMc03104; -.
NMPDR fig|266834.1.peg.4283; -.
Phylogenomic databases
HOGENOM P08080; -.
Genome annotation databases
CMR P08080; R02989.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acyltransferase; Complete proteome; Heme biosynthesis; Pyridoxal phosphate; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   404  404     5-aminolevulinate synthase. PRO_0000163827
BINDING   247   247        Pyridoxal phosphate (covalent) (By similarity). 
Sequence information
Length: 404 AA [This is the length of the unprocessed precursor] Molecular weight: 44116 Da [This is the MW of the unprocessed precursor] CRC64: 826BC15187083E07 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDFESFFKNE LDGLHQEGRY RVFADLARHR GSFPKATRYT ADGAQEVTVW CSNDYLGMGQ 

        70         80         90        100        110        120 
CPIVTEAMKN AIDECGAGAG GTRNISGTNH YHVLLERELA DLHGKESALL FTSGYVSNWA 

       130        140        150        160        170        180 
ALGTLCSKIP GVIVFSDAGN HASMIEGIRH SKCERVIFKH NSVADLEAKL AAADPRAPKI 

       190        200        210        220        230        240 
IAFESVYSMD GDIAPIREFC DLADKYGAMT YLDEVHAVGM YGPRGGGIAE REGLMHRLTV 

       250        260        270        280        290        300 
IEGTLGKAFG VMGGYITGSA ALCDFIRSFA SGFIFTTALP PALAAGALAS IRHLKESQVE 

       310        320        330        340        350        360 
RFAHQERVRR LRSLLDQRGI PHMVNPSHIV PVIVGDAAKC KWISDLLLDN FGIYVQPINY 

       370        380        390        400 
PTVPKKTERL RITPTPMHSD ADIDHLVSAL HSLWSRCALA RAVA 

P08080 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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NPSA logo NPSA Sequence analysis tools

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