NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=LMD 79.41;
PubMed=2536663 [NCBI, ExPASy, EBI, Israel, Japan]
Goosen N., Horsman H.P.A., Huinen R.G.M., van de Putte P.;
"Acinetobacter calcoaceticus genes involved in biosynthesis of the coenzyme pyrrolo-quinoline-quinone: nucleotide sequence and expression in Escherichia coli K-12.";
J. Bacteriol. 171:447-455(1989).

Comments

FUNCTION: Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ (By similarity).
CATALYTIC ACTIVITY: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O₂ = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H₂O₂ + 2 H₂O.
PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis .
SIMILARITY: Belongs to the pqqC family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X06452; CAA29754.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

D32252; D32252.

3D structure databases

ModBase

P07780.

Ontologies

GO:0033732;	Molecular function: pyrroloquinoline-quinone synthase activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0018189;	Biological process: pyrroloquinoline quinone biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00654; -; 1.
PBIL [Tree]

InterPro

IPR016084; Haem_Oase-like_multi-hlx.
IPR011845; PQQ_synth_PqqC.
IPR004305; TENA/THI4/PQQ_synth_PqqC.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.910.10; Haem_Oase-like_multi-hlx; 1.

Pfam

PF03070; TENA_THI-4; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02111; PQQ_syn_pqqC; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Oxidoreductase; PQQ biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 252`	`252`		`Pyrroloquinoline-quinone synthase.`	`PRO_0000219976`

Sequence information

Length: 252 AA [This is the length of the unprocessed precursor]

Molecular weight: 29706 Da [This is the MW of the unprocessed precursor]

CRC64: CCD97341C0C2B815 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTQTPEALTT EQFKQAIIDK GQYYHIYHPF HVMMYEGKAT QQQIQAWVAN RYYYQINIPL 

        70         80         90        100        110        120 
KDAAIMANCP DQRVRQEWIQ RMIDQDGEYP DGGGREAWLR LAEAVGLSRE QVISEELVLP 

       130        140        150        160        170        180 
GVRFAVDAYV NFRRRASWRE AASSSLTELF APQIHQSRLD SWPQHYPWID DKGYEYFRSR 

       190        200        210        220        230        240 
LSQARRDVEH GLTITLDSFT TFEQQERMLE ILQFKLDILW SILDALTLAY VHNEAPYHSV 

       250 
TSKRVWHKGL FK

P07780 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools