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UniProtKB/Swiss-Prot entry P07735

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GPDA_DROVI
Primary accession number P07735
Secondary accession number Q27634
Integrated into Swiss-Prot on August 1, 1988
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 4, 2008 (Entry version 71)
Name and origin of the protein
Protein name Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic
Synonyms GPDH-C
GPD-C
EC 1.1.1.8
Gene name
Name: Gpdh
From
Drosophila virilis (Fruit fly) [TaxID: 7244] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
Narise S., Tominaga H.;
"Temperature-dependency differencies in GPDH allozmyes associated with a single base change in the coding region of the GPDH structural gene in Drosophila virilis.";
Life Sci. Adv. (Genet.) 11:39-45(1992).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0167-4781(92)90086-F; PubMed=1610907 [NCBI, ExPASy, EBI, Israel, Japan]
Tominaga H., Shiba T., Narise S.;
"Structure of Drosophila virilis glycerol-3-phosphate dehydrogenase gene and a comparison with the Drosophila melanogaster gene.";
Biochim. Biophys. Acta 1131:233-238(1992).
[3]
 PROTEIN SEQUENCE OF 2-353.
Arai K., Tominaga H., Yokote Y., Narise S.;
"The complete amino-acid sequence of cytoplasmic glycerol-3-phosphate dehydrogenase from Drosophila virilis.";
Biochim. Biophys. Acta 953:6-13(1988).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X59076; CAA41800.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D10697; BAA01539.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A60985; A60985.
B60985; B60985.
JS0023; JS0023.
S31790; S31790.
3D structure databases
ModBase P07735.
Organism-specific databases
FlyBase FBgn0013081; Dvir\Gpdh.
Ontologies
GO
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013328; DHase_multihelical.
IPR016040; NAD(P)-bd.
IPR017751; NAD-dep_Gly3P_DH_euk.
IPR006168; NAD-dep_Gly3P_DHase.
IPR011128; NAD-dep_Gly3P_DHase_N.
IPR006109; NAD_Gly3P_DHase_C.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
PANTHER PTHR11728; NAD_Gly3P_DH; 1.
Pfam PF07479; NAD_Gly3P_dh_C; 1.
PF01210; NAD_Gly3P_dh_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000114; Glycerol-3-P_dh; 1.
PRINTS PR00077; GPDHDRGNASE.
ProDom PD001278; NAD_Gly3P_C; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00957; NAD_G3PDH; 1.
BLOCKS P07735.
ProtoNet P07735.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   353  352     Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic. PRO_0000138077
NP_BIND   11    16  6     NAD (By similarity). 
REGION   270   271  2     Substrate binding (By similarity). 
ACT_SITE   206   206        Proton acceptor (By similarity). 
BINDING   98    98        NAD (By similarity). 
BINDING   121   121        NAD; via amide nitrogen (By similarity). 
BINDING   121   121        Substrate (By similarity). 
BINDING   155   155        NAD; via amide nitrogen (By similarity). 
BINDING   270   270        NAD (By similarity). 
BINDING   299   299        NAD (By similarity). 
MOD_RES   2     2        Blocked amino end (Ala). 
CONFLICT   15    15        W -> N (in Ref. 3; AA sequence). 
CONFLICT   35    35        E -> K (in Ref. 1; CAA41800). 
Sequence information
Length: 353 AA [This is the length of the unprocessed precursor] Molecular weight: 38651 Da [This is the MW of the unprocessed precursor] CRC64: E18B4DF92303D8C2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAEKVNVCIV GSGNWGSAIA KIVGANAAAL PEFEERVTMF VYEEMIDGKK LTEIINETHE 

        70         80         90        100        110        120 
NVKYLKGHKL PTNVVAVPDL VEAAKNADIL IFVVPHQFIP NFCKQLLGKI KPNAIAISLI 

       130        140        150        160        170        180 
KGFDKAEGGG IDLISHIITR HLKIPCAVLM GANLANEVAE GNFCETTIGC TDKKYGKVLR 

       190        200        210        220        230        240 
DLFQANHFRV VVVEDADAVE VCGALKNIVA CGAGFVDGLK LGDNTKAAVI RLGLMEMIRF 

       250        260        270        280        290        300 
VDVFYPGSKL STFFESCGVA DLITTCYGGR NRRVSEAFVT SGKTIEDLEK EMLNGQKLQG 

       310        320        330        340        350 
PPTAEEVNYM LKNKGLEDKF PLFTAIHKIC TNQLKPKDLI DCIRNHPEHM QTL
P07735 in FASTA format

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