[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1016/0378-1119(85)90142-8; PubMed=3924741 [NCBI, ExPASy, EBI, Israel, Japan] Kenny E., Atkinson T., Hartley B.S.; "Nucleotide sequence of the thymidylate synthetase gene (thyP3) from the Bacillus subtilis phage phi 3T."; Gene 34:335-342(1985).

Comments

FUNCTION: Provides the sole de novo source of dTMP for DNA biosynthesis.
CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
PATHWAY: Pyrimidine metabolism; dTTP biosynthesis .
SUBUNIT: Homodimer.
SIMILARITY: Belongs to the thymidylate synthase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M10122; AAA32353.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A22800; SYBP3T.

3D structure databases

HSSP

P42326; 1BSP. [HSSP ENTRY / PDB]

SMR

P07606; 2-279.

ModBase

P07606.

Family and domain databases

InterPro

IPR000398; Thymidylat_synth_C.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.572.10; Thymidylat_synth_C; 1.

PANTHER

PTHR11549:SF2; Thymidylat_synth_C; 1.

Pfam

PF00303; Thymidylat_synt; 1.
Pfam graphical view of domain structure.

PRINTS

PR00108; THYMDSNTHASE.

ProDom

PD001180; Thymidylat_synth; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR03284; thym_sym; 1.

PROSITE

PS00091; THYMIDYLATE_SYNTHASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Methyltransferase; Nucleotide biosynthesis; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 279`	`279`	`Thymidylate synthase.`	`PRO_0000141060`
`ACT_SITE`	`161 161`		`By similarity.`

Sequence information

Length: 279 AA [This is the length of the unprocessed precursor]

Molecular weight: 32785 Da [This is the MW of the unprocessed precursor]

CRC64: F8FC67BD2DF7A727 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTQFDKQYNS IIKDIINNGI SDEEFDVRTK WDSDGTPAHT LSVMSKQMRF DNSEVPILTT 

        70         80         90        100        110        120 
KKVAWKTAIK ELLWIWQLKS NDVTELNKMG VHIWDQWKQE DGTIGHAYGF QLGKKNRSLN 

       130        140        150        160        170        180 
GEKVDQVDYL LHQLKNNPSS RRHITMLWNP DDLDAMALTP CVYETQWYVK QGKLHLEVRA 

       190        200        210        220        230        240 
RSNDMALGNP FNVFQYNVLQ RMIAQVTGYE LGEYIFNIGD CHVYTRHIDN LKIQMEREQF 

       250        260        270 
EAPELWINPE VKDFYNFTVD DFKLINYKHG DKLLFEVAV

P07606 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools