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UniProtKB/Swiss-Prot entry P07498


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CASK_HUMAN
Primary accession number P07498
Secondary accession number Q13575
Integrated into Swiss-Prot on April 1, 1988
Sequence was last modified on October 1, 1996 (Sequence version 3)
Annotations were last modified on    November 4, 2008 (Entry version 96)
Name and origin of the protein
Protein name Kappa-casein [Precursor]
Synonyms None
Gene name
Name: CSN3
Synonyms: CASK, CSN10, CSNK
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-145.
Menon R.S., Jeffers K.F., Chang Y.F., Ham R.G.;
Submitted (JUL-1991) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Mammary gland;
PubMed=1296818 [NCBI, ExPASy, EBI, Israel, Japan]
Bergstroem S., Hansson L., Hernell O., Loennerdal B., Nilsson A.K., Stroemqvist M.;
"Cloning and sequencing of human kappa-casein cDNA.";
DNA Seq. 3:245-246(1992).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANT LEU-110.
DOI=10.1016/0378-1119(96)00351-4; PubMed=8863730 [NCBI, ExPASy, EBI, Israel, Japan]
Edlund A., Johansson T., Leidvik B., Hansson L.;
"Structure of the human kappa-casein gene.";
Gene 174:65-69(1996).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT CYS-75.
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PROTEIN SEQUENCE OF 25-182.
DOI=10.1016/0014-5793(85)80872-3; PubMed=4018271 [NCBI, ExPASy, EBI, Israel, Japan]
Brignon G., Chtourou A., Ribadeau-Dumas B.;
"Preparation and amino acid sequence of human kappa-casein.";
FEBS Lett. 188:48-54(1985).
[6]
PROTEIN SEQUENCE OF 118-182, AND GLYCOSYLATION AT THR-133; THR-143; THR-148; THR-151; THR-157; THR-167 AND THR-169.
PubMed=7460900 [NCBI, ExPASy, EBI, Israel, Japan]
Fiat A.M., Jolles J., Aubert J.-P., Loucheux-Lefebvre M.H., Jolles P.;
"Localisation and importance of the sugar part of human casein.";
Eur. J. Biochem. 111:333-339(1980).
[7]
STRUCTURE BY NMR OF 108-125.
PubMed=10191473 [NCBI, ExPASy, EBI, Israel, Japan]
Plowman J.E., Creamer L.K., Liddell M.J., Cross J.J.;
"Structural features of a peptide corresponding to human kappa-casein residues 84-101 by 1H-nuclear magnetic resonance spectroscopy.";
J. Dairy Res. 66:53-63(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M73628; AAA59456.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X66417; CAA47048.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U51899; AAC50772.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC010935; AAH10935.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JC4957; KKHU.
RefSeq NP_005203.2; -.
UniGene Hs.54415
3D structure databases
ModBase P07498.
PTM databases
GlycoSuiteDB P07498; -.
PhosphoSite P07498; -.
Organism-specific databases
H-InvDB HIX0004262; -.
HGNC HGNC:2446; CSN3.
GenAtlas CSN3.
MIM 601695; gene. [NCBI / EBI]
PharmGKB PA26949; -.
GeneCards P07498.
Gene expression databases
ArrayExpress P07498; -.
CleanEx HS_CASK; -.
HS_CSN3; -.
GermOnline ENSG00000171209; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR000117; Casein_kappa.
Graphical view of domain structure.
PANTHER PTHR11470; Casein_kappa; 1.
Pfam PF00997; Casein_kappa; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF002374; Casein_kappa; 1.
ProDom PD003689; Casein_kappa; 1.
[Domain structure / List of seq. sharing at least 1 domain]
BLOCKS P07498.
ProtoNet P07498.
Genome annotation databases
Ensembl ENSG00000171209; Homo sapiens. [Contig view]
GeneID 1448; -.
KEGG hsa:1448; -.
Phylogenomic databases
HOGENOM P07498; -.
HOVERGEN P07498; -.
Other
NextBio 5951; -.
SOURCE CSN3; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Glycoprotein; Milk protein; Phosphoprotein; Polymorphism; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    20  20      
CHAIN   21   182  162     Kappa-casein. PRO_0000004498
SITE   117   118  2     Cleavage; by chymosin/rennin. 
CARBOHYD   133   133        O-linked (GalNAc...). 
CARBOHYD   143   143        O-linked (GalNAc...). 
CARBOHYD   148   148        O-linked (GalNAc...). 
CARBOHYD   151   151        O-linked (GalNAc...). 
CARBOHYD   157   157        O-linked (GalNAc...). 
CARBOHYD   167   167        O-linked (GalNAc...). 
CARBOHYD   169   169        O-linked (GalNAc...). 
VARIANT   75    75  1     Y -> C (in dbSNP:rs17850702 [NCBI]). VAR_026338 
VARIANT   110   110  1     R -> L (in dbSNP:rs1048152 [NCBI]). VAR_026339 
VARIANT   145   145  1     A -> T (in dbSNP:rs3775739 [NCBI]). VAR_026340 
CONFLICT   25    27        QKQ -> EQK (in Ref. 5; AA sequence). 
CONFLICT   153   153        D -> N (in Ref. 5; AA sequence). 
CONFLICT   162   162        S -> T (in Ref. 5 and 6). 
CONFLICT   173   173        T -> P (in Ref. 5 and 6). 
CONFLICT   178   181        TPPT -> PTTS (in Ref. 5 and 6). 
Sequence information
Length: 182 AA [This is the length of the unprocessed precursor] Molecular weight: 20305 Da [This is the MW of the unprocessed precursor] CRC64: 8A1609D2D5C94895 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKSFLLVVNA LALTLPFLAV EVQNQKQPAC HENDERPFYQ KTAPYVPMYY VPNSYPYYGT 

        70         80         90        100        110        120 
NLYQRRPAIA INNPYVPRTY YANPAVVRPH AQIPQRQYLP NSHPPTVVRR PNLHPSFIAI 

       130        140        150        160        170        180 
PPKKIQDKII IPTINTIATV EPTPAPATEP TVDSVVTPEA FSESIITSTP ETTTVAVTPP 


TA 

P07498 in FASTA format

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