ID CAH3_HUMAN Reviewed; 260 AA. AC P07451; B2R867; O60842; DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot. DT 20-MAR-2007, sequence version 3. DT 16-DEC-2008, entry version 104. DE RecName: Full=Carbonic anhydrase 3; DE EC=4.2.1.1; DE AltName: Full=Carbonic anhydrase III; DE Short=CA-III; DE AltName: Full=Carbonate dehydratase III; GN Name=CA3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=86221704; PubMed=3086182; DOI=10.1016/0378-1119(86)90103-4; RA Lloyd J., McMillan S., Hopkinson D., Edwards Y.H.; RT "Nucleotide sequence and derived amino acid sequence of a cDNA RT encoding human muscle carbonic anhydrase."; RL Gene 41:233-239(1986). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=87092290; PubMed=3099285; RA Wade R., Gunning P., Eddy R., Shows T., Kedes L.; RT "Nucleotide sequence, tissue-specific expression, and chromosome RT location of human carbonic anhydrase III: the human CAIII gene is RT located on the same chromosome as the closely linked CAI and CAII RT genes."; RL Proc. Natl. Acad. Sci. U.S.A. 83:9571-9575(1986). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Pericardium; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-31. RC TISSUE=Muscle; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=88056301; PubMed=2824285; RA Lloyd J., Brownson C., Tweedie S., Charlton J., Edwards Y.H.; RT "Human muscle carbonic anhydrase: gene structure and DNA methylation RT patterns in fetal and adult tissues."; RL Genes Dev. 1:594-602(1987). RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11, AND DEVELOPMENTAL STAGE. RX MEDLINE=98322264; PubMed=9651514; DOI=10.1016/S0378-1119(98)00201-7; RA Sowden J., Smith H., Morrison K., Edwards Y.; RT "Sequence comparisons and functional studies of the proximal promoter RT of the carbonic anhydrase 3 (CA3) gene."; RL Gene 214:157-165(1998). CC -!- FUNCTION: Reversible hydration of carbon dioxide. CC -!- CATALYTIC ACTIVITY: H(2)CO(3) = CO(2) + H(2)O. CC -!- COFACTOR: Zinc (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- TISSUE SPECIFICITY: Muscle specific. CC -!- DEVELOPMENTAL STAGE: At 6 weeks gestation, transcripts accumulate CC at low levels in the somites and at high levels throughout the CC notochord. As gestation continues, CA3 becomes abundant in all CC developing muscle masses and continues at high to moderate levels CC in the notochord. CC -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; M29458; AAA52293.1; -; Genomic_DNA. DR EMBL; M29452; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AK313254; BAG36064.1; -; mRNA. DR EMBL; BC004897; AAH04897.1; -; mRNA. DR EMBL; AJ006473; CAA07056.1; -; Genomic_DNA. DR PIR; A26658; CRHU3. DR RefSeq; NP_005172.1; -. DR UniGene; Hs.82129; -. DR PDB; 1Z93; X-ray; 2.10 A; A=1-260. DR PDB; 1Z97; X-ray; 2.10 A; A=1-260. DR PDB; 2HFW; X-ray; 2.50 A; A=1-260. DR PDB; 2HFX; X-ray; 1.70 A; A=1-260. DR PDB; 2HFY; X-ray; 2.60 A; A=1-260. DR PDBsum; 1Z93; -. DR PDBsum; 1Z97; -. DR PDBsum; 2HFW; -. DR PDBsum; 2HFX; -. DR PDBsum; 2HFY; -. DR PhosphoSite; P07451; -. DR HSC-2DPAGE; P07451; -. DR Ensembl; ENSG00000164879; Homo sapiens. DR GeneID; 761; -. DR KEGG; hsa:761; -. DR GeneCards; GC08P086537; -. DR H-InvDB; HIX0078885; -. DR HGNC; HGNC:1374; CA3. DR HPA; CAB004967; -. DR MIM; 114750; gene. DR PharmGKB; PA24378; -. DR HOGENOM; P07451; -. DR HOVERGEN; P07451; -. DR NextBio; 3078; -. DR ArrayExpress; P07451; -. DR CleanEx; HS_CA3; -. DR GermOnline; ENSG00000164879; Homo sapiens. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0004089; F:carbonate dehydratase activity; TAS:ProtInc. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0006730; P:one-carbon compound metabolic process; IEA:InterPro. DR InterPro; IPR001148; Euk_COanhd. DR Gene3D; G3DSA:3.10.200.10; Euk_COanhd; 1. DR PANTHER; PTHR18952; Euk_COanhd; 1. DR Pfam; PF00194; Carb_anhydrase; 1. DR ProDom; PD000865; Euk_COanhd; 1. DR PROSITE; PS00162; ALPHA_CA_1; 1. DR PROSITE; PS51144; ALPHA_CA_2; 1. PE 1: Evidence at protein level; KW 3D-structure; Cytoplasm; Lyase; Metal-binding; Polymorphism; Zinc. FT INIT_MET 1 1 Removed (By similarity). FT CHAIN 2 260 Carbonic anhydrase 3. FT /FTId=PRO_0000077426. FT METAL 94 94 Zinc; catalytic. FT METAL 96 96 Zinc; catalytic. FT METAL 119 119 Zinc; catalytic. FT VARIANT 31 31 V -> I (in dbSNP:rs20571). FT /FTId=VAR_016180. FT STRAND 7 12 FT HELIX 13 16 FT TURN 17 19 FT HELIX 21 24 FT HELIX 35 37 FT STRAND 47 50 FT HELIX 53 55 FT STRAND 56 61 FT STRAND 66 70 FT STRAND 73 81 FT STRAND 88 97 FT STRAND 106 109 FT STRAND 115 123 FT HELIX 125 127 FT HELIX 130 133 FT STRAND 139 151 FT HELIX 154 162 FT HELIX 163 166 FT STRAND 171 174 FT HELIX 180 183 FT STRAND 190 195 FT STRAND 206 213 FT STRAND 215 217 FT HELIX 219 225 FT STRAND 229 231 FT STRAND 233 235 FT STRAND 256 259 SQ SEQUENCE 260 AA; 29557 MW; A305334167233FCF CRC64; MAKEWGYASH NGPDHWHELF PNAKGENQSP VELHTKDIRH DPSLQPWSVS YDGGSAKTIL NNGKTCRVVF DDTYDRSMLR GGPLPGPYRL RQFHLHWGSS DDHGSEHTVD GVKYAAELHL VHWNPKYNTF KEALKQRDGI AVIGIFLKIG HENGEFQIFL DALDKIKTKG KEAPFTKFDP SCLFPACRDY WTYQGSFTTP PCEECIVWLL LKEPMTVSSD QMAKLRSLLS SAENEPPVPL VSNWRPPQPI NNRVVRASFK //