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UniProtKB/Swiss-Prot entry P07338

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CTRB1_RAT
Primary accession number P07338
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1988
Sequence was last modified on April 1, 1988 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 77)
Name and origin of the protein
Protein name Chymotrypsinogen B [Precursor]
Synonym EC 3.4.21.1
Contains Chymotrypsin B chain A
Chymotrypsin B chain B
Chymotrypsin B chain C
Gene name
Name: Ctrb1
Synonyms: Ctrb
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=6209274 [NCBI, ExPASy, EBI, Israel, Japan]
Bell G.I., Quinto C., Quiroga M., Valenzuela P., Craik C.S., Rutter W.J.;
"Isolation and sequence of a rat chymotrypsin B gene.";
J. Biol. Chem. 259:14265-14270(1984).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
K02298; AAA98732.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A22658; KYRTB.
RefSeq NP_036668.1; -.
UniGene Rn.105845
3D structure databases
PDB
1KDQ; X-ray; 2.55 A; A=34-164, B=165-263.[ExPASy / RCSB / EBI]
2JET; X-ray; 2.20 A; B=37-164, C=165-263.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1KDQ; -.
2JET; -.
SMR P07338; 19-263.
ModBase P07338.
Protein family/group databases
MEROPS S01.152; -.
Organism-specific databases
RGD 2444; Ctrb1.
Gene expression databases
ArrayExpress P07338; -.
GermOnline ENSRNOG00000019068; Rattus norvegicus.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0007586; Biological process: digestion (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001254; Peptidase_S1_S6.
IPR001314; Peptidase_S1A.
Graphical view of domain structure.
Pfam PF00089; Trypsin; 1.
Pfam graphical view of domain structure.
PRINTS PR00722; CHYMOTRYPSIN.
SMART SM00020; Tryp_SPc; 1.
SMART graphical view of domain structure.
PROSITE PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; 1.
PS00135; TRYPSIN_SER; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P07338.
ProtoNet P07338.
Genome annotation databases
Ensembl ENSRNOG00000019068; Rattus norvegicus. [Contig view]
GeneID 24291; -.
KEGG rno:24291; -.
Phylogenomic databases
HOVERGEN P07338; -.
Other
NextBio 602890; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Digestion; Hydrolase; Protease; Secreted; Serine protease; Signal; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    18  18      
CHAIN   19   263  245     Chymotrypsinogen B. PRO_0000027642
CHAIN   19    31  13     Chymotrypsin B chain A. PRO_0000027643
CHAIN   34   164  131     Chymotrypsin B chain B. PRO_0000027644
CHAIN   167   263  97     Chymotrypsin B chain C. PRO_0000027645
DOMAIN   34   261  228     Peptidase S1. 
ACT_SITE   75    75        Charge relay system (By similarity). 
ACT_SITE   120   120        Charge relay system (By similarity). 
ACT_SITE   213   213        Charge relay system (By similarity). 
DISULFID   19   140        By similarity. 
DISULFID   60    76         
DISULFID   154   219         
DISULFID   186   200        By similarity. 
DISULFID   209   238        By similarity. 
STRAND   48    52  5      
STRAND   58    72  15      
STRAND   83    87  5      
STRAND   99   108  10      
TURN   114   116  3      
STRAND   122   128  7      
STRAND   133   135  3      
STRAND   153   158  6      
STRAND   174   181  8      
HELIX   183   189  7      
STRAND   198   201  4      
STRAND   204   207  4      
HELIX   208   210  3      
STRAND   216   234  19      
STRAND   244   248  5      
HELIX   249   260  12      
Sequence information
Length: 263 AA [This is the length of the unprocessed precursor] Molecular weight: 27849 Da [This is the MW of the unprocessed precursor] CRC64: ACAFDBACF8C4DA6D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAFLWLVSCF ALVGATFGCG VPTIQPVLTG LSRIVNGEDA IPGSWPWQVS LQDKTGFHFC 

        70         80         90        100        110        120 
GGSLISEDWV VTAAHCGVKT SDVVVAGEFD QGSDEENIQV LKIAQVFKNP KFNMFTVRND 

       130        140        150        160        170        180 
ITLLKLATPA QFSETVSAVC LPNVDDDFPP GTVCATTGWG KTKYNALKTP EKLQQAALPI 

       190        200        210        220        230        240 
VSEADCKKSW GSKITDVMTC AGASGVSSCM GDSGGPLVCQ KDGVWTLAGI VSWGSGVCST 

       250        260 
STPAVYSRVT ALMPWVQQIL EAN
P07338 in FASTA format

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