[1]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/0378-1119(85)90321-X; PubMed=3005113 [NCBI, ExPASy, EBI, Israel, Japan]
Benfield P.A.,
Henderson L.,
Pearson M.L.;
"Expression of a rat brain creatine kinase-beta-galactosidase fusion protein in Escherichia coli and derivation of the complete amino acid sequence of rat brain creatine kinase.";
Gene 39:263-267(1985).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(88)90527-6; PubMed=2838389 [NCBI, ExPASy, EBI, Israel, Japan]
Benfield P.A.,
Graf D.,
Korolkoff P.N.,
Hobson G.,
Pearson M.L.;
"Isolation of four rat creatine kinase genes and identification of multiple potential promoter sequences within the rat brain creatine kinase promoter region.";
Gene 63:227-243(1988).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
TISSUE=Uterus;
PubMed=2284002 [NCBI, ExPASy, EBI, Israel, Japan]
Pentecost B.T.,
Mattheiss L.,
Dickerman H.W.,
Kumar S.A.;
"Estrogen regulation of creatine kinase-B in the rat uterus.";
Mol. Endocrinol. 4:1000-1010(1990).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, Embryonic brain, Heart, and Prostate;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[5]
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PROTEIN SEQUENCE OF 33-43; 87-96; 108-130; 138-148; 157-172; 224-236; 253-265 AND 320-341, AND MASS SPECTROMETRY.
STRAIN=Sprague-Dawley;
TISSUE=Hippocampus, and Spinal cord;
Lubec G.,
Afjehi-Sadat L.,
Diao W.,
Chen W.-Q.;
Submitted (APR-2007) to UniProtKB.
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[6]
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PHOSPHORYLATION.
PubMed=6477506 [NCBI, ExPASy, EBI, Israel, Japan]
Mahadevan L.C.,
Whatley S.A.,
Leung T.K.C.,
Lim L.;
"The brain isoform of a key ATP-regulating enzyme, creatine kinase, is a phosphoprotein.";
Biochem. J. 222:139-144(1984).
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[7]
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TISSUE SPECIFICITY.
PubMed=1939264 [NCBI, ExPASy, EBI, Israel, Japan]
Friedman D.L.,
Perryman M.B.;
"Compartmentation of multiple forms of creatine kinase in the distal nephron of the rat kidney.";
J. Biol. Chem. 266:22404-22410(1991).
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- FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
- CATALYTIC ACTIVITY: ATP + creatine = ADP + phosphocreatine.
- SUBUNIT: Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.
- SUBCELLULAR LOCATION: Cytoplasm.
- TISSUE SPECIFICITY: In the kidney localized primarily in the outer medulla in the thick ascending limb and distal convoluted tubule.
- SIMILARITY: Belongs to the ATP:guanido phosphotransferase family.
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