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UniProtKB/Swiss-Prot entry P07332


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FES_HUMAN
Primary accession number P07332
Secondary accession number Q6GTU5
Integrated into Swiss-Prot on April 1, 1988
Sequence was last modified on October 3, 2006 (Sequence version 3)
Annotations were last modified on    November 4, 2008 (Entry version 101)
Name and origin of the protein
Protein name Proto-oncogene tyrosine-protein kinase Fes/Fps
Synonyms C-Fes
EC 2.7.10.2
Gene name
Name: FES
Synonyms: FPS
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2179816 [NCBI, ExPASy, EBI, Israel, Japan]
Alcalay M., Antolini F., van de Ven W.J.M., Lanfrancone L., Grignani F., Pelicci P.G.;
"Characterization of human and mouse c-fes cDNA clones and identification of the 5' end of the gene.";
Oncogene 5:267-275(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=4065096 [NCBI, ExPASy, EBI, Israel, Japan]
Roebroek A.J.M., Schalken J.A., Verbeek J.S., van den Ouweland A.M.W., Onnekink C., Bloemers H.P.J., van de Ven W.J.M.;
"The structure of the human c-fes/fps proto-oncogene.";
EMBO J. 4:2897-2903(1985).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
STRUCTURE BY NMR OF 450-550.
DOI=10.1007/s10858-005-0946-6; PubMed=15929003 [NCBI, ExPASy, EBI, Israel, Japan]
Scott A., Pantoja-Uceda D., Koshiba S., Inoue M., Kigawa T., Terada T., Shirouzu M., Tanaka A., Sugano S., Yokoyama S., Guentert P.;
"Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes.";
J. Biomol. NMR 31:357-361(2005).
[5]
VARIANTS [LARGE SCALE ANALYSIS] CYS-85; GLN-246 AND VAL-323.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X52192; CAA36438.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X06292; CAA29619.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC035357; AAH35357.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A24673; TVHUFF.
RefSeq NP_001996.1; -.
UniGene Hs.7636
3D structure databases
PDB
1WQU; NMR; -; A=450-550.[ExPASy / RCSB / EBI]
2DCR; NMR; -; A=450-550.[ExPASy / RCSB / EBI]
3BKB; X-ray; 1.78 A; A=446-822.[ExPASy / RCSB / EBI]
3CBL; X-ray; 1.75 A; A=446-822.[ExPASy / RCSB / EBI]
3CD3; X-ray; 1.98 A; A=446-822.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1WQU; -.
2DCR; -.
3BKB; -.
3CBL; -.
3CD3; -.
ModBase P07332.
PTM databases
PhosphoSite P07332; -.
Organism-specific databases
H-InvDB HIX0026902; -.
HGNC HGNC:3657; FES.
GenAtlas FES.
HPA HPA001376; -.
MIM 190030; gene. [NCBI / EBI]
PharmGKB PA28098; -.
GeneCards P07332.
Gene expression databases
ArrayExpress P07332; -.
CleanEx HS_FES; -.
GermOnline ENSG00000182511; Homo sapiens.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from direct assay from HPA).
GO:0004713; Molecular function: protein tyrosine kinase activity (traceable author statement from ProtInc).
GO:0008283; Biological process: cell proliferation (traceable author statement from ProtInc).
GO:0007275; Biological process: multicellular organismal development (traceable author statement from ProtInc).
GO:0006468; Biological process: protein amino acid phosphorylation (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR001060; Cdc15_Fes_CIP4.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR000980; SH2.
IPR001245; Tyr_pkinase.
IPR008266; Tyr_pkinase_AS.
IPR016250; TyrPK_fps.
Graphical view of domain structure.
Gene3D G3DSA:3.30.505.10; SH2; 1.
Pfam PF00611; FCH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000632; TyrPK_fps; 1.
PRINTS PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
ProDom PD000001; Prot_kinase; 1.
PD000093; SH2; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00055; FCH; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 1.
SMART graphical view of domain structure.
PROSITE PS50133; FCH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P07332.
ProtoNet P07332.
Genome annotation databases
Ensembl ENSG00000182511; Homo sapiens. [Contig view]
GeneID 2242; -.
KEGG hsa:2242; -.
Phylogenomic databases
HOGENOM P07332; -.
HOVERGEN P07332; -.
Other
NextBio 9069; -.
SOURCE FES; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Proto-oncogene; SH2 domain; Transferase; Tyrosine-protein kinase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   822  822     Proto-oncogene tyrosine-protein kinase Fes/Fps. PRO_0000088088
DOMAIN   1    69  69     FCH. 
DOMAIN   460   549  90     SH2. 
DOMAIN   561   822  262     Protein kinase. 
NP_BIND   567   575  9     ATP (By similarity). 
ACT_SITE   683   683        Proton acceptor (By similarity). 
BINDING   590   590        ATP (By similarity). 
MOD_RES   713   713        Phosphotyrosine; by autocatalysis (By similarity). 
VARIANT   85    85  1     R -> C. VAR_041697 
VARIANT   246   246  1     R -> Q. VAR_041698 
VARIANT   323   323  1     M -> V. VAR_041699 
CONFLICT   719   719        L -> S (in Ref. 1; CAA36438). 
HELIX   450   452  3      
HELIX   455   457  3      
HELIX   467   473  7      
STRAND   479   485  7      
TURN   486   489  4      
STRAND   490   497  8      
STRAND   500   505  6      
STRAND   507   509  3      
STRAND   512   517  6      
STRAND   520   522  3      
HELIX   523   533  11      
TURN   539   541  3      
HELIX   558   560  3      
STRAND   561   569  9      
STRAND   571   580  10      
TURN   581   583  3      
STRAND   586   590  5      
HELIX   598   601  4      
HELIX   602   605  4      
HELIX   606   611  6      
STRAND   622   626  5      
STRAND   628   631  4      
STRAND   633   637  5      
HELIX   644   651  8      
HELIX   652   654  3      
HELIX   657   676  20      
HELIX   686   688  3      
STRAND   689   691  3      
STRAND   697   699  3      
STRAND   711   714  4      
HELIX   724   726  3      
HELIX   729   734  6      
STRAND   736   738  3      
HELIX   739   754  16      
HELIX   766   774  9      
HELIX   787   796  10      
HELIX   801   803  3      
HELIX   807   819  13      
Sequence information
Length: 822 AA [This is the length of the unprocessed precursor] Molecular weight: 93497 Da [This is the MW of the unprocessed precursor] CRC64: 4C2A90555857F045 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGFSSELCSP QGHGVLQQMQ EAELRLLEGM RKWMAQRVKS DREYAGLLHH MSLQDSGGQS 

        70         80         90        100        110        120 
RAISPDSPIS QSWAEITSQT EGLSRLLRQH AEDLNSGPLS KLSLLIRERQ QLRKTYSEQW 

       130        140        150        160        170        180 
QQLQQELTKT HSQDIEKLKS QYRALARDSA QAKRKYQEAS KDKDRDKAKD KYVRSLWKLF 

       190        200        210        220        230        240 
AHHNRYVLGV RAAQLHHQHH HQLLLPGLLR SLQDLHEEMA CILKEILQEY LEISSLVQDE 

       250        260        270        280        290        300 
VVAIHREMAA AAARIQPEAE YQGFLRQYGS APDVPPCVTF DESLLEEGEP LEPGELQLNE 

       310        320        330        340        350        360 
LTVESVQHTL TSVTDELAVA TEMVFRRQEM VTQLQQELRN EEENTHPRER VQLLGKRQVL 

       370        380        390        400        410        420 
QEALQGLQVA LCSQAKLQAQ QELLQTKLEH LGPGEPPPVL LLQDDRHSTS SSEQEREGGR 

       430        440        450        460        470        480 
TPTLEILKSH ISGIFRPKFS LPPPLQLIPE VQKPLHEQLW YHGAIPRAEV AELLVHSGDF 

       490        500        510        520        530        540 
LVRESQGKQE YVLSVLWDGL PRHFIIQSLD NLYRLEGEGF PSIPLLIDHL LSTQQPLTKK 

       550        560        570        580        590        600 
SGVVLHRAVP KDKWVLNHED LVLGEQIGRG NFGEVFSGRL RADNTLVAVK SCRETLPPDL 

       610        620        630        640        650        660 
KAKFLQEARI LKQYSHPNIV RLIGVCTQKQ PIYIVMELVQ GGDFLTFLRT EGARLRVKTL 

       670        680        690        700        710        720 
LQMVGDAAAG MEYLESKCCI HRDLAARNCL VTEKNVLKIS DFGMSREEAD GVYAASGGLR 

       730        740        750        760        770        780 
QVPVKWTAPE ALNYGRYSSE SDVWSFGILL WETFSLGASP YPNLSNQQTR EFVEKGGRLP 

       790        800        810        820 
CPELCPDAVF RLMEQCWAYE PGQRPSFSTI YQELQSIRKR HR 

P07332 in FASTA format

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View entry in raw text format (no links)
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